Transcription factors regulating allergy-related gene expression

• Project/Area Number: 19591179
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Juntendo University
• Principal Investigator: NISHIYAMA Chiharu Juntendo University, 医学研究科, 准教授 (20327836)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: アレルギー学 / 遺伝子 / 転写調節因子 / マスト細胞 / IgE / FcεRI / アレルギー / 一塩基置換多型 / PU.1 / 樹状細胞

Research Abstract

免疫担当細胞、特にマスト細胞や樹状細胞を標的に転写調節因子の機能調節により、細胞の機能変化を誘導し、アレルギー疾患、自己免疫疾患モデルにおいて改善効果を示すことが確認され、新たな治療法を提案した。また、IgE受容体α鎖遺伝子多型が転写調節因子の結合および活性に影響を及ぼす結果エフェクター細胞上の受容体発現量を左右する作用を持つことが明らかとなったが、同多型がごく最近欧州におけるゲノムワイドスクリーニングにおいてアトピー関連多型であることが報告されたことから、民族を超えて支持された多型の機能を世界に先駆けて報告するに至った。

Research Products

• [Journal Article] Human umbilical cord epithelial cells express Notch ligands Delta1 and Jagged1 (2009)
  • Author(s): Ng, W., Nishiyama, C., Mizoguchi, M., Ikeda, S., Okumura, K., Ogawa, H.
  • Journal Title: J. Dermatol. Sci 54 Pages: 131-134
  • NAID: 10025333577
  • Peer Reviewed
• [Journal Article] Functional analysis of a polymorphism in the promoter region of the IL-12/23p40 gene (2009)
  • Author(s): Shimokawa, N., Nishiyama, C., Hirota, T., Tamari, M., Hara, M., Ikeada, S., Okumura, K., Ogawa, H.
  • Journal Title: Clin. Exp. Allergy 39 Pages: 228-235
  • Peer Reviewed
• [Journal Article] Notch signaling confers antigen-presenting cell functions on mast cells (2009)
  • Author(s): Nakano, N., Nishiyama, C., Yagita, H., Koyanagi, A., Akiba, H., Chiba, S., Ogawa, H., Okumura, K.
  • Journal Title: J. Allergy Clin. Immunol 123 Pages: 74-81
  • Peer Reviewed
• [Journal Article] Human umbilical cord epithelial cells express Notch ligands Deltal and Jaggedl. (2009)
  • Author(s): William Ng
  • Journal Title: J. Dermatol. Sci. 54 Pages: 131-134
  • Peer Reviewed
• [Journal Article] Functional analysis of a polymorphism in the promoter region of the IL-12/23p40 gene. (2009)
  • Author(s): Naomi Shimokawa
  • Journal Title: Clin. Exp. Allergy 39 Pages: 228-235
  • Peer Reviewed
• [Journal Article] Notch signaling confers antigen-presenting cell functions on mast cells. (2009)
  • Author(s): Nobuhiro Nakano
  • Journal Title: J. Allergy C ; in. Immunol. 123 Pages: 74-81
  • Peer Reviewed
• [Journal Article] Fusion of One twenty-two to BSAC results in aberrant upregulation of transcriptional activity (2008)
  • Author(s): Sawada, T., Nishiyama, C., Kishi, T., Sasazuki, T., Komazawa-Sakon, S., Xue, X., Piao, J.-H., Ogata, H., Nakayama, J.-i., Taki, T., Hayashi, Y., Watanabe, M., Yagita, H., Okumura, K., Nakano, H.
  • Journal Title: J. Biol. Chem 283 Pages: 26820-26828
  • Peer Reviewed
• [Journal Article] Opposite effects of PU.1 on mast cell stimulation (2008)
  • Author(s): Niwa, Y., Nishiyama, C., Nakano, N., Kamei, A., Kato, H., Kanada, S., Ikeda, S., Ogawa, H., Okumura, K.
  • Journal Title: Biochem. Biophys. Res. Commun 375 Pages: 95-100
  • Peer Reviewed
• [Journal Article] FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians (2008)
  • Author(s): Potaczek, D., Sanak, M., Nishiyama, C., Okumura, K., Ogawa, H., Szkzeklik, A.
  • Journal Title: Int. J. Immunogenetics 35 Pages: 339-340
  • Peer Reviewed
• [Journal Article] Suppressive effect of Elf-1 on FcεRIα-chain expression in primary mast cells (2008)
  • Author(s): Wang, Q.-h., Nishiyama, C., Nakano, N., Shimokawa, N., Hara, M., Kanada, S., Ogawa, H., Okumura, K.
  • Journal Title: Immunogenetics 60 Pages: 557-563
  • Peer Reviewed
• [Journal Article] Two different transcription factors discriminate the -315C>T-polymorphism of the FcεRIα gene (2008)
  • Author(s): Kanada, S., Nakano, N., Potaczek, D., Maeda, K., Shimokawa, N., Niwa, Y., Fukai, T., Sanak, M., Szczeklik, A., Yagita, H., Okumura, K., Ogawa, H., Nishiyama, C.
  • Journal Title: J. Immunol 180 Pages: 8204-8210
  • Peer Reviewed
• [Journal Article] Procyanidin C1 from apple extracts inhibits FcεRI-mediated mast cell activation (2008)
  • Author(s): Nakano, N., Nishiyama, C., Tokura, T., Nagasako-Akazome, Y., Ohtake, Y., Okumura, K., Ogawa, H.
  • Journal Title: Int. Arch. Allergy Immunol 147 Pages: 213-221
  • Peer Reviewed
• [Journal Article] FCER1A gene exon 1A polymorphisms in Japanese and Polish subjects (2008)
  • Author(s): Potaczek, D., Nishiyama, C., Sanak, M., Szczeklik, A., Okumura, K., Ogawa, H.
  • Journal Title: Allergy 63 Pages: 626-627
  • Peer Reviewed
• [Journal Article] Human umbilical cord epithelial cells express Notch1 (2008)
  • Author(s): Ng, W., Nishiyama, C., Mizoguchi, M., Nakano, N., Suga, Y., Ikeda, S., Itoh, S., Kinoshita, K., Okumura, K., Ogawa, H.
  • Journal Title: J. Dermatol. Sci 49 Pages: 143-152
  • Peer Reviewed
• [Journal Article] Role of Sp1 in transcription of human ATP2A2 gene promoter in keratinocytes (2008)
  • Author(s): Takagi, A., Nishiyama, C., Maeda, K., Tokura, T., Kawada, H., Kanada, S., Niwa, Y., Nakano, N., Mayuzumi, N., Nishiyama, M., Ikeda, S., Okumura, K., Ogawa, H.
  • Journal Title: J. Invest. Dermatol 128 Pages: 96-103
  • Peer Reviewed
• [Journal Article] Fusion of One twenty-two to BSAC results in aberrant upregulation of transcriptional activity. (2008)
  • Author(s): T. Sawada
  • Journal Title: T. Biol. Chem. 283 Pages: 26820-8
  • Peer Reviewed
• [Journal Article] Opposite effects of PU. I on mast cell stimulation. (2008)
  • Author(s): Yusuke Niwa
  • Journal Title: Biochem. Biophys. Res. Commun. 375 Pages: 95-100
  • Peer Reviewed
• [Journal Article] FCERIA gene proximal promoter polymorphisms in Caucasians and East Asians. (2008)
  • Author(s): Daniel Potaczek
  • Journal Title: Int. J. Immunogenetics 35 Pages: 339-340
  • Peer Reviewed
• [Journal Article] Suppressive effect of Elf-1 on FcεRI α-chain expression in primary mast cells. (2008)
  • Author(s): Q. -h. Wang
  • Journal Title: Immunogenetics 60 Pages: 557-563
  • Peer Reviewed
• [Journal Article] Two different transcription factors discriminate the -315C>T-polymorphism of the FcεRIα gene. (2008)
  • Author(s): Shunsuke Kanada
  • Journal Title: J. Immunol. 180 Pages: 8204-10
  • Peer Reviewed
• [Journal Article] Procyanidin C1 from apple extracts inhibits FcεRI-mediate mast cell activation. (2008)
  • Author(s): Nobuhiro Nakano
  • Journal Title: Int. Arch. Allergy Immunol. 147 Pages: 213-221
  • Peer Reviewed
• [Journal Article] FCER1A gene exon 1A polymorphisms in Japanese and Polish sub jects - a comparative analysis of haplotypes. (2008)
  • Author(s): Daniel Potaczek
  • Journal Title: Allergy 63 Pages: 626-627
  • Peer Reviewed
• [Journal Article] Human umbilical cord epithelial cells express Notchl (2008)
  • Author(s): William Ng
  • Journal Title: J. Dermatol. Sci. 49 Pages: 143-152
  • Peer Reviewed
• [Journal Article] Role of Sp1 in transcription of human ATP2A2 gene promoter in keratinocytes. (2008)
  • Author(s): Atsushi Takagi
  • Journal Title: J. Invest. Dermatol. 128 Pages: 96-103
  • Peer Reviewed
• [Journal Article] Procyanidin C1 from apple extracts inhibits FcεRI-mediate mast cell activation (2008)
  • Author(s): Nobuhiro Nakano
  • Journal Title: Int.Arch.Allergy Immunol
  • Peer Reviewed
• [Journal Article] FCER1A gene exon 1A polymorphisms in Japanese and Polishsubjects-a comparative analysis of haplotypes (2008)
  • Author(s): Daniel P. Potaczek
  • Journal Title: Allergy
  • Peer Reviewed
• [Journal Article] Human umbilical cord epithelial cells express Notch1:Implication for its epidermal-like differentiation (2008)
  • Author(s): Willam Ng
  • Journal Title: J.Dermatol.Sci 49 Pages: 143-152
  • Peer Reviewed
• [Journal Article] Role of Sp1 in transcription of human ATP2A2 gene promoter in keratinocytes (2008)
  • Author(s): Atsushi Takagi
  • Journal Title: J.Invest.Dermatol 128 Pages: 96-103
  • Peer Reviewed
• [Journal Article] Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections (2007)
  • Author(s): Nakano, N., Nishiyama, C., Kanada, S., Niwa, Y., Shimokawa, N., Ushio, H., Nishiyama, M., Okumura, K., Ogawa, H.
  • Journal Title: Blood 109 Pages: 4846-4855
  • Peer Reviewed
• [Journal Article] Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections (2007)
  • Author(s): Nobuhiro Nakano
  • Journal Title: Blood 109 Pages: 4846-4855
  • Peer Reviewed
• [Journal Article] Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus
  • Author(s): Horie, A., Tomita, T., Saiki, A., Kono, H., Taka, H., Mineki, R., Fujimura, T., Nishiyama, C., Kuzuyama, T., Nishiyama, M.
  • Journal Title: Nat. Chem. Biol (in press)
  • Peer Reviewed
• [Journal Article] Roles of PU. 1 in monocyte- and mast cell-specific gene regulation
  • Author(s): Ito, T., Nishiyama, C., Nakano, N., Nishiyama, M., Usui, Y., Takeda, K., Kanada, S., Fukuyama, K., Akiba, H., Tokura, T., Hara, M., Tsuboi, R., Ogawa, H., Okumura, K.
  • Journal Title: Int. Immunol (in press)
  • Peer Reviewed
• [Journal Article] Tissue factor (TF) +5466A>G polymorphism predicts plasma TF levels in subjects with cryptogenic ischemic stroke
  • Author(s): Potaczek, D., Pieculewicz, M., Mazur, M., Branicka, A., Nishiyama, C., Okumura, K., Undas, A.
  • Journal Title: Thromb. Haemost (in press)
  • Peer Reviewed
• [Journal Article] FCER1A genetic variability and serum
  • Author(s): Potaczek, D., Okumura, K. Nishiyama, C.
  • Journal Title: IgE levels (Allergy in press)
  • Peer Reviewed
• [Journal Article] Very genotype of tissue factor +5466A>G mutation in a patient with two cryptogenic cerebovascular ischemic events
  • Author(s): Potaczek, D., Pieculewicz, M., Mazur, M., Branicka, A., Nishiyama, C., Okumura, K., Undas, A.
  • Journal Title: Int. J. Cardiology (in press)
  • Peer Reviewed
• [Journal Article] Genetic variability of the high-affinity IgE receptor alpha-subunit
  • Author(s): Potaczek, D., Nishiyama, C., Sanak, M., Szczeklik, A., Okumura, K.
  • Journal Title: Immunol. Res (in press)
  • Peer Reviewed
• [Presentation] PU. 1 determines the magnitude and kinetics of cytokine production (2008)
  • Author(s): 深井達夫、他
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-03
• [Presentation] Regulation mechanism of Notch signaling-mediated MHC class II expression on mast cells (2008)
  • Author(s): 中野信浩、他
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-03
• [Presentation] Regulation of c-kit gene expression in mast cells (2008)
  • Author(s): 前田啓子、他
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-03
• [Presentation] Role of transcription factor GATA-1 in commitment between dendritic cells and mast cells (2008)
  • Author(s): 下川直美、他
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-03
• [Presentation] Role of transcription factor GATA-1 in commitment between dendritic cells and mast cells (2008)
  • Author(s): 下川 直美
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-03
• [Presentation] Regulation of c-kit gene expression in mast cells (2008)
  • Author(s): 前田 啓子
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-03
• [Presentation] Regulation mechanism of Notch signaling-mediated MHC class II expression on mast cells (2008)
  • Author(s): 中野 信浩
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-03
• [Presentation] PU. 1 determines the magnitude and kinetics of cytokine production (2008)
  • Author(s): 深井 達夫
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-03
• [Presentation] The role of transcription factor PU. 1 in the regulation of CD80 and CD86 expression (2008)
  • Author(s): 金田俊介、他
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-02
• [Presentation] The role of transcription factor PU. 1 in the regulation of CD80 and CD86 expression (2008)
  • Author(s): 金田 俊介
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-02
• [Presentation] Analysis of linkage, haplotypes and function of FCER2 genetic polymorphisms and its possible implications (2008)
  • Author(s): Daniel Potaczek、他
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-01
• [Presentation] Roles of programmed death-1(PD-1)/PD-1 ligands pathway in the development of murine experimental autoimmune uveoretinitis (EAU) (2008)
  • Author(s): 臼井嘉彦、他
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-01
• [Presentation] Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine experimental autoimmune uveoretinitis (EAU) (2008)
  • Author(s): 臼井 嘉彦
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-01
• [Presentation] Analysis of linkage, haplotypes and function of FCER2 genetic polymorphisms and its possible implleations (2008)
  • Author(s): Daniel Potaczek
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-01
• [Presentation] Functional analysis of FCER1A -18483A>C polymorphism (2008)
  • Author(s): Daniel Potaczek、他
  • Organizer: 日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京(東京国際フォーラム)
  • Year and Date: 2008-11-27
• [Presentation] IL-12/23p40遺伝子のプロモーター領域における遺伝子多型の機能解析 (2008)
  • Author(s): 下川直美、他
  • Organizer: 日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京(東京国際フォーラム)
  • Year and Date: 2008-11-27
• [Presentation] Notchシグナルによりマスト細胞が獲得する抗原提示細胞機能 (2008)
  • Author(s): 中野信浩、他
  • Organizer: 日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京(東京国際フォーラム)
  • Year and Date: 2008-11-27
• [Presentation] CD80、86発現における転写調節因子PU. 1の役割 (2008)
  • Author(s): 金田俊介、他
  • Organizer: 日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京(東京国際フォーラム)
  • Year and Date: 2008-11-27
• [Presentation] CD80、CD86発現における転写調節因子PU. 1の役割 (2008)
  • Author(s): 金田 俊介
  • Organizer: 日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京(東京国際フォーラム)
  • Year and Date: 2008-11-27
• [Presentation] Functional analysis of FCER1A -18483A > C polymorphism (2008)
  • Author(s): Daniel Potaczek
  • Organizer: 日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京(東京国際フォーラム)
  • Year and Date: 2008-11-27
• [Presentation] Role of Elf-1 on FcepsilonRI gene expression of mast cells (2008)
  • Author(s): 王慶輝、他
  • Organizer: 日本アレルギー学会春季臨床大会
  • Place of Presentation: 東京(ホテル日航東京)
  • Year and Date: 2008-06-12
• [Presentation] hermus thermophilusのリジン生合成における新規アミノ基修飾システムの発見 (2008)
  • Author(s): 堀江暁、他
  • Organizer: 日本農芸化学会2008年度大会
  • Place of Presentation: 名古屋(名城大学)
  • Year and Date: 2008-03-28
• [Presentation] Notchシグナルによるマスト細胞の抗原提示細胞機能の獲得 (2008)
  • Author(s): 中野信浩、他
  • Organizer: 日本農芸化学会2008年度大会
  • Place of Presentation: 名古屋(名城大学)
  • Year and Date: 2008-03-27
• [Presentation] Notchシグナルによるマスト細胞の抗原提示細胞機能の獲得 (2008)
  • Author(s): 中野 信浩
  • Organizer: 日本農芸化学会
  • Place of Presentation: 東京(グランドプリンスホテル高輪)
  • Year and Date: 2008-03-27
• [Presentation] Notchシグナルによるマスト細胞表面上のMHC classII発現誘導 (2007)
  • Author(s): 中野信浩、他
  • Organizer: 日本免疫学会2007年度大会
  • Place of Presentation: 東京(グランドプリンスホテル高輪)
  • Year and Date: 2007-11-21
• [Presentation] Microarray-Pathway解析により同定されたPU. 1制御下のFcepsilonRIシグナル伝達系 (2007)
  • Author(s): 丹羽祐介、他
  • Organizer: 日本免疫学会2007年度大会
  • Place of Presentation: 東京(グランドプリンスホテル高輪)
  • Year and Date: 2007-11-21
• [Presentation] Role of transcription factor GATA-1 in commitment between dendritic cells and mast cells (2007)
  • Author(s): 下川直美、他
  • Organizer: 日本免疫学会2007年度大会
  • Place of Presentation: 東京(グランドプリンスホテル高輪)
  • Year and Date: 2007-11-21
• [Presentation] マスト細胞におけるc-kit遺伝子の発現調節機構 (2007)
  • Author(s): 前田啓子、他
  • Organizer: 日本免疫学会2007年度大会
  • Place of Presentation: 東京(グランドプリンスホテル高輪)
  • Year and Date: 2007-11-21
• [Presentation] マスト細胞におけるc-kit遺伝子の発現調節機構 (2007)
  • Author(s): 前田 啓子
  • Organizer: 日本免疫学会
  • Place of Presentation: 東京(グランドプリンスホテル高輪)
  • Year and Date: 2007-11-21
• [Presentation] Role of transcription factor GATA-1 in commitment between dendritic cells and mast cells (2007)
  • Author(s): 下川 直美
  • Organizer: 日本免疫学会
  • Place of Presentation: 東京(グランドプリンスホテル高輪)
  • Year and Date: 2007-11-21
• [Presentation] Microarray-Pathway解析により同定されたPU.1制御下のFceRIシグナル伝達系 (2007)
  • Author(s): 丹羽 祐介
  • Organizer: 日本免疫学会
  • Place of Presentation: 東京(グランドプリンスホテル高輪)
  • Year and Date: 2007-11-21
• [Presentation] Notchシグナルによるマスト細胞表面上へのMHC class II発現誘導 (2007)
  • Author(s): 中野 信浩
  • Organizer: 日本免疫学会
  • Place of Presentation: 東京(グランドプリンスホテル高輪)
  • Year and Date: 2007-11-21
• [Presentation] 細胞外刺激に応答した角化細胞のNotchリガンド発現調節 (2007)
  • Author(s): 深井達夫、他
  • Organizer: 日本アレルギー学会2007年度大会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-11-02
• [Presentation] マスト細胞・単球系細胞の分岐決定における転写因子GATA-1の機能的役割 (2007)
  • Author(s): 下川直美、他
  • Organizer: 日本アレルギー学会2007年度大会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-11-02
• [Presentation] マスト細胞におけるNotchシグナルにより誘導されるMHC classIIの発現誘導 (2007)
  • Author(s): 中野信浩、他
  • Organizer: 日本アレルギー学会2007年度大会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-11-02
• [Presentation] マスト細胞におけるNotchシグナルにより誘導されるMHC classIIの発現誘導機構解析 (2007)
  • Author(s): 中野 信浩
  • Organizer: 日本アレルギー学会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-11-02
• [Presentation] マスト細胞・単球系細胞の分岐決定における転写因子GATA-1の機能的役割 (2007)
  • Author(s): 下川 直美
  • Organizer: 日本アレルギー学会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-11-02
• [Presentation] 細胞外刺激因子に応答した角化細胞のNotchリガンド発現調節 (2007)
  • Author(s): 深井 達夫
  • Organizer: 日本アレルギー学会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-11-02
• [Presentation] リンゴポリフェノール低分子画分の抗アレルギー作用点の解析 (2007)
  • Author(s): 中野信浩、他
  • Organizer: 日本農芸化学会2007年度大会
  • Place of Presentation: 東京(東京農大)
  • Year and Date: 2007-03-25
• [Presentation] マウス樹状細胞特異的遺伝子の発現調節機構の解明 (2007)
  • Author(s): 横山北斗、他
  • Organizer: 日本農芸化学会2007年度大会
  • Place of Presentation: 東京(東京農大)
  • Year and Date: 2007-03-25
• [Presentation] 転写調節因子GATA-1を介したマスト細胞特異的遺伝子発現制御 (2007)
  • Author(s): 西山千春、他
  • Organizer: 日本農芸化学会2007年度大会
  • Place of Presentation: 東京(東京農大)
  • Year and Date: 2007-03-25
• [Presentation] 転写調節因子GATA-1を介したマスト細胞特異的遺伝子発現制御 (2007)
  • Author(s): 西山 千春
  • Organizer: 日本農芸化学会
  • Place of Presentation: 東京(東京農大)
  • Year and Date: 2007-03-25
• [Presentation] マウス樹状細胞特異的遺伝子の発現調節機構の解明 (2007)
  • Author(s): 横山 北斗
  • Organizer: 日本農芸化学会
  • Place of Presentation: 東京(東京農大)
  • Year and Date: 2007-03-25
• [Presentation] リンゴポリフェノール低分子画分の抗アレルギー作用点の解析 (2007)
  • Author(s): 中野 信浩
  • Organizer: 日本農芸化学会
  • Place of Presentation: 東京(東京農大)
  • Year and Date: 2007-03-25
• [Book] 臨床免疫・アレルギー科 (2009)
  • Author(s): 西山千春
  • Publisher: FcεRIα鎖の発現調節
• [Book] 分子細胞治療 (2008)
  • Author(s): 西山千春
  • Publisher: アレルギー(アトピー)のゲノム解析
• [Book] 「分子細胞治療」2008年6月号、アレルギー(アトピー)のゲノム解析 (2008)
  • Author(s): 西山 千春
  • Publisher: 先端医学社
• [Remarks] 【アウトリーチ活動】免疫ふしぎ未来(免疫学会)2008 年、2009年実行委員
• [Remarks] 【賞罰】2005年農芸化学奨励賞受賞第16回(平成17年度)アボットジャパン・アレルギー学術奨励賞受賞
• [Remarks] 研究成果
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/k9.html
• [Remarks] プロフィール
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/keireki_nishiyama.html
• [Remarks] 研究テーマ
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/kenkyu_nishiyama.html