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Clinical significance of NKG2D ligands as a pathognomonic marker for immune-mediated marrow injury in bone marrow failure syndromes

Research Project

Project/Area Number 19591119
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionKumamoto University

Principal Investigator

KAWAGUCHI Tatsuya  Kumamoto University, 医学部・附属病院, 准教授 (50244116)

Co-Investigator(Kenkyū-buntansha) 堀川 健太郎  熊本大学, 大学院・医学薬学研究部, 助教 (40322309)
Co-Investigator(Renkei-kenkyūsha) HORIKAWA Kentaro  熊本大学, 大学院・医学薬学研究部, 助教 (40322309)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords骨髄不全症候群 / PNH / 再生不良性貧血 / 発作性夜間ヘモグロビン尿症 / NKG2D / ULBP / MICA / B / ナチュラルキラー細胞 / 発作性夜間ヘモグロゼン尿症
Research Abstract

再生不良性貧血、発作性夜間ヘモグロビン尿症および不応性貧血は、自己免疫による造血障害を共通の病態発生基盤に持つ難病(骨髄不全症候群とも呼ぶ)であるが、その分子機序の詳細は不明である。本研究では、骨髄不全症候群患者において、我々が提唱するNKG2D介在性免疫による造血障害機序の実証を試みた。その結果、約半数の患者で血球膜へのNKG2Dリガンドが発現し、さらに自己NKG2D陽性リンパ球により傷害を受けることが判明した。本成果は、NKG2Dリガンド発現が自己免疫性造血障害の臨床マーカーとして有用であるのみならず、治療の標的としての可能性を示唆している。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2009 2008 2007 Other

All Journal Article (7 results) (of which Peer Reviewed: 2 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] NKG2D-mediated immunity underlying paroxysmal nocturnal haemoglobinuria and related bone marrow failure syndromes2009

    • Author(s)
      Hanaoka H, Nakakuma H, Horikawa K, Nagakura S, Tsuzuki Y, Shimanuki M, Kojima K, Yonemura Y and Kawaguchi K.
    • Journal Title

      British Journal of Haematology (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] 発作性夜間血色素尿症の病態研究と治療の進歩.(特集 : 骨髄不全症をめぐる最近の進歩)2008

    • Author(s)
      川口辰哉、中熊秀喜
    • Journal Title

      血液・腫瘍科 56

      Pages: 189-197

    • NAID

      40019063569

    • Related Report
      2008 Final Research Report
  • [Journal Article] 発作性夜間血色素尿症の病態研究と治療の進歩. (特集 : 骨髄不全症をめぐる最近の進歩)2008

    • Author(s)
      川口辰哉
    • Journal Title

      血液・腫瘍科 56

      Pages: 189-97

    • NAID

      40019063569

    • Related Report
      2008 Annual Research Report
  • [Journal Article] New insights into molecular pathogenesis of bone marrow failure in paroxysmal nocturnal hemoglobinuria2007

    • Author(s)
      Kawaguchi T and Nakakuma H
    • Journal Title

      International Journal of Hematology 86

      Pages: 27-32

    • NAID

      10018515469

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 発作性夜間血色素尿症(PNH)の病態、診断と治療2007

    • Author(s)
      中熊秀喜、花岡伸佳、堀川健太郎、川口辰哉
    • Journal Title

      日本医事新報 No.4333

      Pages: 57-62

    • NAID

      40015353485

    • Related Report
      2008 Final Research Report
  • [Journal Article] New insights into molecular pathogenesis of bone marrow failure in paroxysmal nocturnal hemoglobinuria.2007

    • Author(s)
      Kawaguchi T., and Nakakuma H.
    • Journal Title

      International Journal of Hematology 86

      Pages: 27-32

    • NAID

      10018515469

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 発作牲夜間血色素尿症(PNH)の病態、診断と治療.2007

    • Author(s)
      中熊 秀喜, 花岡 伸佳, 堀川 健太郎, 川口 辰哉.
    • Journal Title

      日本医事新報 4333

      Pages: 57-62

    • Related Report
      2007 Annual Research Report
  • [Presentation] Safety and Efficacy of the Terminal Complement Inhibitor Eculizumab in Japanese Patients with Paroxysmal Nocturnal Hemoglobinuria: AEGIS Phase II Clinical Study Results2008

    • Author(s)
      Y. Kanakura, K. Ohyashiki, T. Shichishima, S. Okamoto, K. Ando, H. Ninomiya, T. Kawaguchi, S. Nakao, H. Nakakuma, J. Nishimura, T. Kinoshita, C. Bedrosian, M. Ellen Valentine, K. Ozawa, and M. Omine
    • Organizer
      50^<th> Annual Meeting of the American Society of Hematology
    • Place of Presentation
      San Francisco, California. USA
    • Related Report
      2008 Final Research Report
  • [Presentation] PNHや再生不良性貧血ではNKG2D介在性免疫による造血障害が発生する2008

    • Author(s)
      中熊秀喜、花岡伸佳、川口辰哉、島貫栄弥、小島研介、米村雄士、堀川健太郎
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] Safety and Efficacy of the Terminal Complement Inhibitor Eculizumab in Japanese Patients with Paroxysmal Nocturnal Hemoglobinuria : AEGIS Phase II Clinical Study Results.2008

    • Author(s)
      Y. Kanakura
    • Organizer
      50th Annual Meeting of the American Society of Hematology, 2008 ; Dec 6-9, San Francisco, California.
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] PNHや再生不良性貧血ではNKG2D介在性免疫による造血障害が発生する.2008

    • Author(s)
      川口辰哉
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] NKG2D-mediated marrow injury in paroxysmal nocturnal hemoglobinura and its related disorders2007

    • Author(s)
      Nobuyoshi Hanaoka, Tatsuya Kawaguchi, Kentaro Horikawa,Shoichi Nagakura, Sonoko Ishihara, Yasuchika Tsuzuki, Yuji Yonemura, Hideki Nakakuma
    • Organizer
      49^<th> Annual Meeting of the American Society of Hematology
    • Place of Presentation
      Atlanta, Georgia, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] NKG2D-mediated marrow injury in paroxysmal nocturnal hemoglobinura and its related disorders.2007

    • Author(s)
      Hanaoka H., Kawaguchi T., et. al.
    • Organizer
      49th Annual Meeting of the American Society of Hematology
    • Place of Presentation
      Atlanta,Georgia,USA
    • Related Report
      2007 Annual Research Report
  • [Remarks] 川口辰哉. 「難治性造血障害におけるヒトCMV糖蛋白UL16結合蛋白(ULBP)発現の病的意義」第5回感染病態研究会. 2007年9月1~2日熊本

    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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