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Evaluation and treatment for complications of hematopoietic stem cell transplantation

Research Project

Project/Area Number 19591128
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionOsaka City University

Principal Investigator

HINO Masayuki  Osaka City University, 大学院・医学研究科, 教授 (50244637)

Co-Investigator(Kenkyū-buntansha) NAKAMAE Hirohisa  大阪市立大学, 大学院・医学研究科, 講師 (30364003)
KOH Ki-Ryang  大阪市立大学, 大学院・医学研究科, 講師 (10315997)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords造血幹細胞移植 / 合併症 / ドナー / 心拍変動解析 / 心臓 / 肺 / 造血器疾患
Research Abstract

In this study, clinical trial of angiotensin II receptor blocker, Valsartan, to prevent chronic cardiotoxic damage following standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, prednisolong±rituximab was performed. This study shows that (1)reduced-intensity allogeneic stem cell transplantation (RIST) is well-tolerated in patients with cardiac dysfunction ; (2)monitoring HRV may be useful in predicting stem cell transplantation is a useful, noninvasive predictor for the development of bronchiolitis obliterans syndrome (BOS) and idiopathic pneumonia syndrome (IPS) ; (4)heart rate variability analysis is useful in evaluating and predicting the adverse effects of cardiovascular complications in peripheral blood stem cell harvest.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (9 results) Remarks (3 results)

  • [Journal Article] Heart rate variability during and after peripheral blood stem cell leukapheresis in autulogous transplant patients and allogeneic transplant donors.2010

    • Author(s)
      Nakane T, Nakamae H, Koh H, Nakamae M, Aimoto R, Terada Y, Koh KR, Yamane T, Hino M
    • Journal Title

      Int J Hematol 91

      Pages: 478-484

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heart rate variability during and after peripheral blood stem cell leukapheresis in autulogous transplant patients and allogeneic transplant donors.2010

    • Author(s)
      Nakane T, Nakamae H, Koh H, Nakamae M, Aimoto R, Terada Y, Koh KR, Yamane T, Hino M
    • Journal Title

      Int J Hematol (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cadiac and autonomic nerve function after reduced-intensity stem cell transplantation for hematologic malignancy in patients with pre-transplant cardiac dysfunction.2009

    • Author(s)
      Nakane T, Nakamae H, Mori T, Yamaguchi H, Kobayashi Y, Amimoto M, Sakamoto E, Terada Y, Nakamae M, Koh KR, Yamane T, Yoshiyama M, Hino M
    • Journal Title

      Ann Hematol 88

      Pages: 871-879

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CNS complications of hematopoietic stem cell transplantation.2009

    • Author(s)
      Nishiguchi T, Mochizuki K, Shakudo M, Takeshita T, Hino M, Inoue Y
    • Journal Title

      Am J Roentgenol 192

      Pages: 1003-1011

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of relative dose intensity (RDI) in CHOP combined with rituximab (R-CHOP) on survival in diffuse large B-cell lymphoma.2009

    • Author(s)
      Terada Y, Nakamae H, Aimoto R, Kanasima H, Sakamoto E, Aimoto M, Inoue E, Koh H, Nakane T, Takeoka Y, Ohsawa M, Koh KR, Yamane T, Nakao Y, Ohta K, Mugitani A, Teshima H, Hino M
    • Journal Title

      J Exp Clin Cancer Res. 28

      Pages: 116-116

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of intravenous itraconazole as empirical antifungal therapy for persistent fever in neutropenic patients with hematological malignancies in Japan.2009

    • Author(s)
      Ohta K, Nishiki-Kosaka S, Nakao Y, Kumura T, Hagihara K, Sakamoto E, Okamoto S, Hirose A, Aoyama Y, Yamamura R, Hayashi Y, Umemoto Y, Terada Y, Takeoka Y, Nakane T, Koh H, Hino M
    • Journal Title

      Int J Hematol 89

      Pages: 649-655

    • NAID

      10025161974

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cadiac and autonomic nerve function after reduced-intensity stem cell transplantation for hematologic malignancy in patients with pre-transplant cardiac dysfunction.2009

    • Author(s)
      Nakane T, Nakamae H, Mori T, Yamaguchi H, Kobayashi Y, Amimoto M, Sakamoto E, Terada Y, Nakamae M, Koh K-R, Yamane T, Yoshiyama M, Hino M.
    • Journal Title

      Ann Hematol 88

      Pages: 871-879

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CNS complications of hematopoietic stem cell transplantation.2009

    • Author(s)
      Nishiguchi T, Mochizuki K, Shakudo M, Takeshita T, Hino M, Inoue Y.
    • Journal Title

      Am J Roentgenol 192

      Pages: 1003-1011

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac and autonomic nerve function after reduced-intensity stem cell transplantation for hematologic malignancy in patients with pre-transplant cardiac dysfunction.2009

    • Author(s)
      Takahiko Nakane, et al
    • Journal Title

      Annals of Hematology (Epub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of serum surfactant protein D level prior to transplant for the development of bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation.2009

    • Author(s)
      Takahiko Nakane, et al
    • Journal Title

      Bone Marrow Transplantation 42

      Pages: 43-49

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of serum surfactant protein D level prior to transplant for the development of bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation.2008

    • Author(s)
      Nakane T, Nakamae H, Kamoi H, Koh H, Takeoka Y, Sakamoto E, Kanashima H, Nakamae M, Ohta K, Terada Y, Koh KR, Yamane T, Hino M
    • Journal Title

      Bone Marrow Transplant 42

      Pages: 43-49

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Current and future perspectives on the TARGET system : the registration system for Glivec((R)) established by the JSH.2008

    • Author(s)
      Kizaki M, et al
    • Journal Title

      International Journal of Hematology 88

      Pages: 409-417

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of serum surfactant protein D level prior to transplant for the development of bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation.2008

    • Author(s)
      Takahiko Nakane
    • Journal Title

      Bone Marrow Transplantation

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] シクロスポリン(CsA)+短期メソトレキセート(sMTX)をGVHD予防とした非T細胞除去・非TBI下での骨髄非破壊的非血縁者間同種骨髄移植(u-RIST)の検討2010

    • Author(s)
      中根孝彦, 中前博久, 康秀男, 中前美佳, 林良樹, 西本光孝, 吉村卓朗, 井上恵里, 井上敦司, 相本蘭, 相本瑞樹, 寺田芳樹, 高起良, 山根孝久, 日野雅之
    • Organizer
      第32回日本造血細胞移植学会
    • Place of Presentation
      浜松
    • Related Report
      2009 Final Research Report
  • [Presentation] Ara-C+CY+TBIを前処置とした非血縁臍帯血移植の予後因子の当科での検討2010

    • Author(s)
      林良樹, 中根孝彦, 中前博久, 康秀男, 中前美佳, 西本光孝, 吉村卓朗, 井上恵里, 井上敦司, 相本蘭, 相本瑞樹, 寺田芳樹, 高起良, 山根孝久, 日野雅之
    • Organizer
      第32回日本造血細胞移植学会
    • Place of Presentation
      浜松
    • Related Report
      2009 Final Research Report
  • [Presentation] あなたならどうする造血幹細胞移植~HLA適合血縁者が得られない時~2009

    • Author(s)
      中前博久
    • Organizer
      第92回近畿血液学地方会
    • Place of Presentation
      京都
    • Year and Date
      2009-12-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 非血縁者間末梢血幹細胞移植2009

    • Author(s)
      日野雅之
    • Organizer
      第31回日本アフェレーシス学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 非血縁者間骨髄非破壊的同種骨髄・末梢血造血幹細胞移植の現状合同シンポジウム「非血縁PBSCTに向けて」骨髄移植推進財団(JMDP)における取組の現状と将来展望2009

    • Author(s)
      日野雅之
    • Organizer
      第31回日本造血細胞移植学会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] 急性GVHDに対する初期治療としてのステロイドおよびミコフェノール酸モフェチル(MMF)併用療法の安全性および有効性に関する検討2009

    • Author(s)
      中根孝彦, 武岡康信, 中前博久, 相本瑞樹, 康秀男, 百瀬大, 岡本秀一郎, 和田恵里, 守口蘭, 梅本由香里, 寺田芳樹, 高起良, 山根孝久, 日野雅之
    • Organizer
      第31回日本造血細胞移植学会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] 非血縁PBSCTに向けて〜骨髄移植推進財団における取り組みの現状と将来展望2009

    • Author(s)
      日野雅之
    • Organizer
      第31回日本造血細胞移植学会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] 心機能低下5症例に対する骨髄非破壊的同種造血幹細胞移植(^)後の心機能および自律神経機能の解析2008

    • Author(s)
      中根 孝彦
    • Organizer
      日本造血細胞移植学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 心機能低下5症例に対する骨髄非破壊的同種造血幹細胞移植(RIST)後の心機能および自律神経機能の解析2008

    • Author(s)
      中根孝彦, 中前博久, 相本瑞樹, 阪本親彦, 赤澤結貴, 和田恵里, 康秀男, 武岡康信, 寺田芳樹, 高起良, 山根孝久, 日野雅之
    • Organizer
      第30回日本造血細胞移植学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://medwebsv.med.osaka-cu.ac.jp/labmed/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://medwebsv.med.osaka-cu.ac.jp/labmed/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://medwebsv.med.osaka-cu.ac.jp/labmed/index.html

    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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