| Project/Area Number |
19591128
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka City University |
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Principal Investigator |
HINO Masayuki Osaka City University, 大学院・医学研究科, 教授 (50244637)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMAE Hirohisa 大阪市立大学, 大学院・医学研究科, 講師 (30364003)
KOH Ki-Ryang 大阪市立大学, 大学院・医学研究科, 講師 (10315997)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 造血幹細胞移植 / 合併症 / ドナー / 心拍変動解析 / 心臓 / 肺 / 造血器疾患 |
|---|
| Research Abstract |
In this study, clinical trial of angiotensin II receptor blocker, Valsartan, to prevent chronic cardiotoxic damage following standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, prednisolong±rituximab was performed. This study shows that (1)reduced-intensity allogeneic stem cell transplantation (RIST) is well-tolerated in patients with cardiac dysfunction ; (2)monitoring HRV may be useful in predicting stem cell transplantation is a useful, noninvasive predictor for the development of bronchiolitis obliterans syndrome (BOS) and idiopathic pneumonia syndrome (IPS) ; (4)heart rate variability analysis is useful in evaluating and predicting the adverse effects of cardiovascular complications in peripheral blood stem cell harvest.
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