c-Cbl-interacting protein of 85 kDa (CIN85) regulates the function of normal and autoimmune B cells
| Project/Area Number |
19591169
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
|
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| Research Institution | Kyushu University |
|---|
Principal Investigator |
NIIRO Hiroaki Kyushu University, 大学病院, 助教 (20380636)
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| Co-Investigator(Kenkyū-buntansha) |
AKASHI Koichi 九州大学, 大学院医学研究院, 教授 (80380385)
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| Project Period (FY) |
2007 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 自己免疫疾患 / 細胞・組織 / 免疫学 / シグナル伝達 / 内科 |
|---|
| Research Abstract |
B細胞抗原受容体(BCR)下流の正負シグナルのバランス調節は、自己反応性B細胞を自己寛容あるいは自己免疫の方向へ誘導するかの運命決定の上で重要である。本研究では、c-Cbl 会合アダプター(CIN85)がBCR下流においてこのようなシグナルバランス調整に重要な分子であることが明らかになった。
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Human Flt3 Is Expressed at the Hematopoietic Stem Cell and the Granulocyte/Macrophage Progenitor Stages to Maintain Cell Survival2008
Author(s)
Kikushige Y, Yoshimoto G, Miyamoto T, Iino T, Mori Y, Iwasaki H, Niiro H, Takenaka K, Nagafuji K, Harada M, Ishikawa F, Akashi K
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Journal Title
J. Immunol 180(11)
Pages: 7358-7367
Related Report
Peer Reviewed
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[Journal Article] Biliary epithelial cells and primary biliary cirrhosis : the role of liverinfiltrating mononuclear cells2008
Author(s)
Shimoda S, Harada K, Niiro H, Yoshizumi T, Soejima Y, Taketomi A, Maehara Y, Tsuneyama K, Nakamura M, Komori A, Migita K, Nakanuma Y, Ishibashi H, Selmi C, Gershwin ME
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Journal Title
Hepatology 47(3)
Pages: 958-965
Related Report
Peer Reviewed
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[Journal Article] The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways2007
Author(s)
Ishikawa F, Niiro H, Iino T, Yoshida S, Saito N, Onohara S, Miyamoto T, Minagawa H, Fujii SI, Shultz LD, Harada M, Akashi K
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Journal Title
Blood 110(10)
Pages: 3591-3600
Related Report
Peer Reviewed
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[Journal Article] Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis2007
Author(s)
Kawano A, Shimoda S, Kamihira T, Ishikawa F, Niiro H, Soejima Y, Taketomi A, Maehara Y, Nakamura M, Komori A, Migita K,Ishibashi H, Azuma M, Gershwin ME, Harada M
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Journal Title
J. Immunol 179(5)
Pages: 3315-3324
Related Report
Peer Reviewed
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