Molecular targeting against p38MAPK in B-cell lymphoma using anti-CD19 antibody-labeled liposome

• Project/Area Number: 19591125
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Sapporo Medical University
• Principal Investigator: SATO Tsutomu Sapporo Medical University, 医学部, 助教 (40404602)
• Co-Investigator(Kenkyū-buntansha): IYAMA Satoshi 札幌医科大学, 医学部, 助教 (50398319)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 内科 / 臨床 / 癌 / 悪性リンパ腫 / p38MAPK / リポソーム / 分子標的

Research Abstract

本研究で我々は、抗CD19抗体標識ステルスリポソームをDrug Delivery Systemに用いて、B細胞性悪性リンパ腫細胞のp38MAPKを標的とする、新規分子標的治療の開発を行った。まずはin vitroでB細胞リンパ腫細胞株を用いた検討を行い、最終的には患者より採取したリンパ腫細胞をマウスに接種したin vivoの系でも良好な結果を得た。

Research Products

• [Journal Article] Drug resistance is dramatically restored by hedgehog inhibitors in CD34(+)leukemic cells (2009)
  • Author(s): Kobune M, Takimoto R, Murase K, Iyama S, Sato T, Kikuchi S, Kawano Y, Miyanishi K, Sato Y, Niitsu Y, Kato J
  • Journal Title: Cancer Sci
  • NAID: 10025145994
  • Peer Reviewed
• [Journal Article] Successful treatment for gastro-intestinal bleeding of Osler-Weber-Rendu disease by argon plasma coagulation using double-balloon enteroscopy (2008)
  • Author(s): Sato Y, Takayama T, Takahari D, Sagawa T, Sato T, Abe S, Kogawa T, Nikaido T, Miyanishi K, Takahashi S, Kato J, Niitsu Y
  • Journal Title: Endoscopy 40 Suppl 2 Pages: 228-9
  • Peer Reviewed
• [Journal Article] Treatment of hepatocellular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5-fluorouracil in mice (2008)
  • Author(s): Sagawa T, Yamada Y, Takahashi M, Sato Y, Kobune M, Takimoto R, Fukaura J, Iyama S, Sato T, Miyanishi K, Matsunaga T, Takayama T, Kato J, Sasaki K, Hamada H, Niitsu Y
  • Journal Title: Hepatology 48(3) Pages: 828-40
  • Peer Reviewed
• [Journal Article] Apoptosis supercedes necrosis in mitochondrial DNA-depleted Jurkat cells by cleavage of receptor-interacting protein and inhibition of lysosomal cathepsin (2008)
  • Author(s): Sato T, Machida T, Takahashi S, Murase K, Kawano Y, Hayashi T, Iyama S, Takada K, Kuribayashi K, Sato Y, Kobune M, Takimoto R, Matsunaga T, Kato J, Niitsu Y
  • Journal Title: J Immunol 181(1) Pages: 197-207
  • Peer Reviewed
• [Journal Article] Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells (2008)
  • Author(s): Kobune M, Kawano Y, Takahashi S, Takada K, Murase K, Iyama S, Sato T, Takimoto R, Niitsu Y, Kato J
  • Journal Title: Exp Hematol 36(9) Pages: 1121-31
  • Peer Reviewed
• [Journal Article] Successful treatment of autoimmune pancreatitis complicated with autoimmune thrombocytopenia and interstitial pneumonia by prednisolone (2008)
  • Author(s): Murase K, Matsunaga T, Hayashi T, Ishiwatari H, Araki N, Iyama S, Sato T, Kobune M, Takimoto R, Miyanishi K, Miyazaki T, Ikeda H, Kato J, Niitsu Y
  • Journal Title: Intern Med 47(11) Pages: 1033-8
  • NAID: 130000078663
  • Peer Reviewed
• [Journal Article] Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate (2008)
  • Author(s): Iyama S, Matsunaga T, Sato T, Murase K, Araki N, Takimoto R, Kobune M, Sagawa T, Takayama T, Niitsu Y
  • Journal Title: Intern Med 47(8) Pages: 791-4
  • NAID: 130000080043
  • Peer Reviewed
• [Journal Article] Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone (2008)
  • Author(s): Sato Y, Murase K, Kato J, Kobune M, Sato T, Kawano Y, Takimoto R, Takada K, Miyanishi K, Matsunaga T, Takayama T, Niitsu Y
  • Journal Title: Nat Biotechnol 26(4) Pages: 431-42
  • Peer Reviewed
• [Journal Article] Ex vivo large-scale generation of human red blood cells from cord blood CD34+ cells by co-culturing with macrophages (2008)
  • Author(s): Fujimi A, Matsunaga T, Kobune M, Kawano Y, Nagaya T, Tanaka I, Iyama S, Hayashi T, Sato T, Miyanishi K, Sagawa T, Sato Y, Takimoto R, Takayama T, Kato J, Gasa S, Sakai H, Tsuchida E, Ikebuchi K, Hamada H, Niitsu Y
  • Journal Title: Int J Hematol 87(4) Pages: 339-50
  • NAID: 10025158459
  • Peer Reviewed
• [Journal Article] Apoptosis supercedes necrosis in mitochondrial DNA-depleted Jurkat cells by cleavage of receptor-interacting protein and inhibition of lysosomal cathepsin. (2008)
  • Author(s): Sato T, et al.
  • Journal Title: J Immunol 181 Pages: 197-207
  • Peer Reviewed
• [Journal Article] Treatment of hepatocellular careinoma by AdAFPep/rep, AdAFPep/p53, and 5-fluorouracil in mice. (2008)
  • Author(s): Sagawa T, et al.
  • Journal Title: Hepatology 48 Pages: 828-40
  • Peer Reviewed
• [Journal Article] Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells. (2008)
  • Author(s): Kobune M, et al.
  • Journal Title: Exp Hematol 36 Pages: 1121-31
  • Peer Reviewed
• [Journal Article] Essential role of protein kinase C zeta in transducing a motility signal induced by superoxide and a chemotactic peptide, fMLP (2007)
  • Author(s): Kuribayashi K, Nakamura K, Tanaka M, Sato T, Kato J, Sasaki K, Takimoto R, Kogawa K, Terui T, Takayama T, Onuma T, Matsunaga T, Niitsu Y
  • Journal Title: J Cell Biol 176(7) Pages: 1049-60
  • Peer Reviewed
• [Journal Article] Essential role of protein kinase C zeta in transducing a motility signal induced by superoxide and a chemotactic peptide, fMLP. (2007)
  • Author(s): Kuribayashi K, et. al.
  • Journal Title: J Cell Biol. 176 Pages: 1049-60
  • Peer Reviewed
• [Presentation] ミトコンドリアDNA欠損Jurkat亜株において、アポトーシスシグナルはカテプシン活性の抑制によりネクローシスシグナルを凌駕する (2008)
  • Author(s): 佐藤勉、町田卓郎、高橋祥、村瀬和幸、井山諭、佐藤康史、小船雅義、瀧本理修、松永卓也、加藤淳二
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-28