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Experimental studies on the regenerative medicine aimed at vascular endothelial dysfunction in Kawasaki disease

Research Project

Project/Area Number 19591214
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

OZAWA Seiichiro  Kyoto Prefectural University of Medicine, 医学研究科, 助教 (40405246)

Co-Investigator(Kenkyū-buntansha) HAMAOKA Kenji  京都府立医科大学, 医学研究科, 教授 (60189602)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords川崎病 / 血管炎 / 血管内皮障害 / HMG-CoA還元酵素阻害剤 / 血管炎動物モデル / スタチン / 小児科学
Research Abstract

離乳早期日本白色系家兎を用い血管炎モデルを作成し、HMG-CoA還元酵素阻害剤(スタチン)の抗炎症効果を検討した。結果として、血管炎モデルでは、内膜の剥離を伴う全層性の炎症性変化、中膜を中心とする浮腫状血管壁肥厚、内弾性板の破壊などを伴う血管炎が出現し、血管炎惹起1ヶ月後も継続した。一方、スタチン投与群において、全層性の炎症反応は軽減し、内膜の限局的炎症性変化、軽度の血管壁肥厚を中心とする変化に留まる傾向が見られた。以上の結果より、スタチンの血管炎に対する抗炎症効果が認められた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2008 2007 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Anti-inflammatory effects of HMG-CoA Reductase Inhibitors (statins) on acute coronary arteritis in a rabbit Model of Kawasaki disease2007

    • Author(s)
      Ozawa S、Hamaoka K
    • Journal Title

      Cardiology in the Young 17

      Pages: 76-76

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 川崎病血管炎に対するHMG-CoA還元酵素阻害剤(スタチン)の抗炎症効果に関する実験的検討2008

    • Author(s)
      小澤誠一郎、浜岡建城
    • Organizer
      第44回小児循環器学会総会
    • Place of Presentation
      福島県郡山
    • Year and Date
      2008-07-16
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Investigating the serial process of the histopathological features on acute coronary arteritis in a rabbit model of Kawasaki disease2008

    • Author(s)
      Ozawa S、Hamaoka K
    • Organizer
      9th International Kawasaki Disease Symposium
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-04-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Investigating the serial process of the histopathological features on acute coronary arteritis in a rabbit model of Kawasaki disease2008

    • Author(s)
      Ozawa S
    • Organizer
      9^<th> International Kawasaki Disease Symposium
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-04-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Anti-inflammatory effects of HMG-CoA Reductase Inhibitors (statins) on acute coronary arteritis in a rabbit Model of Kawasaki disease2007

    • Author(s)
      Ozawa S、Hamaoka K
    • Organizer
      the 29th European Society of Cardiology Congress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2007-09-02
    • Related Report
      2008 Final Research Report
  • [Presentation] HMG-CoA Reductase Inhibitors (statins) are Effective for Prevention of Acute Coronary Artery Injury in a Rabbit Model of Kawasaki disease2007

    • Author(s)
      Ozawa S、Hamaoka K
    • Organizer
      the 42th Annual Meeting of the Association for European Pediatric Cardiology
    • Place of Presentation
      Warsaw, Poland
    • Year and Date
      2007-05-18
    • Related Report
      2008 Final Research Report
  • [Presentation] ANTI-INFLAMMATORY EFFECTS OF HMG-COA REDUCTASE INHIBITOR(STATIN)ON ACUTE CORONARY ARTERITIS IN A RABBIT MODEL OF KAWASAKI DISEASE2007

    • Author(s)
      Sei-ichiro Ozawa
    • Organizer
      The ESC Congress 2007
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://koto8.kpu-m.ac.jp/~pedchd/rs-JSPCCS2008.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://kotoS.kpu-m.ac.jp/~pedchd/rs-JSPCCS2008.htm

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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