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Biochemical and Genetic Analysis of Perimenstrual Asthma Based on Epidermological Survey of Asthma in Niigata

Research Project

Project/Area Number 19591160
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionNiigata University

Principal Investigator

HASEGAWA Takashi  Niigata University, 医歯学総合病院・医科総合診療部, 准教授 (90361906)

Co-Investigator(Kenkyū-buntansha) SUZUKI Eiiti  新潟大学, 医歯学総合病院, 教授 (30187710)
TAKADA Toshinori  新潟大学, 医歯学系, 講師 (40361919)
TOYABE Shinnichi  新潟大学, 危機管理室, 教授 (20227648)
Co-Investigator(Renkei-kenkyūsha) SUZUKI Eiiti  新潟大学, 医歯学総合病院, 教授 (30187710)
TAKADA Toshinori  新潟大学, 医歯学系, 講師 (40361919)
TOYABE Shinnichi  新潟大学, 危機管理室, 教授 (20227648)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords月経喘息 / アスピリン喘息 / 遺伝子多型 / β受容体 / ロイコトリエン受容体1 / ロイコトリエン受容体2 / 遺伝子解析 / アンケート調査 / プロスタグランジン受容体
Research Abstract

本研究は、成人気管支喘息患者とその主治医に対する新潟県内のアンケート調査とそれを行う県内医師ネットワークを基盤として行われた。疫学的解析の結果では、有月経女性喘息585症例中、月経喘息症例は82症例、有月経女性喘息症例(コントロール症例)は503症例であり、月経喘息の24.4%がアスピリン喘息であった。また、有生理女性のアスピリン喘息症例58症例中20症例が月経喘息症例であり、月経喘息に対する重要な関与が示され、また、アスピリン喘息症例との類似性が確認された。新潟大学遺伝子倫理委員会の承認のもとに、対象症例の遺伝子収集が開始され、コントロール症例や非喘息症例を含め現在346症例の検体を得て、ロイコトリエン受容体の遺伝子解析が行われた。今回の検討では、ロイコトリエン受容体1、2の遺伝子多型について、月経喘息症例とコントロール症例間では、有意な違いは認められず、ロイコトリエン受容体変異が月経喘息発症機序に関与する可能性は低い事が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (38 results)

All 2009 2008 2007

All Journal Article (22 results) (of which Peer Reviewed: 16 results) Presentation (16 results)

  • [Journal Article] The impact of the Chuetsu Earthquake on asthma control2009

    • Author(s)
      Suzuki K, Hasegawa T, Iguchi S, Ota K, Sakagami T, Gejyo F, Suzuki E
    • Journal Title

      Allergology International 56

      Pages: 179-179

    • NAID

      10019480468

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of inhaled cortico-steroid selection for each patient with bronchial asthma using questionnaire survey-Effects of age, gender, and disease severity-2009

    • Author(s)
      Ota K, Hasegawa T, Koya T, Sakagami T, Sekikawa T, Toyabe S, Akazawa K, Arakawa M, Gejyo F, Suzuki E
    • Journal Title

      Allergology International (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An Analysis of Factors that Exacerbate Asthma, Based on a Japanese Questionnaire2009

    • Author(s)
      Koyanagi K, Koya T, Sasagawa M, Hasegawa T, Suzuki E, Arakawa M, Gejyo F
    • Journal Title

      Allergology International (in press)

    • NAID

      10027165513

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of inhaled cortico-steroid selection for each patient with bronchial asthma using questionnaire survey.2009

    • Author(s)
      太田球磨, 長谷川隆志, 鳥谷部真一, 鈴木榮一, 他
    • Journal Title

      Allergology International (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Analysis of Factors that Exacerbate Asthma, Based on a Japanese Questionnaire.2009

    • Author(s)
      小柳久美子, 長谷川隆志, 鈴木榮一, 他
    • Journal Title

      Allergology International (in press)

    • NAID

      10027165513

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in lymphocyte profile between BAL fluid and human lung tissue from patients with interstitial lung disease2008

    • Author(s)
      Fujimori F, Shimizu T, Takada T, Narita J, Suzuki E, Gejyo F
    • Journal Title

      Br J Biomed Sci 65

      Pages: 63-67

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高齢者気管支喘息におけるQuality of life の検討2008

    • Author(s)
      真島一郎, 山岸格史, 藤村健夫, 清水夏恵, 江部佑輔, 斎藤功, 村上修一, 片桐敦子, 吉嶺文俊, 長谷川隆志, 村松芳幸,下條文武, 田中裕
    • Journal Title

      日本心療内科学会誌 12

      Pages: 218-223

    • NAID

      10024592340

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] アスリートにおける喘息管理2008

    • Author(s)
      田中純太, 長谷川隆志, 荒川正昭
    • Journal Title

      International Review of Asthma 10

      Pages: 30-38

    • Related Report
      2008 Final Research Report
  • [Journal Article] Differences in lymphocyte profile between BAL fluid and human lung tissue from patients with interstitial lung disease.2008

    • Author(s)
      富士盛文夫, 高田俊範, 鈴木榮一, 他
    • Journal Title

      Br J Biomed Sci 65

      Pages: 63-67

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高齢者気管支喘息におけるQuality of lifeの検討2008

    • Author(s)
      真島一郎, 長谷川隆志, 下条文武, 他
    • Journal Title

      日本心療内科学会誌 12

      Pages: 218-223

    • NAID

      10024592340

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アスリートにおける喘息管理.2008

    • Author(s)
      田中純太, 長谷川隆志, 荒川正昭
    • Journal Title

      International Review of Asthma 10

      Pages: 30-38

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Analysis of perimenstrual asthma based on questionnaire surveys in Japan2007

    • Author(s)
      Suzuki K, Hasegawa T, Sakagami T, KoyaT, Toyabe S, Akazawa K, Arakawa M, Gejyo F, Suzuki E
    • Journal Title

      Allergology International 56

      Pages: 249-255

    • NAID

      10019815548

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population2007

    • Author(s)
      Sakagami T, Jinnai N, Nakajima T, Sekigawa T, Hasegawa T, Suzuki E, Inoue I, Gejyo F
    • Journal Title

      J Hum Genet 52

      Pages: 66-72

    • NAID

      10018515160

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Factors influencing adherence in outpatients using beclomethasone dipropionate inhaler for bronchial asthma2007

    • Author(s)
      Suzuki T, Hasegawa T, Kawada T, Suzuki E, Satoh H, Gejyo F, Sato H, Nishigaki R
    • Journal Title

      Jpn J Pharm Health Care Sci 33

      Pages: 221-228

    • NAID

      110006224465

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asthma ControlTest(ACT)による喘息評価と吸入指導の有用性2007

    • Author(s)
      佐藤英夫, 岩島明, 宇野友康, 片野寛子,旅河佐知子, 鈴木知信, 遠藤弘, 下條文武,長谷川隆志, 鈴木栄一
    • Journal Title

      Pharma Medica 25

      Pages: 161-165

    • Related Report
      2008 Final Research Report
  • [Journal Article] 吸入ステロイドの展望2007

    • Author(s)
      長谷川隆志
    • Journal Title

      導入のコツ吸入療法指導の手びきProgress in Medicine 27

      Pages: 1324-1328

    • Related Report
      2008 Final Research Report
  • [Journal Article] Analysis of perimenstrual asthma based on questionnarie surveys in Japan.2007

    • Author(s)
      鈴木和夫, 長谷川隆志, 鳥谷部真一, 鈴木栄一, 他
    • Journal Title

      Allergology International 56

      Pages: 249-255

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors influencing adherence in outpatients using beclomethasone dipro pionate inhaler for bronchial asthma.2007

    • Author(s)
      鈴木知子, 長谷川隆志, 鈴木栄一, 他
    • Journal Title

      Jpn J Pharm Health Care Sci. 33

      Pages: 221-228

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population.2007

    • Author(s)
      坂上拓郎, 長谷川隆志, 鈴木栄一, 他
    • Journal Title

      J Hum Genet. 52

      Pages: 66-72

    • NAID

      10018515160

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of the Chuetsu Earthquake on asthma control.2007

    • Author(s)
      鈴木和夫, 長谷川隆志, 鈴木栄一, 他
    • Journal Title

      Allergology International 56

      Pages: 179-179

    • NAID

      10019480468

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asthma Control Test (ACT)による喘息評価と吸入指導の有用性2007

    • Author(s)
      佐藤英夫, 長谷川隆志, 鈴木栄一, 他
    • Journal Title

      Pharma Medica 25

      Pages: 161-165

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 【吸入ステロイドの展望】導入のコツ 吸入療法指導の手びき2007

    • Author(s)
      長谷川隆志
    • Journal Title

      Progress in Medicine 27

      Pages: 1324-1328

    • Related Report
      2007 Annual Research Report
  • [Presentation] Worsening of Asthma Symptom Control in Japan Based on Analysis of Questionnaire Surveys of More Than 20,000 Cases from 1998 to 20062008

    • Author(s)
      Koya T, Hasegawa T, Arakawa M, Gejyo F, Suzuki E
    • Organizer
      2008 ATS International Conference
    • Place of Presentation
      Toronto
    • Year and Date
      2008-05-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Importance of Aspirin Intolerant Asthma for Near Fatal Asthma and Alteration of Incidence Based on Questionnaire Surveys in Japan2008

    • Author(s)
      Yoshimine F, Hasegawa T, Koya T, Arakawa M, Gejyo M, Suzuki E
    • Organizer
      2008 ATS International Conference
    • Place of Presentation
      Toronto
    • Year and Date
      2008-05-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Worsening of Asthma Symptom Control in Japan Based on Analysis of Questionnaire Surveys of More Than 20, 000 Cases from 1998 to 2006.2008

    • Author(s)
      小屋俊之, 長谷川隆志, 鈴木榮一, 他
    • Organizer
      ATS, International Conference
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Importance of Aspirin Intolerant Asthma for Near Fatal Asthma and Alteration of Incidence Based on Questionnaire Surveys in Japan.2008

    • Author(s)
      吉嶺文俊, 長谷川隆志, 鈴木榮一, 他
    • Organizer
      ATS, International Conference
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects on Serum IgE Level Based on Questionnaire Surveys in Japan-Independent on Disease Severity-2008

    • Author(s)
      Kobayashi Y, Hasegawa T, Koya T, Sasagawa M, Arakawa M, Gejyo F, Suzuki E
    • Organizer
      2008 ATS International Conference
    • Place of Presentation
      Toronto
    • Year and Date
      2008-05-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects on Serum IgE Level Based on Questionnaire Surveys in Japan-Independent on Disease Severity-.2008

    • Author(s)
      小林義昭, 長谷川隆志, 鈴木榮一, 他
    • Organizer
      ATS, International Conference
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-05-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新潟県多施設アンケート調査からの月経喘息についての検討2004 年と2006 年の比較2007

    • Author(s)
      鈴木和夫, 小屋俊之, 下條文武, 荒川正昭, 長谷川隆志, 鈴木栄一
    • Organizer
      平成19年度日本アレルギー学会秋季学術集会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2007-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 新潟県多施設アンケート調査からの月経喘息についての検討 2004年と2006年の比較2007

    • Author(s)
      鈴木和夫, 長谷川隆志, 鈴木栄一, 他
    • Organizer
      第57回日本アレルギー学会秋期学術大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of age, gender and disease severity on the use of inhaled corticosteroid in Japan2007

    • Author(s)
      Oota K, Hasegawa T, Suzuki E, Sakagami T, Koya T, Arakawa M, Gejyo F
    • Organizer
      2007 ATS International Conference
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-05-21
    • Related Report
      2008 Final Research Report
  • [Presentation] The Ile198Thy and Ala379Val Polymorphisms of Platelet-Activating Factor-Acethyl hayd-orase Polymorphisms Are Associated withAsthma, Asthma Severity and Rate of Lung Function Decline in Japanese Population2007

    • Author(s)
      Sakagami T, Sekikawa T, Hasegawa T, Takada T, Suzuki E, Gejyo F, Inoue I
    • Organizer
      2007 ATS International Conference
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-05-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis of pulmonary function in athletes from the aspect of bronchial asthma2007

    • Author(s)
      Tanaka J, Hasegawa T, Arakawa M, Hashiba M, Sakagami T, Koya T, Gejyo F, Suzuki E
    • Organizer
      2007ATS International Conference
    • Place of Presentation
      Francisco
    • Year and Date
      2007-05-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of age, gender and disease severity on the use of inhaled cortico-steroid in Japan.2007

    • Author(s)
      太田求磨, 長谷川隆志, 鈴木栄一, 他
    • Organizer
      ATS, International Conference
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-05-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Ile198Thy and Ala379Val Polymorphisms of Platelet-Activationg Factor-Acethylhaydorase Polymoiphisms Are Associated with Asthma, Asthma Severity and Rate of Lung Function Decline in Japanese Population.2007

    • Author(s)
      坂上拓郎, 長谷川隆志, 鈴木栄一, 他
    • Organizer
      ATS, International Conference
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-05-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Analysis of screening pulmonary function test in athletes from the aspect of bronchial asthma.2007

    • Author(s)
      田中純太, 長谷川隆志, 鈴木栄一, 他
    • Organizer
      ATS, International Conference
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-05-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Inhaled Corticosteroid Does Not Affect Bone Mineral Density in Japanese Asthmatic Patients : Half A Year Treatment Study2007

    • Author(s)
      Sasagawa M, Hasegawa T, Fujimori K, Yoshimine F, Sato K, Hara K, Suzuki K, Sakagami T, Koya(3), Kazama JJ, Gejyo F, Suzuki E
    • Organizer
      2007 ATS International Conference
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-05-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Inhaled Corticosteroid Does Not Affect Bone Mineral Density in Japanese Asthmatic Patients: Half A Year Treatment Study.2007

    • Author(s)
      篠川真由美, 長谷川隆志, 鈴木栄一, 他
    • Organizer
      ATS, International Conference
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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