Neuronal histamine and H1 receptors regulate biological rhythm and energy metabolism

• Project/Area Number: 19591082
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Oita University
• Principal Investigator: YOSHIMATSU Hironobu Oita University, 医学部, 教授 (00166993)
• Co-Investigator(Kenkyū-buntansha): KAKUMA Tetsuya 大分大学, 医学部, 助教 (80343359)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 内分泌学 / 神経ヒスタミン / H1受容体 / エストロゲン / オレキシン / 肥満 / リズム / 前頭 / 視交叉上核 / エネルギー代謝 / 時計遺伝子 / BMAL-1

Research Abstract

メタボリックシンドロームや肥満症の発症メカニズムと治療法を明らかにするために、神経ヒスタミンH1受容体を介する生体リズム調節とエネルギー代謝調節のクロストーク機構を解析した。その結果、神経ヒスタミンおよびH1受容体はオレキシンやエストロゲンなど他の神経性・液性情報によって駆動され、生物時計が存在する視交叉上核への神経連絡あるいは前頭前野機能などと連動することで食行動や情動行動のリズム調節に関与していることが明らかになった。

Research Products

• [Journal Article] Adrenomedullin Improves cardiac expression of heat-shock protein 72 and tolerance against Ischemia/reperfusion injury in insulin-resistant rats (2009)
  • Author(s): Torigoe Y, Takahashi N, Hara M, Yoshimatsu H, Saikawa T.
  • Journal Title: Endocrinology 150 Pages: 1450-5
  • Peer Reviewed
• [Journal Article] Acute central administration of immepip, a histamine H3 receptor agonist, suppresses hypothalamic histamine release and elicits feeding behavior in rats (2009)
  • Author(s): Chiba S, Itateyama E, Sakata T, Yoshimatsu H.
  • Journal Title: Brain Res Bull 79 Pages: 37-40
  • Peer Reviewed
• [Journal Article] Adrenomedullin improves cardiac expression of heat-shoek protein 72 and tolerance against ischemia/reperfusion injury in insulin-resistant rats. (2009)
  • Author(s): Torigoe Y, et al
  • Journal Title: Endocrinology 150 Pages: 1450-5
  • Peer Reviewed
• [Journal Article] Acute central administration of immepip, a histamine H3 receptor agonist, suppresses hypothalamic histamine release and elicits feeding behavior in rats. (2009)
  • Author(s): Chiba S, et al
  • Journal Title: Brain Res Bull 79 Pages: 37-40
  • Peer Reviewed
• [Journal Article] Hypothalamic neuronal histamine regulates body weight through the modulation of diurnal feeding rhythm (2008)
  • Author(s): Yoshimatsu H
  • Journal Title: Nutrition 24 Pages: 827-31
  • Peer Reviewed
• [Journal Article] Effects of Pravastatin on Obesity, Diabetes, and Adiponectin in Diet-induced Obese Mice (2008)
  • Author(s): Araki K, Masaki T, Katsuragi I, Kakuma T, Yoshimatsu H.
  • Journal Title: Obesity (Silver Spring)
  • Peer Reviewed
• [Journal Article] FUNCTIONAL POTENTIATION OF LEPTIN-STAT3 SIGNALING BY THE ANDROGEN RECEPTOR (2008)
  • Author(s): Fan W, Yanase T, Nishi Y, Chiba S, Okabe T, Nomura M, Yoshimatsu H, Kato S, Takayanagi R, Nawata H.
  • Journal Title: Endocrinology
  • Peer Reviewed
• [Journal Article] Retinol binding prote in 4 concentrations are influenced by renal function in patients with type 2 diabetes mellitus. (2008)
  • Author(s): Masaki T, et al
  • Journal Title: Metabolism 57 Pages: 1340-4
  • Peer Reviewed
• [Journal Article] Hypothalamic neuronal histamine regulates body weight through the modulation of diurnal feeding rhythm. (2008)
  • Author(s): Yoshimatsu H
  • Journal Title: Nutrition 24 Pages: 827-31
  • Peer Reviewed
• [Journal Article] Effects of Pravastatin on Obesity, Diabetes, and Adiponectin in Diet-induced Obese Mice. (2008)
  • Author(s): Araki K, et al
  • Journal Title: Obesity (Silver Spring) 16 Pages: 2068-73
  • Peer Reviewed
• [Journal Article] Functional potentiation of leptin-signal transducer and activator of transcription 3 signaling by the androgen receptor. (2008)
  • Author(s): Fan W, et al
  • Journal Title: Endocrinology 149 Pages: 6028-36
  • Peer Reviewed
• [Journal Article] Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake (2007)
  • Author(s): Gotoh K, Fukagawa K, Fukagawa T, Noguchi H, Kakuma T, Sakata T, Yoshimatsu H.
  • Journal Title: J Neurochem 103 Pages: 1102-10
  • Peer Reviewed
• [Journal Article] TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c) (2007)
  • Author(s): Endo M, Masaki T, Seike M, Yoshimatsu H.
  • Journal Title: Exp Biol Med (Maywood) 232 Pages: 614-21
  • Peer Reviewed
• [Journal Article] Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice (2007)
  • Author(s): Higuchi K, Masaki T, Gotoh K, Chiba S, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H.
  • Journal Title: Endocrinology 148 Pages: 2690-7
  • Peer Reviewed
• [Journal Article] Involvement of stomach ghrelin and hypothalamic neuropeptides in tumor necrosis factor-alpha-induced hypophagia in mice (2007)
  • Author(s): Endo M, Masaki T, Seike M, Yoshimatsu H.
  • Journal Title: Regul Pept. 140 Pages: 94-100
  • Peer Reviewed
• [Journal Article] Therapeutic approach of histamine H3 receptors in obesity. (2007)
  • Author(s): Masaki T, et. al.
  • Journal Title: Recent Patents CNS Drug Discov 2 Pages: 238-40
  • Peer Reviewed
• [Journal Article] Neuronal histamine and its receptors in obesity and diabetes. (2007)
  • Author(s): Masaki T, et. al.
  • Journal Title: Curr Diabetes Rev 3 Pages: 212-6
  • Peer Reviewed
• [Journal Article] Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake. (2007)
  • Author(s): Gotoh K, et. al.
  • Journal Title: J Neurochem. 103 Pages: 1102-10
  • Peer Reviewed
• [Journal Article] Neuronal histamine and histamine receptors in food intake and obesity. (2007)
  • Author(s): Masaki T, et. al.
  • Journal Title: Mini Rev Med Chem 7 Pages: 821-5
  • Peer Reviewed
• [Journal Article] TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-lc (SREBP-lc). (2007)
  • Author(s): Endo M, et. al.
  • Journal Title: Exp Biol Med (Maywood) 232 Pages: 614-21
  • Peer Reviewed
• [Journal Article] Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice. (2007)
  • Author(s): Higuchi K, et. al.
  • Journal Title: Endocrinology 148 Pages: 2690-7
  • Peer Reviewed
• [Journal Article] Hyperhomocysteinemia is associated with visceral adiposity in Japanese patients with type 2 diabetes mellitus. (2007)
  • Author(s): Masaki T, et. al.
  • Journal Title: Diabetes Res Clin Pract 77 Pages: 168-73
  • Peer Reviewed
• [Journal Article] Involvement of stomach ghrelin and hypothalamic neuropeptides in tumornecrosis factor-alpha-induced hypophagia in mice. (2007)
  • Author(s): Endo M, et. al.
  • Journal Title: Regul Pept 5 Pages: 94-100
  • Peer Reviewed
• [Presentation] 中枢神経系からアプローチする新たな肥満症治療ターゲット神経ヒスタミンによる視床下部機能のクロストーク (2008)
  • Author(s): 吉松博信
  • Organizer: 第29回日本肥満学会
  • Place of Presentation: 大分
  • Year and Date: 2008-10-17
• [Presentation] 中枢神経系からアプローチする新たな肥満症治療ターゲット 神経ヒスタミンによる視床下部機能のクロストーク (2008)
  • Author(s): 吉松 博信
  • Organizer: 第29回日本肥満学会
  • Place of Presentation: 大分
  • Year and Date: 2008-10-17
• [Presentation] 肥満症治療の新たなアプローチ (2008)
  • Author(s): 吉松 博信
  • Organizer: 第31回日本高血圧学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-11
• [Presentation] 摂食障害における脳内ストレス情報処理と神経ヒスタミン (2008)
  • Author(s): 吉松博信
  • Organizer: 第4回日本摂食障害学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-20
• [Presentation] 肥満症の新たな治療戦略 (2008)
  • Author(s): 吉松 博信
  • Organizer: 第63回日本体力医学会大会
  • Place of Presentation: 大分
  • Year and Date: 2008-09-19
• [Presentation] 抗肥満薬の最新の動向 (2008)
  • Author(s): 吉松 博信
  • Organizer: 第1回日本肥満症治療学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-15
• [Presentation] 肥満症治療の新たな展開 (2008)
  • Author(s): 吉松 博信
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森
  • Year and Date: 2008-05-16
• [Presentation] 肥満症の正しい理解と治療 (2007)
  • Author(s): 吉松 博信
  • Organizer: 第45回全国大学保健管理研究集会
  • Place of Presentation: 大分
  • Year and Date: 2007-10-11
• [Presentation] メタボリックシンドロームの病態と治療 (2007)
  • Author(s): 吉松 博信
  • Organizer: 第43回日本赤十字社医学会総会
  • Place of Presentation: 大分
  • Year and Date: 2007-10-11
• [Presentation] 肥満症治療の展望 (2007)
  • Author(s): 吉松 博信
  • Organizer: 第57回日本体質医学会総会
  • Place of Presentation: 大分
  • Year and Date: 2007-09-29
• [Presentation] 肥満症の新たな治療戦略 (2007)
  • Author(s): 吉松 博信
  • Organizer: 第50回日本糖尿病学会年次学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-26
• [Book] キーワードでわかる! メタボリックシンドローム (2008)
  • Author(s): 正木 孝幸 吉松 博信
  • Publisher: 中外医学社
• [Book] キーワードでわかる! メタボリツクシンドローム (2008)
  • Author(s): 吉松 博信
  • Publisher: 中外医学社
• [Book] NASH診療best approach (2008)
  • Author(s): 清家 正隆 吉松 博信
  • Publisher: 中外医学社
• [Book] カラー版糖尿病学基礎と臨床 (2007)
  • Author(s): 吉松博信
  • Publisher: 西村書店
• [Book] 内科学第9版 (2007)
  • Author(s): 吉松博信
  • Publisher: 朝倉書店
• [Book] 現場での疑問に答える 糖尿病診療Q&A 寺内康夫 編 (2007)
  • Author(s): 吉松 博信
  • Publisher: 中外医学社
• [Book] 現場での疑問に答える 糖尿病療養指導Q&A 寺内康夫 羽倉稜子編 (2007)
  • Author(s): 吉松 博信
  • Publisher: 中外医学社
• [Book] カラー版糖尿病学 基礎と臨床 門脇 孝 他編 (2007)
  • Author(s): 吉松 博信
  • Publisher: 西村書店
• [Book] 内科学第9版、杉本恒明 矢崎義雄 総編集 (2007)
  • Author(s): 吉松 博信
  • Publisher: 朝倉書店