Identification and functional analysis of molecules which regulate the earliest events in lymphopoiesis
| Project/Area Number |
19591110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
YOKOTA Takafumi Osaka University, 医学系研究科, 助教 (60403200)
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| Co-Investigator(Kenkyū-buntansha) |
ORITANI Kenji 大阪大学, 医学系研究科, 講師 (70324762)
KANAKURA Yuzuru 大阪大学, 医学系研究科, 教授 (20177489)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 血液免疫学 / リンパ球 / 造血幹細胞 / Wntシグナル / 妊娠 / エストロゲン / sFRP1 |
|---|
| Research Abstract |
妊娠および性ステロイドホルモンであるエストロジェンは、リンパ球分化の極めて初期の段階を抑制することを明らかにした。そのメカニズムとして、エストロジェンが骨髄造血環境を構築する間質細胞に作用し、Wntシグナルの調節分子として知られるsoluble Frizzled-relateprotein 1(sFRP1)の分泌を亢進させること、さらにはsFRP1が未分化な造血前駆細胞に作用してリンパ球への分化を抑制することを明らかにした。
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Regulation of human B lymphopoiesis by the transforming growth factor-beta superfamily in a newly established coculture system using human mesenchymal stem cells as a supportive microenvironment2008
Author(s)
Ichii M, Oritani K, Yokota T, Nishida M, Takahashi I, Shirogane T, Ezoe S, Saitoh N, Tanigawa R, Kincade PW, Kanakura Y.
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Journal Title
Experimental Hematology 36
Pages: 587-597
Related Report
Peer Reviewed
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[Journal Article] Reduced alpha4beta1 integrin/VCAM-1 interactions lead to impaired pre-B cell repopulation in alpha 1,6-fucosyltransferase deficient mice2008
Author(s)
Li W, Ishihara K, Yokota T, Nakagawa T, Koyama N, Jin J, Mizuno-Horikawa Y, Wang X, Miyoshi E, Taniguchi N, Kondo A
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Journal Title
Glycobiology 18
Pages: 114-124
Related Report
Peer Reviewed
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[Presentation] SFRP1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis2007
Author(s)
Yokota T, Oritani K, Garrett KP, Kouro T, Nishida M, Takahashi I, Ichii M, Matsumura I, Kincade PW, Kanakura Y.
Organizer
The American Society of Hematology 49th Annual meeting
Place of Presentation
Atlanta, USA
Related Report
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[Presentation] 第37回日本免疫学会総会2007
Author(s)
Yokota T, Oritani K, Kouro T, Ichii M, Kincade PW, Kanakura Y
Organizer
SFRP1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis
Related Report
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