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FOXP3 isoform expression in the regulatory T cells in systemic lupus erythematosus patients and its role in the mechanism of the immue suppression

Research Project

Project/Area Number 19591177
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionSaitama Medical University

Principal Investigator

SUZUKI Katsuya  Saitama Medical University, 医学部, 助教 (70306695)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Tsutomu  埼玉医科大学, 医学部, 教授 (50179610)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords全身性エリテマトーデス / T細胞 / 制御性T細胞 / FOXP3 / アイソフォーム免疫寛容 / アイソフォーム / 免疫寛容
Research Abstract

In patient with systemic lupus erythematosus (SLE), gene expression of both FOXP3 and its isoform, which express in regulatory T cell (Treg) that play an important role in immune tolerance, were decreased. These results indicated that both are important as a cause in immune tolerance in SLE. Next we investigated FOXP3 expression in immune suppressive state and found that decreased Treg subpopulation was not natural but induced Treg. From our study, we obtained important clues on the effective therapeutic target for SLE.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (31 results)

All 2010 2009 2008 2007

All Journal Article (13 results) (of which Peer Reviewed: 8 results) Presentation (18 results)

  • [Journal Article] IgG4-related systemic disease manifesting as Mikulicz disease with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation2010

    • Author(s)
      Suzuki K, Tamaru J, Okuyama A, Kameda H, Amano K, Nagasawa H, Nish E, Yoshimoto K, Setoyama Y, Kaneko K, Osada H, Honda N, Sasaki Y, Itoyama S, Tsuzaka K, Takeuchi T
    • Journal Title

      Rheumatology (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新薬展望2010抗リウマチ薬2010

    • Author(s)
      鈴木勝也, 竹内勤
    • Journal Title

      医薬ジャーナル増刊号(医薬ジャーナル社) Vol.46S-1

      Pages: 217-21

    • Related Report
      2009 Final Research Report
  • [Journal Article] Single Center Prospective Study of Tacrolimus Efficacy and Safety in Treatment of Various Manifestations in Systemic Lupus Erythematosus2010

    • Author(s)
      Suzuki K, Kameda H, Amano K, Nagasawa H, Takei H, Nishi E, Okuyama A, Tsuzaka K, Takeuchi T
    • Journal Title

      Rheumatology int

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] IgG4-related systemic disease manifesting as Mikulicz disease with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation2010

    • Author(s)
      鈴木勝也
    • Journal Title

      Rheumatology(Oxford) (ePub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single Center Prospective Study of Tacrolimus Efficacy and Safety in Treatment of Various Manifestations in Systemic Lupus Erythematosus2010

    • Author(s)
      鈴木勝也
    • Journal Title

      Rheumatology Int. (ePub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新薬展望2010抗リウマチ薬2010

    • Author(s)
      鈴木勝也, 竹内勤
    • Journal Title

      医薬ジャーナル増刊号(医薬ジャーナル社) 46S-1

      Pages: 217-21

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Severe acute thrombotic exacerbation in two cases with anti-phospholipid syndrome after retreatment with rituximab in phase I/II clinical trial for refractory systemic lupus erythematosus2009

    • Author(s)
      Suzuki K, Nagasawa H, Kameda H, Amano K, Kondo T, Itoyama S, Tanaka Y, Takeuchi T
    • Journal Title

      Rheumatology 48(2)

      Pages: 198-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single Center Prospective Study of Tacrolimus Efficacy and Safety in Treatment of Rheumatoid Arthritis2009

    • Author(s)
      Suzuki K, Kameda H, Amano K, Nagasawa H, Takei H, Sekiguchi N, Nishi E, Ogawa H, Tsuzaka K, Takeuchi T
    • Journal Title

      Rheum. Int 29(4)

      Pages: 431-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特集臨床でわかったエビデンスType 1インターフェロンはループスだけの特徴か2009

    • Author(s)
      鈴木勝也, 竹内勤
    • Journal Title

      分子リウマチ治療 vol.2,No.3

      Pages: 119-22

    • Related Report
      2009 Final Research Report
  • [Journal Article] Severe acute thrombotic exacerbation in two cases with anti-phospholipid syndrome after retreatment with rituximab in phase I/II clinical trial for refractory systemic lupus erythematosus2009

    • Author(s)
      鈴木勝也
    • Journal Title

      Rheumatology(Oxford) 48(2)

      Pages: 198-9

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Interleukin 2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF) in human peripheral blood mononuclear cells2008

    • Author(s)
      Suzuki K, Setoyama Y, Yoshimoto K, Tsuzaka K, Abe T, Takeuchi T
    • Journal Title

      Cytokine 44(1)

      Pages: 44-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特集リウマチ性疾患における腎障害ループス腎炎に対するタクロリムスの有用性2008

    • Author(s)
      鈴木勝也, 竹内勤
    • Journal Title

      リウマチ科 40(6)

      Pages: 604-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] 話題クラスター分類の最新の情報2007

    • Author(s)
      鈴木勝也, 瀬戸山由美子, 竹内勤
    • Journal Title

      臨床検査 51(9)

      Pages: 983-5

    • Related Report
      2009 Final Research Report
  • [Presentation] T細胞に対するイムノロジカルインターベンション2009

    • Author(s)
      鈴木勝也
    • Organizer
      第5回リウマチヤングアカデミー
    • Place of Presentation
      北広島
    • Year and Date
      2009-07-18
    • Related Report
      2009 Final Research Report
  • [Presentation] T細胞に対するイムノロジカ ルインターベンション2009

    • Author(s)
      鈴木勝也
    • Organizer
      第5回リウマチヤン グアカデミー
    • Place of Presentation
      北広島(北海道)
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] ループス腎炎に対するタクロリムスの有用性2009

    • Author(s)
      鈴木勝也
    • Organizer
      第3回埼玉リウマチ・膠原病フォーラム
    • Place of Presentation
      さいたま
    • Year and Date
      2009-07-04
    • Related Report
      2009 Final Research Report
  • [Presentation] ループス腎炎に対するタクロ リムスの有用性2009

    • Author(s)
      鈴木勝也
    • Organizer
      第3回埼玉リウマチ・膠原病フォーラム
    • Place of Presentation
      さいたま(埼玉)
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Immunological intervention for systemic lupus erythematosus, Seminar2009

    • Author(s)
      Suzuki K
    • Organizer
      NIH Science Event
    • Place of Presentation
      Bethesda, MD, USA(Invited)
    • Year and Date
      2009-06-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Immunological intervention for systemic lupus erythematosus2009

    • Author(s)
      鈴木勝也
    • Organizer
      NIH Science Event(Invited Seminar)
    • Place of Presentation
      ベセスダ(米国)
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of B cell activating factor belonging to the tumor necrosis factor family (BAFF) Synthesis by Interleukin-2 in human peripheral blood mononuclear cells2008

    • Author(s)
      鈴木勝也
    • Organizer
      第38回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Tacrolimus has Pleiotropic Molecular Effects on Human Regulatory T Cells, American College of Rheumatology2008

    • Author(s)
      Suzuki K
    • Organizer
      72st annual scientific meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-10-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 全身性エリテマトーデスおよび関節リウマチにおける末梢制御性T細胞の役割2008

    • Author(s)
      鈴木勝也
    • Organizer
      第36回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-18
    • Related Report
      2009 Final Research Report
  • [Presentation] 膠原病におけるタクロリムスの有用性2008

    • Author(s)
      鈴木勝也
    • Organizer
      第2回埼玉リウマチ・膠原病フォーラム
    • Place of Presentation
      浦和
    • Year and Date
      2008-06-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチ患者末梢制御性T細胞の量的質的異常と治療薬の与える影響2008

    • Author(s)
      鈴木勝也
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2008-04-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Molecular Effects to Human Regulatory T cells by Treatment with T Cell Activation Inhibitor and TNF Blockade2008

    • Author(s)
      Suzuki K
    • Organizer
      The American Association of Immunologist 95th annual meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-04-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Molecular Effects to Human Regulatory T cells by Treatment with T Cell Activation Inhibitor and TNF Blockade2008

    • Author(s)
      Suzuki K
    • Organizer
      The American Association of Immunologist 95^<th> annual meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-04-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulatory T cells and FOXP3 isoform expression in patients with systemic lupus erythematosus and rheumatoid arthritis2007

    • Author(s)
      鈴木勝也
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Reguratory T cells and FOXP3 isoform expression in patients with systemic lupus erythematosus and rheumatoid arthritis2007

    • Author(s)
      Suzuki K, Setoyama Y, Suzuki M, Yoshimoto K, Kameda H, Tsuzaka K, Amano K, Takeuchi T
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] T細胞活性化阻害薬およびTNF阻害薬の末梢制御性T細胞に対する影響2007

    • Author(s)
      鈴木勝也
    • Organizer
      第35回日本臨床免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-19
    • Related Report
      2009 Final Research Report
  • [Presentation] リウマチ性疾患に対するタクロリムス治療の安全性と有効性2007

    • Author(s)
      鈴木勝也
    • Organizer
      第51回日本リウマチ学会総会・学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-04-27
    • Related Report
      2009 Final Research Report
  • [Presentation] Efficasy and safety of tacrolimus in patients with rheumatic disease: appropriate clinical application for various rheumatic conditions2007

    • Author(s)
      Suzuki K
    • Organizer
      American College of Rheumatology 71st annual scientific meeting
    • Place of Presentation
      Boston, USA
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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