Regulation of cell growth and cytokine production in basophils

• Project/Area Number: 19591162
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Shinshu University
• Principal Investigator: HIDA Shigeaki Shinshu University, 医学系研究科, 助教 (10345762)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: サイトカイン / シグナル伝達 / 好塩基球 / Th2 / インターロイキン / FcRγ / IRF / インターロイキン3 / インターロイキン4 / IRF-2

Research Abstract

近年、アレルギー反応やアレルゲンに反応する初期免疫応答における好塩基球の役割がマウスモデルで明らかになりつつあるが、好塩基球の活性化における分子機構に関して不明な点が多い。本研究課題では、これまでの好塩基球依存的な免疫制御についての成果から、好塩基球のサイトカイン産生機構や細胞増殖の分子機構について解析し、FcRγ分子を介した新規のシグナル伝達経路を同定した。

Research Products

• [Journal Article] Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils (2009)
  • Author(s): Hida, S, Yamasaki, S, Sakamoto, Y, Takamoto, M, Obata, K, Takai, T, Karasuyama, H, Sugane, K, Saito, T, and Taki, S
  • Journal Title: Nature mmunol 10 Pages: 214-222
  • URL: http://www.nature.com/ni/journal/v10/n2/abs/ni.1686.html
  • Peer Reviewed
• [Journal Article] Fc receptor γ-chain. a constitutive component, of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. (2009)
  • Author(s): Hida Shigeaki
  • Journal Title: Nature Immunology 10 Pages: 214-222
  • Peer Reviewed
• [Journal Article] IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1+B220+ NK cells (2008)
  • Author(s): Nakajima, S, Hida, S, and Taki, S,
  • Journal Title: Biochem. Biophys. Res. Commun 369 Pages: 1139-1143
  • URL: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4S1JHR9-7&_user=4307883&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050561&_version=1&_urlVersion=0&_userid=4307883&md5=96abb319aded6003c3c9719e7c5a971e
  • Peer Reviewed
• [Journal Article] 好塩基球を介するTh2細胞の誘導 (2008)
  • Author(s): 肥田重明、瀧伸介
  • Journal Title: 分子細胞治療 7 Pages: 149-155
• [Journal Article] IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1+B220+ NK cells. (2008)
  • Author(s): Nakajima Shinsuke
  • Journal Title: Biochem. Biophys. Res. Commun. 396 Pages: 1139-1143
  • Peer Reviewed
• [Journal Article] 好塩基球を介するTh2細胞の誘導 (2008)
  • Author(s): 肥田重明
  • Journal Title: 分子細胞治療 7 Pages: 149-155
• [Journal Article] Genetic control directed towards spontaneous IFN-α/β responses and downstream IFN-γ expression influences the pathogenesis ofa murine psoriasis-like skin disease. (2007)
  • Author(s): Arakura, F., Hida, S., et. al.
  • Journal Title: The Journal of Immunology 179 Pages: 3249-3257
  • Peer Reviewed
• [Presentation] The role of IFN-γ and IL-17 on Pneumocystis pneumonia in nude mice (2008)
  • Author(s): Hu Tao, Takamoto M, Hida S, Sugane K,
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] The role of IFN-γ and IL-17 on Pneumocystis pneumonia in nude mice. (2008)
  • Author(s): Hu Tao
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2008-12-01
• [Presentation] Fc receptor γ-chain is a subunit of IL-3 receptor complexes, requiredfor IL-4 expression by but not proliferation of murine basophils (2007)
  • Author(s): Hida S, Yamasaki S, Saito T, Taki S,
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Paired immunoglobulin-like receptor(PIR)-B regulates IL-3 responces in basophils (2007)
  • Author(s): Kikuchi H, Sakamoto Y, Takai T, Hida S, Taki S
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Fc receptor γ-chain is a subunit of IL-3 receptor complexes, required for IL-4 expression by but not proliferation of murine basophils (2007)
  • Author(s): 肥田 重明
  • Organizer: 第37回 日本免疫学会総合
  • Place of Presentation: グランドプリンスホテル新高輸
  • Year and Date: 2007-11-21
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/zouki/immunol/main_frame.htm
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/zouki/immunol/main_frame.htm
• [Remarks]
  • URL: http://dept.md.shinshu-u.ac.jp/immunol/main_frame.htm