Islet transplantation for youth onset I type diabetes Function chain of growth and reproduction

• Project/Area Number: 19591211
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Fukushima Medical University
• Principal Investigator: ISE Kazuya Fukushima Medical University, 医学部, 助教 (90363746)
• Co-Investigator(Kenkyū-buntansha): MATSUYAMA Shinichi 福島県立医科大学, 医学部, 研究員 (90381384) ; GOTOH Mitsukazu 福島県立医科大学, 医学部, 教授 (50162160)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 小児内分泌学 / 膵島移植 / 小児

Research Abstract

諸家の報告と同様に、個体の成長とともに膵島細胞の容量は増加していることが確認された。増殖因子のない条件での膵島と骨髄細胞の混合培養では、骨髄細胞からのインスリン分泌は確認されなかった。

Research Products

• [Journal Article] Mitomycin-C treatment followed by culture produces long-term survival of isletxenografts in a rat-to mouse model (2008)
  • Author(s): Gunji T, Saito T, Sato Y, Matsuyama S, Ise K, Kimura T, Anazawa T, Gotoh M
  • Journal Title: Cell Transplant 17(6) Pages: 619-629
  • Peer Reviewed
• [Journal Article] Traffic of infused bone marrow cells after genetically-labeled syngeneic bone marrow transplantation following lethal irradiation in mice (2008)
  • Author(s): Satoh A, Saito T, Sato Y, Tsuchiya T, Kenjo A, Kimura T, Kanno R, Suzuki H, Kogure M, Hoshino Y, Gotoh M
  • Journal Title: Fukushima J Med Sci. 54(1) Pages: 11-24
  • NAID: 10030915749
  • Peer Reviewed
• [Journal Article] Mitomycin-C treatment followed by culture produces longterm survival of islet xenografts in a rat to mouse model. (2008)
  • Author(s): Gunji T
  • Journal Title: Cell Transplantation 17(6) Pages: 619-629
  • Peer Reviewed
• [Journal Article] Traffic of infused bone marrow cells after genetically labeled syngeneic bone marrow transplantation following lethal irradiation in mice. (2008)
  • Author(s): Satoh A
  • Journal Title: Fukushima Journal of Medical Science 54(1) Pages: 11-14
  • Peer Reviewed
• [Journal Article] ミゾリビンの異種移植における生着延長効果 (2007)
  • Author(s): 山下方俊、斎藤拓朗、佐藤佳宏、伊勢一哉、後藤満一
  • Journal Title: 今日の移植 20(3) Pages: 248-251
  • Peer Reviewed
• [Presentation] Adenine nucleotide levels in closed automated enzymatic digestion system for porcine islet isolation : a new aspect of dilution timing (2008)
  • Author(s): Oshibe I, Sato Y, Saito T, Sato J, Kimura T, Kenjo A, Saito T, Gotoh M
  • Organizer: The 7^<th> Korea-Japan Transplantation Forum
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-10-11
• [Presentation] Morphological and molecular-biological assessment of rat islets pretreated with Mitomycin-C (MMC) before transplantation (2008)
  • Author(s): Saito Takaharu, Saito Takuro, Sato Y, Ise K, Gunji T, Oshibe I,(Yamamoto M, Waguri S), Gotoh M
  • Organizer: The 7^<th> Korea-Japan Transplantation Forum
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-10-11
• [Presentation] Morphological and molecular biological assessment of ratislets pretreated with Mitomycin-C (MMC) before transplantation. (2008)
  • Author(s): Saito T
  • Organizer: The 7^<th> Korea-Japan Transplantation
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-10-11
• [Presentation] Adenine nucleotide levels in closed automated enzymatic digestion system for porcine islet isolation : a new aspect of dilution timing. (2008)
  • Author(s): Oshibe l
  • Organizer: The 7^<th> Korea-Japan Transplantation
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-10-11
• [Presentation] Higly toxic environment to isolated islets during collagenase overdigention. (2008)
  • Author(s): Tsukada M
  • Organizer: The 22th International Congress of the Transplantation Society
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2008-08-13
• [Presentation] Highly Toxic Environment to Isolated Islets during Collagenase Overdigestion (2008)
  • Author(s): Tsukada M, Gotoh M, Saito T, Ise K, Kenjo A, Kimura T, Sato Y, Anazawa T, Suzuki S
  • Organizer: The 22^<th> International Congress of The Transplantation Society
  • Place of Presentation: Sydney, Australia
• [Presentation] Rapid assessment of potential insulin secretory capacity of islets using a newly developed ATP bioluminescence assay (2007)
  • Author(s): Ishii S, Saito T, Sato Y, Ise K, Kenjo A, Kimura T, Anazawa T, Terashima M, Suzuki S, Gotoh M
  • Organizer: The American Transplant Congress
  • Place of Presentation: San Francisco,USA