Experimental studies on the regenerative medicine aimed at vascular endothelial dysfunction in Kawasaki disease

• Project/Area Number: 19591214
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: OZAWA Seiichiro Kyoto Prefectural University of Medicine, 医学研究科, 助教 (40405246)
• Co-Investigator(Kenkyū-buntansha): HAMAOKA Kenji 京都府立医科大学, 医学研究科, 教授 (60189602)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 川崎病 / 血管炎 / 血管内皮障害 / HMG-CoA還元酵素阻害剤 / 血管炎動物モデル / スタチン / 小児科学

Research Abstract

離乳早期日本白色系家兎を用い血管炎モデルを作成し、HMG-CoA還元酵素阻害剤(スタチン)の抗炎症効果を検討した。結果として、血管炎モデルでは、内膜の剥離を伴う全層性の炎症性変化、中膜を中心とする浮腫状血管壁肥厚、内弾性板の破壊などを伴う血管炎が出現し、血管炎惹起1ヶ月後も継続した。一方、スタチン投与群において、全層性の炎症反応は軽減し、内膜の限局的炎症性変化、軽度の血管壁肥厚を中心とする変化に留まる傾向が見られた。以上の結果より、スタチンの血管炎に対する抗炎症効果が認められた。

Research Products

• [Journal Article] Anti-inflammatory effects of HMG-CoA Reductase Inhibitors (statins) on acute coronary arteritis in a rabbit Model of Kawasaki disease (2007)
  • Author(s): Ozawa S、Hamaoka K
  • Journal Title: Cardiology in the Young 17 Pages: 76-76
  • Peer Reviewed
• [Presentation] 川崎病血管炎に対するHMG-CoA還元酵素阻害剤(スタチン)の抗炎症効果に関する実験的検討 (2008)
  • Author(s): 小澤誠一郎、浜岡建城
  • Organizer: 第44回小児循環器学会総会
  • Place of Presentation: 福島県郡山
  • Year and Date: 2008-07-16
• [Presentation] Investigating the serial process of the histopathological features on acute coronary arteritis in a rabbit model of Kawasaki disease (2008)
  • Author(s): Ozawa S、Hamaoka K
  • Organizer: 9th International Kawasaki Disease Symposium
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2008-04-18
• [Presentation] Investigating the serial process of the histopathological features on acute coronary arteritis in a rabbit model of Kawasaki disease (2008)
  • Author(s): Ozawa S
  • Organizer: 9^<th> International Kawasaki Disease Symposium
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2008-04-18
• [Presentation] Anti-inflammatory effects of HMG-CoA Reductase Inhibitors (statins) on acute coronary arteritis in a rabbit Model of Kawasaki disease (2007)
  • Author(s): Ozawa S、Hamaoka K
  • Organizer: the 29th European Society of Cardiology Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2007-09-02
• [Presentation] HMG-CoA Reductase Inhibitors (statins) are Effective for Prevention of Acute Coronary Artery Injury in a Rabbit Model of Kawasaki disease (2007)
  • Author(s): Ozawa S、Hamaoka K
  • Organizer: the 42th Annual Meeting of the Association for European Pediatric Cardiology
  • Place of Presentation: Warsaw, Poland
  • Year and Date: 2007-05-18
• [Presentation] ANTI-INFLAMMATORY EFFECTS OF HMG-COA REDUCTASE INHIBITOR(STATIN)ON ACUTE CORONARY ARTERITIS IN A RABBIT MODEL OF KAWASAKI DISEASE (2007)
  • Author(s): Sei-ichiro Ozawa
  • Organizer: The ESC Congress 2007
  • Place of Presentation: Vienna, Austria
• [Remarks] ホームページ
  • URL: http://koto8.kpu-m.ac.jp/~pedchd/rs-JSPCCS2008.html
• [Remarks]
  • URL: http://kotoS.kpu-m.ac.jp/~pedchd/rs-JSPCCS2008.htm