| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
One of the causes of dilated cardiomyopathy is reported the abnormality of around exon 1 of the dystrophin, which is cause of Duchenne muscular dystrophy. We investigated analysis of the onset mechanisms and the frequency in this study. One of two cases showed that mutation in the splice donor site of exon 1 of dystrophin but another case did not. In spite of abnormality of dystrophin, the non-muscle weakness is explained that dystrophin isoform compensated in a skeletal muscle.
We analyzed dystrophin regulation with DNA array, but the known pathway did not have shown.
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