A study for the etiology of the metabolic syndrome in childhood focusing on hereditary obesity
| Project/Area Number |
19591207
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tottori University |
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Principal Investigator |
HANAKI Keiichi Tottori University, 医学部, 教授 (20238041)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAISHI Junichi 鳥取大学, 医学部附属病院, 講師 (90346354)
NAGATA Ikuo 鳥取大学, 医学部, 准教授 (50252846)
KANZAKI Susumu 鳥取大学, 医学部, 教授 (90224873)
KINOSHITA Tomoe 鳥取大学, 医学部附属病院, 助教 (80444636)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | メタボリックシンドローム / 小児肥満 / 遺伝性肥満 / アディポネクチン / 子宮内発育不全 / 糖尿病 / シグナル伝達 |
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| Research Abstract |
The aim of this study was to elucidate the mechanism by which the metabolic syndrome developed, especially in Alstroem syndrome, a hereditary obesity inevitably developing the metabolic syndrome. Several findings were obtained focusing on the insulin/IGF-1 action in the Alstroem syndrome, a relationship between SNPs for obesity-related genes and blood chemistry, and a relationship between high-molecular adiponectin and intra/extra uterine growth.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] San-in Asthma Research Group. Environmental tobacco smoke and its effect on the symptoms and medication in children with asthma2009
Author(s)
Yamasaki A, Hanaki K, Tomita K, Watanabe M, Hasagawa Y, Okazaki R, Igishi T, Horimukai K, Fukutani K, Sugimoto Y, Yamamoto M, Kato K, Ikeda T, Konishi T, Tokuyasu H, Yajima H, Sejima H, Isobe T, Shimizu E
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Journal Title
Int J Environ Health Res 19(2)
Pages: 97-108
Related Report
Peer Reviewed
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[Journal Article] Cytochrome P450 oxidoreductase deficiency: identification and characterization of biallelic mutations and genotype-phenotype correlations in 35 Japanese patients2009
Author(s)
Fukami M, Nishimura G, Homma K, Nagai T, Hanaki K, Uematsu A, Ishii T, Numakura C, Sawada H, Nakacho M, Kowase T, Motomura K, Haruna H, Nakamura M, Ohishi A, Adachi M, Tajima T, Hasegawa Y, Hasegawa T, Horikawa R, Fujieda K, Ogata T.
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Journal Title
J Clin Endocrinol Metab 94(5)
Pages: 1723-31
Related Report
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[Journal Article] Mental retardation, spasticity, basal ganglia calcification, cerebral white matter lesions, multiple endocrine defects, telangiectasia and atrophic skin: a new syndrome?2008
Author(s)
Saito Y, Toyoshima M, Oka A, Zhuo L, Moriwaki S, Yamamoto O, Kanzaki S, Hanaki K, Ninomiya H, Nanba E, Kondo A, Maegaki Y, Ohno K.
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Journal Title
Brain Dev 30(3)
Pages: 221-5
NAID
Related Report
Peer Reviewed
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[Journal Article] Lower brainstem dysfunction in an infant with persistent primitive trigeminal artery2007
Author(s)
Okanishi T, Saito Y, Miki S, Nagaishi J, Hanaki K, Tomita Y, Fukuda C, Fujii S, Fujiwara K, Kawamoto K, Hata F, Maegaki Y, Ohno K.
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Journal Title
Brain Dev 29(3)
Pages: 189-92
NAID
Related Report
Peer Reviewed
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