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Analyses of serum cytokine and metabolism of exta-cellular protein matrix for purpose of making a therapeutic strategy for Kawasaki disease

Research Project

Project/Area Number 19591199
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionGunma University

Principal Investigator

ARAKAWA Hirokazu (2008)  Gunma University, 大学院・医学系研究科, 教授 (50272232)

井上 佳也 (2007)  Gunma University, 大学院・医学系研究科, 講師 (00334087)

Co-Investigator(Kenkyū-buntansha) MORIKAWA Akihiro  群馬大学, 名誉教授 (40125878)
KOBAYASHI Tohru  群馬大学, 医学部, 助教 (50431713)
荒川 浩一  群馬大学, 医学部, 講師 (50272232)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords川崎病 / 循環器学 / ステロイド / 多施設前方視的治療研究 / MMP
Research Abstract

群馬大学で行われた無作為化比較試験保存血清を用い、細胞外マトリックス分解酵素・サイトカイン・ケモカイン等の測定を行い重症度(リスクスコア)との関連を検証した。結果リスクスコア点数はIL-6、IL-7、IL-8、IL-10、IL-17、G-CSF、MIP-1α、ICAM-1、MMP3と有意に相関していた。また、初期治療開始2日目のIL-6、IL-10、G-CSF、ICAM-1はIVIG群に比べIVIG+PSL群が有意に低値であった。MMP-3は他のmarkerとは逆にIVIG+PSLによる介入で高値にIVIG+PSL療法はより速やかに血管炎をdown-regulationすることによって予後改善に寄与している可能性が示された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (44 results)

All 2009 2008 2007 Other

All Journal Article (13 results) (of which Peer Reviewed: 9 results) Presentation (31 results)

  • [Journal Article] Risk stratification in the decision to include prednisolone with intravenous immunoglobulin in primary therapy for Kawasaki disease2009

    • Author(s)
      Kobayashi T, Inoue Y, Otani T, Morikawa A, Kobayashi T, Takeuchi K, Saji T, Sonobe T, Ogawa S, Miura M, Arakawa H
    • Journal Title

      Pediatr Infect Dis J(in Press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ガンマグロブリン不応例の予測と層別化2009

    • Author(s)
      小林徹、小林富男、荒川浩一
    • Journal Title

      小児内科 41

      Pages: 69-72

    • Related Report
      2008 Final Research Report
  • [Journal Article] Risk stratification in the decision to include prednisolone with intravenous immunoglobulin in primary therapy for Kawasaki disease.2009

    • Author(s)
      Kobayashi T, Inoue Y, Otani T, Morikawa A, Kobayashi T, Takeuchi K, Saji T, Sonobe T, 0gawa S, Miura M, Arakawa H.
    • Journal Title

      Pediatr Infect Dis J. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ガンマグロブリン不応例切予測と層別化2009

    • Author(s)
      小林徹、小林富男、荒川浩一
    • Journal Title

      小児内科 41

      Pages: 69-72

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 無効例の予測および層別化2008

    • Author(s)
      小林徹、井上佳也、森川昭廣
    • Journal Title

      日本臨床 66

      Pages: 332-337

    • Related Report
      2008 Final Research Report
  • [Journal Article] 無効例の予測および層別化2008

    • Author(s)
      小林徹,井上佳也,森川昭廣
    • Journal Title

      日本臨床 66

      Pages: 332-337

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 免疫グロブリン無効例の予測および治療層別化2008

    • Author(s)
      小林 徹, 井上 佳也, 森川 昭廣
    • Journal Title

      日本臨床 66

      Pages: 332-337

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of Kawasaki disease2007

    • Author(s)
      Inoue Y, Kobayashi T, Morikawa A
    • Journal Title

      N Engl J Med 356

      Pages: 2746-2747

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased CD11b expression on polymorphonuclear leucocytes and cytokine profiles in patients with Kawasaki disease2007

    • Author(s)
      Kobayashi T, Kimura H(他5名、1番目7番目)
    • Journal Title

      Clin Exp Immunol 148

      Pages: 112-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] External validation of a scoring system to predict resistance to intravenous immunoglobulin2007

    • Author(s)
      Kobayashi T, Inoue Y, Tamura K, Morikawa A, Kobayashi T
    • Journal Title

      J Pediatr 150

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of Kawasaki disease2007

    • Author(s)
      Inoue Y, Kobayashi T, Morikawa A.
    • Journal Title

      N Engl J Med 356

      Pages: 2746-2747

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extemal vahdation of scoring system to predict resistance to intravenous immunoglobulin2007

    • Author(s)
      Kobayashi T, Inoue Y, Tamura K, Kobayashi T, Morikawa A.
    • Journal Title

      J Pediatr 150

      Pages: 37-37

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased CDllb expression on polymorphonuclear leukocytes and cytokine profiles in patients with Kawasaki disease.2007

    • Author(s)
      Kobayashi T, Kimura H, Okada Y, Inoue Y, Kobayashi T, Shinohara M, Morikawa A.
    • Journal Title

      Clin Exp Immunol 142

      Pages: 112-118

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 免疫グロブリン不応例に対する治療戦略2008

    • Author(s)
      小林徹
    • Organizer
      香川川崎病講演会
    • Place of Presentation
      高松
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 川崎病に対する新たな治療戦略-RAISE Studyの概略-2008

    • Author(s)
      小林徹
    • Organizer
      第27回名古屋大学大学院セミナー
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 川崎病初期治療の層別化ステロイド治療2008

    • Author(s)
      小林徹
    • Organizer
      第6回栃木川崎病研究会
    • Place of Presentation
      宇都宮
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] シクロスポリンが著効したガンマグロブリン、プレドニゾロン療法不応の2例2008

    • Author(s)
      池田健太郎、石井陽一郎、小林富男、小林徹
    • Organizer
      第28回日本川崎病研究会
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] IVIG抵抗例に対する追加治療としてのプレドニゾロン投与は予後を改善するか2008

    • Author(s)
      小林徹、小林富男、岡田恭典、渡邊正之、鈴木尊裕、下山伸哉、池田健太郎、石井陽一郎、荒川浩一
    • Organizer
      第29回日本川崎病研究会シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 川崎病初期治療の層別化とステロイド治療の可能性2008

    • Author(s)
      小林徹
    • Organizer
      埼玉川崎病講演会
    • Place of Presentation
      さいたま市
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 川崎病初期治療の層別化とステロイド治療の可能性2008

    • Author(s)
      小林徹
    • Organizer
      第4回静岡川崎病研究会
    • Place of Presentation
      静岡
    • Year and Date
      2008-08-09
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] A new scoring system to predict intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease2008

    • Author(s)
      Shimoyama S, Kobayashi T, Inoue Y, Takeuchi K, Kobayashi T, Okada Y, Tamura K, Tomomasa T, Otani T, Arakawa H , Morikawa A
    • Organizer
      14th World Congress on Heart Disease, The International Academy of Cardiology Annual Scientific Sessions 2008
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-28
    • Related Report
      2008 Final Research Report
  • [Presentation] A new scoring system to predict intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease.2008

    • Author(s)
      Shimoyama S, Kobayashi T, Inoue Y, Takeuchi K, Kobayashi T, Okada Y, Tamura K, Tomomasa T, Otani T, Arakawa H, Morikawa A.
    • Organizer
      14th World Congress on Heart Disease, The International Academy of Cardiology Annual Scientific Sessions 2008
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 川崎病初期治療の層別化とステロイド治療の可能性2008

    • Author(s)
      小林徹
    • Organizer
      第10回群馬川崎病研究会
    • Place of Presentation
      前橋
    • Year and Date
      2008-07-16
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 川崎病初期治療の層別化とステロイド治療の可能性2008

    • Author(s)
      小林徹
    • Organizer
      第44回日本小児循環器学会学術集会
    • Place of Presentation
      郡山
    • Year and Date
      2008-07-04
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 川崎病とステロイド治療2008

    • Author(s)
      小林徹
    • Organizer
      二水会学術講演会
    • Place of Presentation
      熊谷
    • Year and Date
      2008-06-03
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Risk stratification in the decision to include prednisolone with intravenous immunoglobulin in primary therapy of Kawasaki disease2008

    • Author(s)
      Kobayashi T, Inoue Y, Otani T, Kobayashi T, Takeuchi K, Saji T, Sonobe T, Ogawa S, Miura M, Seki M, Ikeda K,Ishii Y, Suzuki T, Shimoyama S, Morikawa A
    • Organizer
      Pediatric Academic Society 2008
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2008-05-04
    • Related Report
      2008 Final Research Report
  • [Presentation] External Validation Of A Risk Score To Predict Intravenous Immunoglobulin Unresponsiveness In Patients With Kawasaki Disease2008

    • Author(s)
      Seki M, Kobayashi T,Inoue Y, Ayusawa M, Nakamura T, Kobayashi T, Ikeda K, Ishii Y, Suzuki T, Shimoyama S, Morikawa A
    • Organizer
      Pediatric Academic Society 2008
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2008-05-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Risk stratification in the decision to include prednisolone with intravenous immunoglobulin in primary therapy of Kawasaki disease.2008

    • Author(s)
      Kobayashi T, Inoue Y, Otani T, Kobayashi T, Takeuchi K, Saji T, Sonobe T, Ogawa S, Miura M, Seki M, Ikeda K, Ishii Y, Suzuki T, Shimoyama S, Morikawa A.
    • Organizer
      Pediatric Academic Society 2008
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2008-05-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] External Validation Of A Risk Score To Predict Intravenous Immunoglobul in Unresponsiveness In Patients With Kawasaki Disease.2008

    • Author(s)
      Seki M, Kobayashi T. Inoue Y. Ayusawa M, Nakamura T, Kobayashi T, Ikeda K, Ishii Y, Suzuki T, Shimoyama S, Morikawa A.
    • Organizer
      Pediatric Academic Society 2008
    • Place of Presentation
      Honolulu, Hawaii, USA.
    • Year and Date
      2008-05-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 川崎病患者における免疫グロブリン抵抗例の予測と治療層別化の可能性2008

    • Author(s)
      小林徹
    • Organizer
      第111回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-27
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 川崎病患者の層別化と免疫グロブリンプレドニゾロン初期併用療法の効果2008

    • Author(s)
      小林徹、井上佳也、岡田恭典、小林富男、田村一志、関満、池田健太郎, 石井陽一郎, 荒川浩一, 森川昭廣
    • Organizer
      第111回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-26
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Risk stratification in the decision to include prednisolone with intravenous immunoglobulin in primary therapy of Kawasaki disease2008

    • Author(s)
      Suzuki T, Kobayashi T, Inoue Y, Otani T, Kobayashi T, Takeuchi K, Seki M, Ikeda K, Ishii Y, Shimoyama S, Morikawa A
    • Organizer
      9th International Kawasaki Disease Symposium
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-04-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Adverse effects from corticosteroids therapy for acte phase Kawasaki disease.2008

    • Author(s)
      Kobayashi T, Kobayashi T, Shinohara M. Sone K, Ikeda K, Suzuki T, Shimoyama S, Seki M, Okada Y.
    • Organizer
      9th International Kawasaki Disease Symposium
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-04-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Risk stratification in the decision to include prednisolone with intravenous immunoglobulin in primary therapy of Kawasaki disease.2008

    • Author(s)
      Suzuki T, Kobayashi T, Inoue Y, Otani T, Kobayashi T, Takeuchi K, Seki M, Ikeda K, Ishii Y, Shimoyama S, Morikawa A.
    • Organizer
      9th International Kawasaki Disease Symposium
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-04-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] A simple risk score to predict intravenous immunoglobulin non-responders in patients with Kawasaki disease2008

    • Author(s)
      Kobayashi T, Inoue Y, Takeuchi K, Okada Y, Kobayashi T, Tamura K, Tomomasa T, Morikawa A
    • Organizer
      9 International Kawasaki Disease Symposium
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-04-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Asimple risk score to predict intravenous immunoglobulin non-responders in patients with Kawasaki disease.2008

    • Author(s)
      Kobayashi T, Inoue Y, Takeuchi K, Okada Y, Kobayashi T, Tamura K, Tomomasa T, Morikawa A.
    • Organizer
      9th International Kawasaki Disease Symposium
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-04-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 免疫グロブリン抵抗例の予測と治療層別化2008

    • Author(s)
      小林徹
    • Organizer
      奈良川崎病講演会
    • Place of Presentation
      奈良
    • Year and Date
      2008-03-23
    • Related Report
      2008 Final Research Report
  • [Presentation] 免疫グロブリン抵抗例の予測と治療層別化2008

    • Author(s)
      小林徹
    • Organizer
      第5回信州川崎病フォーラム
    • Place of Presentation
      松本
    • Year and Date
      2008-01-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Prediction of intravenous immunoglobulin non-responders in patients with Kawasaki disease2007

    • Author(s)
      Kobayashi T, Kobayashi T, Inoue Y, Takeuchi K, Okada Y, Tamura K, Tomomasa T, Morikawa A
    • Organizer
      7^<th> International Congress on Coronary Artery Disease
    • Place of Presentation
      Venice, Italy
    • Year and Date
      2007-10-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Stratified selection of primary therapy based on a risk score in Kawasaki disease : Benefit of intravenous immunoglobulin and prednisolone2007

    • Author(s)
      Ishii Y, Kobayashi T, Inoue Y, Kobayashi T, Okada Y, Takeuchi K, Tamura K, Tomomasa T, Ikeda K, Seki M, Shimoyama S, Suzuki T, Morikawa A
    • Organizer
      7th International Congress on Coronary Artery Disease
    • Place of Presentation
      Venice, Italy
    • Year and Date
      2007-10-09
    • Related Report
      2008 Final Research Report
  • [Presentation] リスクスコアは免疫グロブリン2g/kg単回療法に適用可能か?2007

    • Author(s)
      小林徹、小林富男、池田健太郎、井上佳也、岡田恭典、渡邊正之、関満、鈴木尊裕、下山伸哉、石井陽一
    • Organizer
      第43回日本小児循環器学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-05
    • Related Report
      2008 Final Research Report
  • [Presentation] リスクスコアを用いた川崎病患者の層別化とステロイド初期投与の有用性2007

    • Author(s)
      小林徹、井上佳也、岡田恭典、友政剛、田村一志、小林富男、篠原真、森川昭廣
    • Organizer
      第110回日本小児科学会学術集
    • Place of Presentation
      京都
    • Year and Date
      2007-04-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 重症川崎病に対するガンマグロブリンステロイド初期併用療法の効果2007

    • Author(s)
      小林徹、小林富男、池田健太郎、井上佳也、田村一志、岡田恭典、友政剛、森川昭廣
    • Organizer
      第110回日本小児科学会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Adverse effects from corticosteroids therapy for acte phase Kawasaki disease

    • Author(s)
      Kobayashi T, Kobayashi T, Shinohara M, Sone K, Ikeda K, Suzuki T, Shimoyama S, Seki M, Okada Y
    • Organizer
      9th International Kawasaki Disease Symposium. 12 April, 2008
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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