Evaluation and treatment for complications of hematopoietic stem cell transplantation
Project/Area Number |
19591128
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Osaka City University |
Principal Investigator |
HINO Masayuki Osaka City University, 大学院・医学研究科, 教授 (50244637)
|
Co-Investigator(Kenkyū-buntansha) |
NAKAMAE Hirohisa 大阪市立大学, 大学院・医学研究科, 講師 (30364003)
KOH Ki-Ryang 大阪市立大学, 大学院・医学研究科, 講師 (10315997)
|
Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 造血幹細胞移植 / 合併症 / ドナー / 心拍変動解析 / 心臓 / 肺 / 造血器疾患 |
Research Abstract |
In this study, clinical trial of angiotensin II receptor blocker, Valsartan, to prevent chronic cardiotoxic damage following standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, prednisolong±rituximab was performed. This study shows that (1)reduced-intensity allogeneic stem cell transplantation (RIST) is well-tolerated in patients with cardiac dysfunction ; (2)monitoring HRV may be useful in predicting stem cell transplantation is a useful, noninvasive predictor for the development of bronchiolitis obliterans syndrome (BOS) and idiopathic pneumonia syndrome (IPS) ; (4)heart rate variability analysis is useful in evaluating and predicting the adverse effects of cardiovascular complications in peripheral blood stem cell harvest.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Cadiac and autonomic nerve function after reduced-intensity stem cell transplantation for hematologic malignancy in patients with pre-transplant cardiac dysfunction.2009
Author(s)
Nakane T, Nakamae H, Mori T, Yamaguchi H, Kobayashi Y, Amimoto M, Sakamoto E, Terada Y, Nakamae M, Koh KR, Yamane T, Yoshiyama M, Hino M
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Journal Title
Ann Hematol 88
Pages: 871-879
Related Report
Peer Reviewed
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[Journal Article] Impact of relative dose intensity (RDI) in CHOP combined with rituximab (R-CHOP) on survival in diffuse large B-cell lymphoma.2009
Author(s)
Terada Y, Nakamae H, Aimoto R, Kanasima H, Sakamoto E, Aimoto M, Inoue E, Koh H, Nakane T, Takeoka Y, Ohsawa M, Koh KR, Yamane T, Nakao Y, Ohta K, Mugitani A, Teshima H, Hino M
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Journal Title
J Exp Clin Cancer Res. 28
Pages: 116-116
Related Report
Peer Reviewed
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[Journal Article] Efficacy and safety of intravenous itraconazole as empirical antifungal therapy for persistent fever in neutropenic patients with hematological malignancies in Japan.2009
Author(s)
Ohta K, Nishiki-Kosaka S, Nakao Y, Kumura T, Hagihara K, Sakamoto E, Okamoto S, Hirose A, Aoyama Y, Yamamura R, Hayashi Y, Umemoto Y, Terada Y, Takeoka Y, Nakane T, Koh H, Hino M
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Journal Title
Int J Hematol 89
Pages: 649-655
NAID
Related Report
Peer Reviewed
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[Journal Article] Cadiac and autonomic nerve function after reduced-intensity stem cell transplantation for hematologic malignancy in patients with pre-transplant cardiac dysfunction.2009
Author(s)
Nakane T, Nakamae H, Mori T, Yamaguchi H, Kobayashi Y, Amimoto M, Sakamoto E, Terada Y, Nakamae M, Koh K-R, Yamane T, Yoshiyama M, Hino M.
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Journal Title
Ann Hematol 88
Pages: 871-879
Related Report
Peer Reviewed
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[Journal Article] Prognostic value of serum surfactant protein D level prior to transplant for the development of bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation.2008
Author(s)
Nakane T, Nakamae H, Kamoi H, Koh H, Takeoka Y, Sakamoto E, Kanashima H, Nakamae M, Ohta K, Terada Y, Koh KR, Yamane T, Hino M
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Journal Title
Bone Marrow Transplant 42
Pages: 43-49
Related Report
Peer Reviewed
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[Presentation] シクロスポリン(CsA)+短期メソトレキセート(sMTX)をGVHD予防とした非T細胞除去・非TBI下での骨髄非破壊的非血縁者間同種骨髄移植(u-RIST)の検討2010
Author(s)
中根孝彦, 中前博久, 康秀男, 中前美佳, 林良樹, 西本光孝, 吉村卓朗, 井上恵里, 井上敦司, 相本蘭, 相本瑞樹, 寺田芳樹, 高起良, 山根孝久, 日野雅之
Organizer
第32回日本造血細胞移植学会
Place of Presentation
浜松
Related Report
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[Presentation] Ara-C+CY+TBIを前処置とした非血縁臍帯血移植の予後因子の当科での検討2010
Author(s)
林良樹, 中根孝彦, 中前博久, 康秀男, 中前美佳, 西本光孝, 吉村卓朗, 井上恵里, 井上敦司, 相本蘭, 相本瑞樹, 寺田芳樹, 高起良, 山根孝久, 日野雅之
Organizer
第32回日本造血細胞移植学会
Place of Presentation
浜松
Related Report
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[Presentation] 急性GVHDに対する初期治療としてのステロイドおよびミコフェノール酸モフェチル(MMF)併用療法の安全性および有効性に関する検討2009
Author(s)
中根孝彦, 武岡康信, 中前博久, 相本瑞樹, 康秀男, 百瀬大, 岡本秀一郎, 和田恵里, 守口蘭, 梅本由香里, 寺田芳樹, 高起良, 山根孝久, 日野雅之
Organizer
第31回日本造血細胞移植学会
Place of Presentation
札幌
Related Report
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[Presentation] 心機能低下5症例に対する骨髄非破壊的同種造血幹細胞移植(RIST)後の心機能および自律神経機能の解析2008
Author(s)
中根孝彦, 中前博久, 相本瑞樹, 阪本親彦, 赤澤結貴, 和田恵里, 康秀男, 武岡康信, 寺田芳樹, 高起良, 山根孝久, 日野雅之
Organizer
第30回日本造血細胞移植学会総会
Place of Presentation
大阪
Related Report
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