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Molecular mechanism of Sjogren's syndrome : Immune response to M3R

Research Project

Project/Area Number 19591151
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionUniversity of Tsukuba

Principal Investigator

SUMIDA Takayuki  University of Tsukuba, 大学院・人間総合科学研究科, 教授 (00183054)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsシェーグレン症候群 / T細胞 / 自己抗体 / T細胞エピトープ / アナログペプチド / M3R / 抗M3R抗体 / B細胞エピトープ / 唾液分泌 / 唾液腺炎モデルマウス / ムスカリン作働性アセチルコリン受容体(M3R) / 発症機構 / 抗原特異的制御
Research Abstract

シェーグレン症候群(SS)の発症機序の解明、それに基づく抗原特異的治療の開発を目的として、ムスカリン作働性アセチルコリン受容体3(M3R)に対する免疫応答を明らかにすることを目的とした。その結果、SS患者末梢血中には多彩なB細胞エピトープに対する抗M3R抗体が存在し、唾液分泌に対する機能はM3R上のB細胞エピトープにより異なる事が明らかになった。さらに、M3Rペプチドを免疫することによりSSに類似した唾液腺炎を発症するモデルマウスの作成に成功した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (70 results)

All 2009 2008 2007

All Journal Article (24 results) (of which Peer Reviewed: 23 results) Presentation (42 results) Book (4 results)

  • [Journal Article] B cells play a crucial role as antigen-presenting cells and collaborate with inflammatory cytokines in glucose-6-phosphate isomerase-induced arthritis2009

    • Author(s)
      Tanaka-Watanabe Y, Matsumoto I, Iwanami K, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Journal Title

      Clin. Exp. Immunol 155

      Pages: 285-294

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population2009

    • Author(s)
      Ito I, Kawasaki A, Ito S, Hayashi T, Goto D, Matsumoto I, Tsutsumi A, Hom G, Graham RR, Takasaki Y, Hashimoto H, Ohashi J, Behrens TW, Sumida T, Tsuchiya N.
    • Journal Title

      Arthritis Rheum 60

      Pages: 553-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] B cells play a crucial role as antigen-presenting cells and collaborate with in flammatory cytokines in glucose-6-phosphate isomerase-induced arthritis.2009

    • Author(s)
      Tanaka-Watanabe Y, Matsumoto I, Iwanami K, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Journal Title

      Clin. Exp. Immunol. 155

      Pages: 285-294

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population.2009

    • Author(s)
      Ito I, Kawasaki A, Ito S. Hayashi T, Goto D, Matsumoto I, Tsutsumi A, Hom G, Graham RR, Takasaki Y, Hashimoto H, Ohashi J, Behrens TW, Sumida T, Tsuchiya N.
    • Journal Title

      Arthritis Rheum. 60

      Pages: 553-558

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arthritogenic T cell epitope in glucose-6-phosphate isomerase (GPI)-induced arthritis2008

    • Author(s)
      Iwanami K, Matsumoto I, Tanaka Y, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Journal Title

      Arthritis Res Ther 10(Epub)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population : a case-control association study of STAT1-STAT4 region2008

    • Author(s)
      Arthritis Res TherKawasaki A, Ito I, Hikami K, Ohashi J, Hayashi T, Goto D, Matsumoto I, Ito S, Tsutsumi A, Koga M, Arinami T, Graham R R, Hom G, Takasaki Y, Hashimoto H, Behrens T W, Sumida T and Tsuchiya N.
    • Journal Title

      Arthritis Res Ther 10(Epub)

    • NAID

      120007138342

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Muscarinic-3 acetylcholine receptor autoantibody in patients with systemic sclerosis : contribution to severe gastrointestinal tract dysmotility2008

    • Author(s)
      Kawaguchi Y, Wakamatsu E, Matsumoto I, Nishimagi E, Kamatani N, Satoh T, Kuwana M, Sumida T, Hara M.
    • Journal Title

      Ann. Rheum. Dis. Sep1.Epub

      Pages: 1-1

    • Related Report
      2008 Final Research Report
  • [Journal Article] Therapeutic effects of antibodies to TNF alpha and IL-6 and CTLA-4 Ig in mice with glucose-6-phosphate isomerase-induced arthritis2008

    • Author(s)
      Matsumoto I, Zhang H, Yasukochi T, Iwanami K, Tanaka Y, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Journal Title

      Arthritis Res Ther 10(Epub)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Invariant NKT cells produce IL-17 through IL-23-dependent and-independent pathways with potential modulation of Th17 response in collagen-induced arthritis2008

    • Author(s)
      Yoshiga Y, Goto D, Segawa S, Ohnishi Y, I. Yoshiga Y, Goto D, Segawa S, Ohnishi Y, I. Matsumoto I, Ito S, Tsutsumi A, Taniguchi M, Sumida T.
    • Journal Title

      Int. J. Mol. Med 22

      Pages: 369-374

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role of IL-6/IL-17 cytokine axis in the induction of arthritis by glucose-6-phosphate-isomerase2008

    • Author(s)
      Iwanami K, Matsumoto I, Watanabe Y, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T.
    • Journal Title

      Arthritis Rheum 58

      Pages: 754-763

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of autoantibodies to muscarinic-3 acetylcholine receptor in patients with juvenile-onset Sjogren's syndrome2008

    • Author(s)
      Nakamura Y, Wakamatsu E, Matsumoto I, Tomiita M, Kohno Y, Mori M, Yokota S, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Journal Title

      Ann. Rheum. Dis 67

      Pages: 136-137

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Arthritogenic T cell epitope in glucose-6-phosphate isomerase (GPI)-induced arthritis.2008

    • Author(s)
      Iwanami K, Matsum I, Tanaka Y, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Journal Title

      Arthritis Res. Ther. 10(Epub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of STAT4 polymorphisms in systemic lupus erytheMatosus in a Japanese population: a case-control association study of STAT1-STAT4 region.2008

    • Author(s)
      Kawasaki A, Ito I, Hikami K, Ohashi J, Hayashi T,Goto D, Matsumoto I, Ito S, Tsutsumi A, Koga M, Arinami T, Graham R R, Hom G, Takasaki Y, Hashimoto H, Behrens T W, Sumida T and Tsuchiya N.
    • Journal Title

      Arthritis Res Ther 10(Epub)

    • NAID

      120007138342

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscarinic-3 acetylcholine receptor autoantibody in patients with systemic sclerosis: contribution to severe gastrointestinal tract dysmotility.2008

    • Author(s)
      Kawaguchi Y, Wakamatsu E, Matsumoto I, Nishimagi E, Kamatani N, Satoh T, Kuwana M, Sumida T, Hara M.
    • Journal Title

      Ann. Rheum. Dis. Sep1(Epub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effects of antibodies to: TNF alpha and IL-6 and CTLA-4 Ig in mice with glucose-6-phosphate isomerase-induced arthritis.2008

    • Author(s)
      Matsumoto I, Zhang H, Yasukochi I, wanami K, Tanaka Y, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Journal Title

      Arthritis Res Ther 10(Epub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Invariant NKT cells produce IL-17 through IL-23-dependent and-independent pathways with potential modulation of Th17 response in collagen-induced arthritis.2008

    • Author(s)
      Yoshiga Y, Goto D, Segawa S, Ohnishi Y, I. Matsumoto I, Ito S, Tsutsumi A, Taniguchi M and SumidaT.
    • Journal Title

      Int. J. Mol. Med. 22

      Pages: 369-374

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role of IL-6/IL-17 cytokine axis in the induction of arthritis by glucose-6-phosphate-isomerase.2008

    • Author(s)
      Iwanami K, Matsumoto I, Watanabe Y, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, SumTida T.
    • Journal Title

      Arthritis Rheum. 58

      Pages: 754-763

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visfatin (pre-B cell colony-enhancing factor) gene expressionin patients with rheumatoid arthritis.2008

    • Author(s)
      Matsui H, Tsutsumi A, Sugihara M, Suzuki T, Iwanami K, Kohno M, Goto D, Matsumoto I, Ito S, Sumida T.
    • Journal Title

      Ann. Rheum. Dis. 67

      Pages: 571-572

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of autoantibodies to muscarinic-3 acetylcholine receptor in patients with juvenile-onset Sjogren's syndrome2008

    • Author(s)
      Nakamura Y. Wakamatsu E, Matsumoto I, Tomiita M, Kohno Y, Mori M, Yokota S, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Journal Title

      Ann. Rheum. Dis. 67

      Pages: 136-137

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of autoantibodies to muscarinic 3 acetylcholine receptor in patients with・juvenile Sjogren's syndrome.2008

    • Author(s)
      Nakamura, Y., et. al.
    • Journal Title

      Ann. Rheum. Dis. 67

      Pages: 136-137

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of infliximab therapy on gene expression levels of TNF-alpha, TTP, TIA-1 and Hu antigen R in patients with rheumatoid arthritis2007

    • Author(s)
      Sugihara M, Tsutsumi A, Suzuki E, Wakamatsu E, Suzuki T, Ogishima H, Hayashi T, Chino Y, Ishii W, Mamura M, Goto D, Matsumoto I, Ito S, Sumida T.
    • Journal Title

      Arthritis Rheum 56

      Pages: 2160-2169

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA microarray analysis of labial salivary glands of patients with Sjogren's syndrome2007

    • Author(s)
      Wakamatsu E, Nakamura Y, Matsumoto I, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Journal Title

      Ann. Rheum. Dis 66

      Pages: 844-845

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA microarray analysis of labial salivary glands of patients with Sjogren's syndrome.2007

    • Author(s)
      Wakamatsu, E., et. al.
    • Journal Title

      Ann. Rheum. Dis. 66

      Pages: 844-845

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of infliximab therapy on gene expression levels of TNF α, TTP, TIA-1 and HuR in patients with rheumatoid arthritis.2007

    • Author(s)
      Sugihara, M., et. al.
    • Journal Title

      Arthritis Rheum. 56

      Pages: 2160-2169

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] The Expression of MicroRNA-424 in Rheumatoid Arthritis2008

    • Author(s)
      Yoshitaka T, Nakasa T, Inoue A, Okubo A, Takemoto F, Miyaki S, Nishida K, Ochi M, Ozaki T, Sumida T, Asahara H.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] The Pathogenesis of Anti-M3 Muscarinic Acetylcholine Receptor Antibodies in Patients with Sjogren's Syndrome2008

    • Author(s)
      Tsuboi H, Matsumoto I, Wakamatsu E, Iizuka M, Nakamura Y, Hayashi T, Goto D, Ito S, Sumida T.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Establishment Of New Murine Model For Sjogren'S Syndrome Using M3 Muscarinic Acethylcholine Receptor Knockout Mice2008

    • Author(s)
      Wakamatsu E, Matsumoto I, Iizuka M, Tsuboi H, Nakamura Y, Hayashi T, Goto D, Ito S, Sumida T.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] The Expression of MicroRNA-424 in Rheumatoid Arthritis.2008

    • Author(s)
      Yoshitaka T, Nakasa T, Inoue A, Okubo A, Takemoto F, Miyaki S, Nishida K, Ochi M, Ozaki T, Sumida T, Asahara H.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Pathogenesis of Anti-3 Muscarinic Acetylcholine Receptor Antibodies in Patients with Sjogren's Syndrome.2008

    • Author(s)
      Tsuboi H, Matsumoto I, Wakamatsu E, Iizuka M, Nakamura Y, Hayashi T, Goto D, Ito S, Sumida T.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Establishment Of New Murine Model For Sjogren'S Syndrome Using M3 Muscarinic Acethylcholine Receptor Knockout Mice.2008

    • Author(s)
      Wakamatsu E, Matsumoto I, Iizuka M, Tsuboi H, Nakamura Y, Hayashi T, Goto D, Ito S, Sumida T.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Overexpression Of TNFalpha-induced-adipose Related Protein (TIARP) In Joints With Autoimmune Arthritis Mediated By Glucose-6-phophate Isomerase2008

    • Author(s)
      Inoue A, Matsumoto I, Iwanami K, Tanaka-Watanabe Y, Hayashi T, Goto D, Ito S, Sumida T.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-27
    • Related Report
      2008 Final Research Report
  • [Presentation] Overexpression Of TNFalpha-induced-adipose Related Protein (TIARP) In Joints With Autoimmune Arthritis Mediated By Glucose-6-phophate Isomerase.2008

    • Author(s)
      Inoue A, Matsutomo, I, Iwanami K, Tanaka-Watanabe Y, Hayashi T, Goto D, Ito S, Sumida T.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Replication of the Association between C8orf13-BLK Region, Systemic Lupus Erythematosus in a Japanese Population2008

    • Author(s)
      Ito I, Kawasaki A, Hayashi T, Matsumoto I, Ito S, Tsutsumi A, Ohashi J, Hom G, Graham R R, Takasaki Y, Hashimoto H, Behrens TW, Sumida T, Tsuchiya N.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Association of STAT4 polymorphisms with Systemic Lupus Erythematosus in a Japanese Population2008

    • Author(s)
      Kawasaki A, Ito I, Hikami K, Hayashi T, Matsumoto I, Ito S, Tsutsumi A, Koga M, Arinami T, Graham R R, Hom G, Ohashi J, Takasaki Y, Hashimoto H, Behrens TW, Sumida T, Tsuchiya N.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Use of Laser Microdissection in the Analysis of Renal-infiltrating T cells in lupus nephritis2008

    • Author(s)
      Wang Y, Ito S, Chino Y, Goto D, Matsumoto I, Hayashi T, Sumida T.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Muscarinic-3 Acetylcholine Receptor Autoantibody in Patients with Systemic Sclerosis2008

    • Author(s)
      Kawaguchi Y, Nakamura Y, Matsumoto I, Ota Y, Nishimagi E, Kamatani N, Satoh T, Kuwana M, Sumida T, Hara M.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Replication of the Association between C8orf13-BLK Region and Systemic Lupus Erythematosus in a Japanese Population.2008

    • Author(s)
      Ito I, Kawasaki A Hayashi T, Matsumoto I, Ito S, Tsutsumi A, Ohashi J, Hom G, Graham R R, Takasaki Y, Hashimoto H, Behrens TW, Sumida T, Tsuchiya N.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Association of STAT4 polymorphisms with Systemic Lupus Erythematosus in a Japanese Population.2008

    • Author(s)
      Kawasaki A, Ito I, Hikami K, Hayashi T, Matsumoto I, Ito S, Tsutsumi A, Koga M, Arinami T, Graham R R, Hom G, Ohashi J, Takasaki Y, Hashimoto H, Behrens TW, Sumida T, Tsuchiya N.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Use of Laser Microdissection in the Analysis of Renal-infiltratsing T cell in lupus nephritis.2008

    • Author(s)
      Wang Y, Ito S, Chino Y, Goto D, Matsumoto I, Hayashi T, Sumida T.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Muscarinic-3 Acetylcholine Receptor Autoantibody in Patients with Systemic Sclerosis.2008

    • Author(s)
      Kawaguchi Y, Nakamura Y, Matsumoto I, Ota Y, Nishimagi E, Kamatani N, Satoh T, Kuwana M, Sumida T, Hara M.
    • Organizer
      2008 ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Induction of experimental autoimmune sialoadenitis using organ-specific autoantigen knockout mice2008

    • Author(s)
      Wakamatsu E, Matsumoto I, Iizuka M, Tsuboi H, Nakamura Y, Hayashi T, Goto D, Ito S, Sumida T.
    • Organizer
      APLAR2008
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Evaluation of anti-TNF biologics on rheumatoid arthritis using the new low-field extremity MRI and scoring system2008

    • Author(s)
      Suzuki T, Handa S, Kose K, Hayashi T, Goto D, Matsumoto I, Ito S, Sumida T.
    • Organizer
      APLAR2008
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Induction of experimental autoimmune sialoadenitis using organ-specific autoantigen knockout mice.2008

    • Author(s)
      Wakamatsu E, Matsumoto I, Iizuka M, Tsuboi H, Nakamura Y, Hayashi T, Goto D, Ito S, Sumida T.
    • Organizer
      APLAR2008
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Evaluation of anti-TNF biologiics on rheumatoid arthritis using the new low-field extremity MRI and scoring system.APLAR20082008

    • Author(s)
      Suzuki T, Hand S, Kose K, Hayashi T, Goto D, Matsumoto I, Ito S, Sumida T.
    • Organizer
      APLAR2008
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] TNF alpha induces human six-transmembrane epitherial antigen of prostate 4 in rheumatoid synovium2008

    • Author(s)
      Tanaka-Watanabe Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Hayashi T, Goto D, Ito S, Sumida T.
    • Organizer
      APLAR2008
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-24
    • Related Report
      2008 Final Research Report
  • [Presentation] TNF alpha induces human six-transmembrane epitherial antigen of prostate 4 in rheumatoid synovium.2008

    • Author(s)
      Tanaka-Watanabe Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Hayashi T, Goto. D, Ito S, Sumida T.
    • Organizer
      APLAR2008
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Exploring the Role of TIARP(TNFαInduced Adipose Related Protein ) in Autoimmune Arthritis Mediated Driven by Glucose-6-phosphate Isomerase2007

    • Author(s)
      Inoue A, Matsumoto I, Iwanami K, Tanaka-Watanabe Y, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Organizer
      2007ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      US
    • Year and Date
      2007-11-10
    • Related Report
      2008 Final Research Report
  • [Presentation] A Novel Role For Natural Killer T Cells As Activators And Producers Of Interleukin-17 In The Pathogenesis Of Collagen-induced Arthritis2007

    • Author(s)
      Yoshiga Y, Goto D, Segawa S, Matsumoto I, Ito S, Tsutsumi A, Sumida T.
    • Organizer
      2007ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      US
    • Year and Date
      2007-11-10
    • Related Report
      2008 Final Research Report
  • [Presentation] The Function of CD1d Variants in Patients with Autoimmune Disease2007

    • Author(s)
      Goto D, Yoshiga Y, Segawa S, Matsumoto I, Ito S, Tsutsumi A, Sumida T.
    • Organizer
      2007ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      US
    • Year and Date
      2007-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] B Cell Have Crucial Role as Autoantibody Producers in Arthritis Mediates by Glucose-6-phosphate Isomerase2007

    • Author(s)
      Tanaka-Watanabe Y, Matsumto I, Iwanami K, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Organizer
      2007ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      US
    • Year and Date
      2007-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Therapeutic Effects of Tnfα Antagonist, IL-6 Antagonist and Ctla-4 Ig in Glucose-6-phosphate Isomerase Induced Arthritis2007

    • Author(s)
      Matsumoto I, Iwanami K, Tanaka Y, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Organizer
      2007ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      US
    • Year and Date
      2007-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Anti-glucose-6-phosphate Isomerase, Anti-cyclic Citrullinated Peptide Antibodies and HLA-DRB1 Genotypes in Japanese Patients with Early Rheumatoid Arthritis2007

    • Author(s)
      Furuya T, Matsumoto I, Tsuchiya N, Hakoda M, Ichikawa N, Yago T, Nanke Y, Sumida T, Kamatani N, Kotake S.
    • Organizer
      2007ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      US
    • Year and Date
      2007-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] New Murine Model for Sjogren's Syndrome Established by M3 Muscarinic Acethylcholine Receptor Immunization.2007

    • Author(s)
      Wakamatsu E, Nakamura Y, Matsumoto I, Tsuboi H, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Organizer
      2007ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      US
    • Year and Date
      2007-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression of the Interleukin 17 Gene in Patients with Rheumatoid Arthritis2007

    • Author(s)
      Kohno M, Tsutsumi A, Matsui H, Sugihara M, Mamura M, Suzuki T, Goto D, Matsumoto I, Ito S, Sumida T.
    • Organizer
      2007ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      US
    • Year and Date
      2007-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Tristetraprolin(TTP) Gene Polymorphisms in Patients with Rheumatoid Arthritis and Healthy Individuals2007

    • Author(s)
      Suzuki T, Tsutsumi A, Sugihara M, Kohno M, Goto D, Matsumoto I, Ito S, Sumida T.
    • Organizer
      2007ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      US
    • Year and Date
      2007-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis of T Cells Infiltrating in Kidneys of MRL/lpr Mouse by Laser-Microdissection Method2007

    • Author(s)
      Wang Y, Ito S, Chino Y, Goto D, Matsumoto I, Tsutsumi A, Sumida T.
    • Organizer
      2007ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      US
    • Year and Date
      2007-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Crucial Role of IL-6/IL-17 Axis in the Generation of GPI-induced Arthritis2007

    • Author(s)
      Iwanami K, Matsumoto I, Watanabe-Tanaka Y, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Organizer
      2007ANNUAL SCIENTIFIC MEETING on the ACR
    • Place of Presentation
      US
    • Year and Date
      2007-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Essential role of immunoglobulin G in the development of arthritis immunized by glucose -6- phosphate isomerase, Annual European Congress of RHEUMATOLOGY2007

    • Author(s)
      Watanabe Y, Matsumoto I, Iwanami K, Inoue A, Mamura M, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Organizer
      EULAR 2007
    • Place of Presentation
      Barcelona
    • Year and Date
      2007-06-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Matsumoto I, Ito S, Sumida T. : Promoter region polymorphism of the tristetraprolin(TTP) gene in patients with rheumatoid arthritis Annual European Congress of RHEUMATOLOGY2007

    • Author(s)
      Suzuki T, Tsutsumi A, Matsui M, Kouno M, Sugihara M, Mamura M, Goto D, Matsumoto I, Ito S, Sumida T.
    • Organizer
      EULAR 2007
    • Place of Presentation
      Barcelona
    • Year and Date
      2007-06-15
    • Related Report
      2008 Final Research Report
  • [Presentation] NKT Cells are Novel Accelerator and Producer of IL-17 in the Pathogenesis of Collagen-induced Arthritis2007

    • Author(s)
      Yoshiga Y., Goto D., Segawa S., Matsumoto I., Ito S., Tsutsumi A., Sumida T.
    • Organizer
      Focis2007
    • Place of Presentation
      San diego
    • Year and Date
      2007-06-09
    • Related Report
      2008 Final Research Report
  • [Presentation] IL-6/T_H-17 axis plays a crucial role in the generation of GPI-induced arthritis2007

    • Author(s)
      Iwanam K., Matsumoto I., Watanabe Y., Inoue A., Mamura M., Goto D., Ito S., Tsutsumi A., Sumida T.
    • Organizer
      Focis2007
    • Place of Presentation
      San diego
    • Year and Date
      2007-06-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression of the Interleukin 17 (IL-17) Gene in Patients with Rheumatoid Arthritis(RA)2007

    • Author(s)
      Kohno M, Tsutsumi A, Sugihara M, Matsui H, Suzuki T, Mamura M, Goto D, Matsumoto I, Ito S, Sumida T.
    • Organizer
      The 2^<nd> East Asian Group of Rheumatology Meeting
    • Place of Presentation
      Korea
    • Year and Date
      2007-05-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Functional Analysis of Autoantibodies to Muscarinic M3 Acetylcholine Receptor in Patients with Sjogren's Syndrome2007

    • Author(s)
      Nakamura Y, Wakamatsu E, Matsumoto I, Mamura M, Goto D, Ito S, Tsutsumi A, Sumida T.
    • Organizer
      The 2nd East Asian Group of Rheumatology Meeting
    • Place of Presentation
      Korea
    • Year and Date
      2007-05-19
    • Related Report
      2008 Final Research Report
  • [Presentation] シェーグレン症候群の分子病態と治療戦略2007

    • Author(s)
      住田孝之
    • Organizer
      第104回日本内科学会講演会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-03
    • Related Report
      2008 Final Research Report
  • [Presentation] シェーグレン症候群の分子病態と治療戦略2007

    • Author(s)
      住田 孝之
    • Organizer
      日本内科学会総会(教育講演)
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Functional gene polymorphisms in rheumatoid arthritis and periodontitis The 93rd2007

    • Author(s)
      Kobayashi T, Ito S, Kuroda T, Yamamoto K, Sugita N, Narita I, Sumida T, Gejyo F, Yoshie H.
    • Organizer
      Annual Meeting of the American Academy of Periodontology
    • Place of Presentation
      Washington DC
    • Related Report
      2008 Final Research Report
  • [Book] シェーグレン症候群とは、やさしいシェーグレン症候群の自己管理2008

    • Author(s)
      住田孝之
    • Publisher
      医薬ジャーナル社(住田孝之)
    • Related Report
      2008 Final Research Report
  • [Book] やさしいシェーグレン症候群の自己管理2008

    • Author(s)
      住田孝之
    • Publisher
      医薬ジャーナル社
    • Related Report
      2008 Annual Research Report
  • [Book] Sjogren症候群,今日の診断基準2007

    • Author(s)
      住田孝之
    • Publisher
      南江堂(大田健、奈良信雄(編集))
    • Related Report
      2008 Final Research Report
  • [Book] Autoantibodies second edition2007

    • Author(s)
      Sumida, T., et. al.
    • Publisher
      Elsevier
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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