The regulatory mechanisms via astrocytes on neuronal injury after status epileptics
| Project/Area Number |
19591224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
TAKEMIYA Takako Tokyo Women's Medical University, 医学部, 講師 (70297547)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIURA Hiroko (財)東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (40162870)
前原 通代 東京女子医科大学, 大学病院, 主任検査技師 (90398800)
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| Co-Investigator(Renkei-kenkyūsha) |
MAEHARA Michiyo 東京女子医科大学, 大学病院, 主任検査技師 (90398800)
TAKEUCHI Chisen 東京女子医科大学, 医学部, 非常勤講師 (70333094)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 小児神経学 / てんかん / プロスタグランジンE_2 / 血管内皮細胞 / アストロサイト / 神経細胞傷害 / 誘導型PGE_<+2>合成酵素mPGES-1 / プロスタグランジンE2 / EPレセプター / カイニン酸 / 誘導型PGE_2合成酵素mPGES-1 / 神経細胞障害 |
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| Research Abstract |
Kainic acid (KA) causes seizures and hippocampal neuron damage in the brain. In this study we found that KA also induces endothelial microsomal prostaglandin E synthase-1 (mPGES-1) and prostaglandin E_2 (PGE_2) receptor EP3 on astrocytes. The PGE_2 produced by mPGES-1 stimulates the activation of EP3 on astrocytes, therefore causes the increase in intracellular Ca^<2+> in astrocytes and glutamate release, leading to the neuronal injury.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Activity-Induced Protocadherin Arcadlin Regulates Dendritic Spine Number by Triggering N-Cadherin Endocytosis via TAO2beta and p38 MAP Kinases.2007
Author(s)
Yasuda S, Tanaka H, Sugiura H, Okamura K, Sakaguchi T, Tran U, Takemiya T, Mizoguchi A, Yagita Y, Sakurai T, De Robertis EM, Yamagata K.
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Mechanism of dendritic spine abnormality in tuberous sclerosis.2008
Author(s)
Sugiura, H., Takigami, S., Yasuda, S., Yoshimura, Y., Takemiya, T., Yamauchi T., Hino O., Yamagata, K.
Organizer
第51回日本神経化学会大会
Place of Presentation
富山
Year and Date
2008-09-12
Related Report
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[Presentation] Endothelial mPGES-1 regulates Ca^<2+>-dependent glutamate release from astrocyte via EP3.2008
Author(s)
Takemiya, T., Matsumura, K., Sugiura, H., Yasuda, S., Uematsu, S., Akira, S., Yamagata, K.
Organizer
第51回日本神経化学会大会
Place of Presentation
富山
Year and Date
2008-09-11
Related Report
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