• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular basis of pulmonary hypertension using mice deficient ina causative gene and an oxidant stress-related gene

Research Project

Project/Area Number 19591202
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionMie University

Principal Investigator

YOSHIHIDE Mitani  Mie University, 医学部・附属病院, 講師 (60273380)

Co-Investigator(Kenkyū-buntansha) HIDETO Shimpo  三重大学, 大学院・医学系研究科, 教授 (70179076)
KAZUO Maruyama  三重大学, 大学院・医学系研究科, 教授 (20181828)
澤田 博文  三重大学, 医学部附属病院, 診療等従事者 (30362354)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺高血圧 / 原因遺伝子 / 酸化ストレス / 動物モデル / 骨形成蛋白受容体 / 炎症 / 遺伝子異常 / 骨形成蛋白 / 転写因子
Research Abstract

小児期難病である肺高血圧の病態の為に、遺伝素因と環境因子に関係する酸化ストレスに着目し、それぞれの遺伝子改変マウスを用いて新しい動物モデルを作成した。各々単独の遺伝子欠損マウスでは、慢性低酸素刺激による肺高血圧を増悪しなかったが、両者の遺伝子欠損マウスでは、慢性低酸素暴露による肺高血圧を増悪した。この事は、酸化ストレスを介する機序が遺伝性肺高血圧発症に重要性を示唆し、新たな治療標的を提示する。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (48 results)

All 2009 2008 2007

All Journal Article (28 results) (of which Peer Reviewed: 23 results) Presentation (19 results) Book (1 results)

  • [Journal Article] In Vivo Plaque Composition and Morphologyin Coronary Artery Lesions in TheAdolescents and Young Adults Long AfterKawasaki Disease2009

    • Author(s)
      Mitani Y(1), Ohashi H(2),Maruyama K(7),Shimpo H(8),計9名
    • Journal Title

      A Virtual Histology-Intravascular Ultrasound StudyCirculation (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Removal of prostaglandin E2 and increasedintraoperative blood pressure duringmodified ultrafiltration in pediatriccardiac surgery2009

    • Author(s)
      Yokoyama K(1), Mitani Y(4), Shimpo H (7), 計7名
    • Journal Title

      J Thorac Cardiovasc Surg 137(3)

      Pages: 730-5

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Removal of prostaglandin E2 and increased intraoperative blood pressure during modified ultrafiltration in pediatric cardiac surgery.2009

    • Author(s)
      Yokoyama K, Takabayashi S, Komada T, Onoda K, Mitani Y, Iwata H, Shimpo H.
    • Journal Title

      J Thorac Cardiovasc Surg 137

      Pages: 730-735

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atrial natriuretic peptide genetransfection with a novel envelope vectorsystem ameliorates pulmonary hypertensionin rats2008

    • Author(s)
      Mitani Y(1), Shimpo H(5), Maruyama K(9), 計9名
    • Journal Title

      J Thorac Cardiovasc Surg 136(1)

      Pages: 142-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A persistent infiltrated lung shadow inan infant : A rare association ofcongenital pulmonary venous obstructionwith partial anomalous pulmonary venousconnection and ventricular septaldefect2008

    • Author(s)
      Iwasa T(1), Mitani Y(2), Shimpo H, (5), 計7名
    • Journal Title

      Ped Int 50(3)

      Pages: 397-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary artery growth after Norwood andbidirectional Glenn procedureInteract Cardiovasc Thorac Surg2008

    • Author(s)
      Takabayashi S(1), Mitani Y(2), Shimpo H(4), 計4名
    • Journal Title

      7(2)

      Pages: 328-30

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fatal pulmonary lymphangiectasiamanifesting after repeated surgeries forintractable chylopericardium andchylothorax in a 20-month-old girl2008

    • Author(s)
      Kamada N(1), Mitani Y(2), Shimpo H(10), 計11名
    • Journal Title

      Circulation 117

      Pages: 1894-1896

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suture repair of pectus excavatum at thetime of cardiac surgery on an infantAnn Thorac Surg2008

    • Author(s)
      Takabayashi S(1), Ohashi H(4), MitaniY(4), Shimpo H(5), 計4名
    • Journal Title

      Ann Thorac Surg 85(2)

      Pages: 651-3

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特集 : 小児疾患診療のための病態生理-原発性肺高血圧(総説)2008

    • Author(s)
      三谷義英
    • Journal Title

      小児内科(東京医学社) 40

      Pages: 350-356

    • Related Report
      2008 Final Research Report
  • [Journal Article] 特集 : 肺動脈性肺高血圧-スクリーニング検査(総説)2008

    • Author(s)
      三谷義英
    • Journal Title

      日本臨床社、日本臨床 66(11)

    • Related Report
      2008 Final Research Report
  • [Journal Article] 肺高血圧症の発症機序-overview(総説)2008

    • Author(s)
      三谷義英
    • Journal Title

      先端医学社、分子心血管病 9(4)

      Pages: 339-346

    • Related Report
      2008 Final Research Report
  • [Journal Article] Fatal pulmonary lymphangiectasia manifesting after repeated surgeries for intractable chylopericardium and chylothorax in a 20-month-old girl.2008

    • Author(s)
      Kamada N, Mitani Y, Kihira K, Iwao A, Sinoki T, Ikeyama Y, Sawada H, Deguchi T, Takabayashi S, Shimpo H, Komada Y.
    • Journal Title

      Circulation 117

      Pages: 1894-1896

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atrial natriuretic peptide gene transfection with a novel envelope vector system ameliorates pulmonary hypertension in rats.2008

    • Author(s)
      Mitani Y, Maruyama J, Jiang BH, Sawada H, Shimpo H, Imanaka-Yoshida K, Kaneda Y, Komada Y, Maruyama K.
    • Journal Title

      J Thorac Cardiovasc Surg 136

      Pages: 142-149

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺動脈性肺高血圧-スクリーニング検査(総説)2008

    • Author(s)
      三谷義英
    • Journal Title

      小児内科 40

      Pages: 350-356

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 肺高血圧症の発症機序-overview (総説)2008

    • Author(s)
      三谷義英
    • Journal Title

      日本臨床 66

      Pages: 2102-2106

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Suture repair of pectus excavatum at the time of cardiac surgery on an infant2008

    • Author(s)
      Takabayashi S, Mitani Y, et. al.
    • Journal Title

      Ann Thorac Surg 85

      Pages: 651-653

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A nuclear factor-κB inhibitor pyrrolidine dithiocarbamate ameriolates pulmonary hypertension in rats2007

    • Author(s)
      Sawada H(1), Mitani Y(2), Shimpo H(8), Maruyama K(10)
    • Journal Title

      Chest 132(4)

      Pages: 1265-1274

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Inhibitor of Inducible Nitric Oxide Synthase, ONO-1714, Does Not Ameliorate Hypoxia-induced Pulmonary Hypertension in Rats2007

    • Author(s)
      Jiang BH(1), Mitani Y(4), Maruyama K(5)
    • Journal Title

      Lung 185(5)

      Pages: 303-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced regional right ventricular wallmotion after transventricular repair oftetralogy of Fallot2007

    • Author(s)
      Takabayashi S(1), Shimpo H(2), Mitani Y(5)
    • Journal Title

      J Thorac Cardiovasc Surg 133(6)

      Pages: 1656-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fate of the 'opened' arterial duct:Lessons learned from bilateral pulmonaryartery banding for hypoplastic left heartsyndrome under the continuous infusion ofprostaglandin E12007

    • Author(s)
      Mitani Y(1), Ohashi H(4), Maruyama K(8), Shimpo H(9)
    • Journal Title

      J Thorac Cardiovasc Surg 133(6)

      Pages: 1653-4

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reversal of increased pulmonary arterialpressure associated with systemic venouscollaterals after tonsillectomy in aFontan candidate after Glenn procedure:Impact of obstructive sleep apnea onFontan circulation2007

    • Author(s)
      Sawada H(1), Mitani Y(2), Shimpo H(7), Maruyama K(8)
    • Journal Title

      J Thorac Cardiovasc Surg 133(5)

      Pages: 1371-3

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Palliative management of alow-birth-weight infant with congenitallycorrected transposition of the great arteries,severe restrictive foramen ovale,hypoplasia of the morphologically rightventricle, ventricular septal defect, andsteno-insufficiency of the tricuspidvalve2007

    • Author(s)
      Takabayashi S(1), Shimpo H(2), Mitani Y(5)
    • Journal Title

      Gen Thorac Cardiovasc Surg 55(4)

      Pages: 163-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fate of the‘opened'arterial duct:Lessons learned from bilateral pulmonary artery banding for hypoplastic left heart syndrome under the continuous infusion of prostaglandin E12007

    • Author(s)
      Mitani Y, Ohashi H, et. al.
    • Journal Title

      J Thorac Cardiovasc Surg 133

      Pages: 1653-1654

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A nuclear factor-κB inhibitor pyrrolidine dithiocarbamate ameriolates pulmonary hypertension in rats.2007

    • Author(s)
      Sawada H, Mitani Y, et. al.
    • Journal Title

      Chest 133

      Pages: 1265-1274

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Inhibitor of Inducible Nitric Oxide Synthase,ONO-1714,Does Not Amehorate Hypoxia-induced Puhnoary Hypertension in Rats.2007

    • Author(s)
      Jiang BH, Mitani Y, et. al.
    • Journal Title

      Lung 185

      Pages: 303-308

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palliative management of a low-birth-weight infant with congenitally corrected transposition of the great arteries,severe restrictive foramen ovale,hypoplasia of the morphologically right ventricle,ventricular septaldefect,and stenoinsufficiency of the tricuspid valve2007

    • Author(s)
      Takabayashi S, Mitani Y, et. al.
    • Journal Title

      Gen Thorac Cardiovasc Surg 55

      Pages: 163-166

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reversal of increased pulmonary arterial pressure associated with systemic venous collaterals after tonsillectomy in a Fontan candidate after Glenn procedure:Impact of obstructive sleep apnea on Fontan circulation.2007

    • Author(s)
      Sawada H, Mitani Y, et. al.
    • Journal Title

      J Thorac Cardiovasc Surg 133

      Pages: 1371-1373

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced regional right ventricular wall motion after transventricular repair of tetralogy of Fallot.2007

    • Author(s)
      Takabayashi S, Mitani Y, et. al.
    • Journal Title

      J Thorac Cardiovasc Surg 133

      Pages: 1656-1658

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Eisenmenger 症候群を除く肺血管病変を伴う先天性心疾患に対するボセンタンの効果2009

    • Author(s)
      大橋啓之(1)、三谷義英(2)、新保秀人(7)、計7名
    • Organizer
      第44回日本小児循環器学会総会
    • Place of Presentation
      郡山市
    • Year and Date
      2009-07-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Bosentan Promotes Incorporation of Bone Marrow-Derived Endothelial Progenitor Cells but Inhibits Infiltration of Macrophages into Pulmonary VascularLesions in Mice Exposed to ChronicHypoxia : A New Mechanism of Bosentan in Inhibiting Pulmonary Hypertension2009

    • Author(s)
      Kato T(1), Shimpo H(9), Maruyama K(10), Mitani Y(12), 計12名
    • Organizer
      Japanese Circulation Society
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Bosentan Promotes Incorporation of Bone Marrow-Derived Endothelial Progenitor Cells but Inhibits Infiltration of Macrophages into Pulmonary Vascular Lesions in Mice Exposed to Chronic Hypoxia : A New Mechanism of Bosentan in Inhibiting Pulmonary Hypertension2009

    • Author(s)
      Kato T, Shimpo H, Maruyama K, Mitani Y.
    • Organizer
      Japanese Circulation Society
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chronic hypoxia increases bonemarrow-derived endothelial cells ofnon-hematopoietic stem cell origin, aswell as macrophages of hematopoietic stemcell origin, in pulmonary vascular lesionsin mice : differential roles of bonemarrow-derived hematopoietic andnon-hematopoietic stem cells in pulmonaryhypertension2008

    • Author(s)
      Kato T(1), Shimpo H(8), Maruyama K(9), Mitani Y(11), 計11名
    • Organizer
      American Heart Association, New Orleans
    • Place of Presentation
      US
    • Year and Date
      2008-11-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Necrotic Core and Dense Calcium, not Fibrous, Components contribute to anIncreased Plaque Burden Associated with Localized Stenosis in Patients Long afterKawasaki Disease: Quantitative GrayScale-andVirtual Histology-IntravascularUltrasoundStudy2008

    • Author(s)
      Mitani Y(1), Ohashi H(2), 計5名
    • Organizer
      American Heart Association, New Orleans
    • Place of Presentation
      US
    • Year and Date
      2008-11-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Chronic hypoxia increases bone marrow-derived endothelial cells of non-hematopoietic stem cell origin, as well as macrophages of hematopoietic stem cell origin, in pulmonary vascular. lesions in mice : differential roles of bone marrow-derived hematopoietic and non-hematopoietic stem cells in pulmonary hypertension2008

    • Author(s)
      Kato T, Sawada H, Maruyama J, Masuya M, Mityata E, Nakamura S, Ikeyama Y, Shimpo H, Maruyama K, Komada Y, Mitani Y.
    • Organizer
      American Heart Association
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Necrotic Core and Dense Calcium, not Fibrous, -Components contribute to an Increased Plaque Burden Associated with Localized Stenosis in Patients Long after Kawasaki Disease : Quantitative Gray Scale-andVirtual Histology-Intravascular Ultrasound Study2008

    • Author(s)
      Mitani Y, Ohashi H
    • Organizer
      American Heart Association
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] State of Art : Therapeutic advances inpulmonary hypertension 20082008

    • Author(s)
      三谷義英
    • Organizer
      第44回日本小児循環器学会総会
    • Place of Presentation
      郡山
    • Year and Date
      2008-07-02
    • Related Report
      2008 Final Research Report
  • [Presentation] マウス肺高血圧性血管病変における骨髄幹細胞の関与 : 間葉系幹細胞と血球系幹細胞の役割2008

    • Author(s)
      加藤太一(1)、三谷義英(2)、丸山一男(8)、新保秀人(9)、計10名
    • Organizer
      第44回日本小児循環器学会総会
    • Place of Presentation
      郡山市
    • Year and Date
      2008-07-02
    • Related Report
      2008 Final Research Report
  • [Presentation] ボセンタンの新たな肺高血圧抑制機序 : 骨髄移植肺高血圧マウスを用いた骨髄由来細胞動態への影響2008

    • Author(s)
      加藤太一(1)、三谷義英(2)、丸山一男(8)、新保秀人(9)、計10名
    • Organizer
      第44回日本小児循環器学会総会
    • Place of Presentation
      郡山市
    • Year and Date
      2008-07-02
    • Related Report
      2008 Final Research Report
  • [Presentation] 先天性心疾患の治療計画におけるSildenafil の有用性(第2報) : non-PH群での中期成績2008

    • Author(s)
      三谷義英(1)、大橋啓之(2)、新保秀人(6)、計7名
    • Organizer
      第44回日本小児循環器学会総会
    • Place of Presentation
      郡山市
    • Year and Date
      2008-07-02
    • Related Report
      2008 Final Research Report
  • [Presentation] State of Art : Therapeutic advances in pulmonary hypertension 20082008

    • Author(s)
      三谷義英
    • Organizer
      第44回日本小児循環器学会総会
    • Place of Presentation
      郡山
    • Year and Date
      2008-07-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肺高血圧-最近の考え方と治療2008

    • Author(s)
      三谷義英
    • Organizer
      第2回成人先天性心疾患セミナー
    • Place of Presentation
      東京
    • Year and Date
      2008-06-21
    • Related Report
      2008 Final Research Report
  • [Presentation] In Vivo Plaque Composition and Morphologyin Coronary Artery Lesions in theAdolescents and Young Adults Long afterKawasaki Disease : Lessons Learned fromVirtual Histology- IntravascularUltrasound Study2007

    • Author(s)
      Mitani Y(1)、Ohashi H(2)、計5名
    • Organizer
      American Heart Association
    • Place of Presentation
      Orland, US
    • Year and Date
      2007-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] In Vivo Plaque Composition and Morphology in Coronary Artery Lesions in the Adolescents and Young Adults Long after Kawasaki Disease:Lessons Learned from Virtual Histology-lntravascular Ultrasound Study2007

    • Author(s)
      Mitani Y, Ohashi H, et. al.
    • Organizer
      American Heart Association
    • Place of Presentation
      Orland, US
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 先天性心疾患の治療計画におけるSildenafilの有用性(第1報):non-PH群への応用2007

    • Author(s)
      三谷 義英, 他
    • Organizer
      日本小児循環器学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨髄由来細胞と造血幹細胞のマウス実験的肺高血圧への関与2007

    • Author(s)
      加藤 太一、三谷 義英, 他
    • Organizer
      日本小児循環器学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Glenn術後のFontan calldidateに合併した肺静脈閉塞の原因と予後2007

    • Author(s)
      大橋 啓之、三谷 義英, 他
    • Organizer
      日本小児循環器学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of Bosentan in the treatment of pulmonary vascular diseases associated with congenital heart disease2007

    • Author(s)
      Mitani Y
    • Organizer
      The 4th Scientific symposium for pulmonary hypertension
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-06-10
    • Related Report
      2007 Annual Research Report
  • [Book] 小児疾患診療のための病態生理-原発性肺高血圧2008

    • Author(s)
      三谷義英
    • Publisher
      東京医学社
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi