• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the immunoregulation through GPCR expressing in immunocompetent cells and therapy for the autoimmune diseases

Research Project

Project/Area Number 19591168
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionEhime University

Principal Investigator

HASEGAWA Hitoshi  Ehime University, 大学院・医学系研究科, 准教授 (40164826)

Co-Investigator(Kenkyū-buntansha) 井上 淳  愛媛大学, 大学院・医学系研究科, 講師 (20403826)
Co-Investigator(Renkei-kenkyūsha) INOUE Atsushi  愛媛大学, 大学院・医学系研究科, 講師 (20403826)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsG-protein coupled receptors / chemokines / regulatory T cells / Th1 cells / Th2 cells / lipids / Chemokines
Research Abstract

ヒト制御性T細胞、Th1およびTh2細胞に発現するG蛋白共役型受容体(GPCR)を網羅的に解析し、それぞれの細胞に特異的に発現するGPCRを単離した。また、多くのGPCRのリガンドが含まれる脂質ライブラリー等からも、制御性T細胞の機能を変化させる物質を単離した。これらのうち、LysophosphatidylcholineやPPARアゴニストは、ヒト制御性T細胞の抑制機能を高めた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (13 results)

All 2009 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (8 results)

  • [Journal Article] Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model2008

    • Author(s)
      Hasegawa H, Inoue A, Kohno M, Lei J, Miyazaki T, Yoshie O, Nose M, Yasukawa M
    • Journal Title

      Gene Therapy 15

      Pages: 171-182

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine blockade for lupus model mice2008

    • Author(s)
      Hasegawa H
    • Journal Title

      Front. Biosci 13

      Pages: 2900-2908

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model.2008

    • Author(s)
      Hasegawa H, et al.
    • Journal Title

      Gene Therapy 15

      Pages: 171-182

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine blockade for lupus model mice.2008

    • Author(s)
      Hasegawa H
    • Journal Title

      Front. Biosci. 13

      Pages: 2900-2908

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model2008

    • Author(s)
      Hasegawa H, et. al.
    • Journal Title

      Gene Therapy 15

      Pages: 171-182

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒト制御性T細胞への分化誘導を促進する生理活性物質の解析2009

    • Author(s)
      金磊、長谷川均、河野政志、井上淳、安川正貴
    • Organizer
      第53回日本リウマチ学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-25
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] ヒトCD4陽性Tリンパ球のFoxp3の発現を増強する脂質および核内受容体リガンドの解析2008

    • Author(s)
      長谷川均、金磊、河野政志、井上淳、安川正貴
    • Organizer
      第38回日本免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 「血管炎研究の最前線」血管炎・腎炎とケモカイン : 治療への応用2008

    • Author(s)
      長谷川均
    • Organizer
      第54回日本病理学会秋期特別総会
    • Place of Presentation
      松山
    • Year and Date
      2008-11-20
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] ケモカインレセプター発現制御性T細胞を用いた自己免疫疾患およびGVHDの治療2008

    • Author(s)
      長谷川均、井上淳、河野政志、能勢眞人、安川正貴
    • Organizer
      第52回日本リウマチ学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-04-21
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Therapeutic effect of CXCR3-expressing regulatory T cells on liver and intestinal damages in a murine acute GVHD model.2007

    • Author(s)
      Yamanouchi J, Hasegawa H, Inoue A, Kohno M, Fujiwara H, Hato T, Yasukawa M
    • Organizer
      49^<th> American Society of Hematology
    • Place of Presentation
      Atlanta, Georgia, USA.
    • Year and Date
      2007-12-09
    • Related Report
      2008 Final Research Report
  • [Presentation] GVHDモデルマウスの肝および腸管傷害に対するCXCR3強制発現制御性T細胞の抑制効果2007

    • Author(s)
      井上 淳、長谷川 均, 他
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] GVHDモデルマウスの肝および腸管傷害に対するCXCR3強制発現制御性T細胞の抑制効果2007

    • Author(s)
      井上淳、長谷川均、河野政志、金磊、宮崎龍彦、能勢眞人、安川正貴
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] MRL/lprマウスの臓器傷害に対するCCR2強制発現制御性T細胞の抑制効果2007

    • Author(s)
      長谷川均、河野政志、井上淳、金磊、宮崎龍彦、能勢眞人、安川正貴
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi