Lymphangiogenesis in acute Kawasaki disease

• Project/Area Number: 19591226
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: TERAI Masaru Tokyo Women's Medical University, 医学部, 教授 (80207472)
• Co-Investigator(Kenkyū-buntansha): YASUKAWA Kumi 千葉大学, 医学部附属病院, 助教 (10375769)
• Research Collaborator: EBATA Ryota 千葉大学, 大学院生
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 川崎病 / リンパ管新生 / VEGF-D

Research Abstract

川崎病において、修復に関与するリンパ系の再構築過程を明らかにし、川崎病重症例の治療に役立てることを目的とした。リンパ管新生因子VEGF-D は、血液中、浸潤細胞や心臓の組織、血管において産生が増加し、この蛋白の受容体はリンパ管に発現し、組織学的にもリンパ管が新たに新生する所見が得られた。TNF で処理すると、VEGF-D の産生が抑制されることが実験的に証明された。VEGF-D が川崎病血管炎の修復機転に大きな役割をしていることが示唆された。

Research Products

• [Journal Article] Elevated granulocyte colony-stimulating factor levels predict treatment failure in patients with Kawasaki disease (2008)
  • Author(s): Abe J, Ebata R, Jibiki T, Yasukawa K, Saito H, Terai M
  • Journal Title: J Allergy Clin Immunol 122 Pages: 1008-1013
  • Peer Reviewed
• [Journal Article] Treatment of Kawasaki disease - perspective (2008)
  • Author(s): Hamada H, Terai M
  • Journal Title: Nippon Rinsho. 2008 Feb(Review. Japanese) 66(2) Pages: 360-4
• [Journal Article] 小児科診療 診断と治療社 (2008)
  • Author(s): 寺井勝
  • Journal Title: 川崎病. 「小児科とサイトカイン」 71 Pages: 2191-2196
• [Journal Article] 小児内科増刊号 (2008)
  • Author(s): 寺井勝
  • Journal Title: 川崎病 40巻 Pages: 1445-1449
• [Journal Article] Elevated granulocyte colony-stimulating factor levels predict treatment failure in patients with Kawasaki disease. (2008)
  • Author(s): Abe J, et al
  • Journal Title: J Allergy Clin Immunol 122 Pages: 1008-1013
  • Peer Reviewed
• [Journal Article] : 川崎病 (2008)
  • Author(s): 寺井 勝
  • Journal Title: 小児内科増刊号 40 Pages: 1445-49
• [Journal Article] Treatment for Kawasaki disease-perspective (2008)
  • Author(s): Hamada H, Terai M
  • Journal Title: Nippon Rinsho 66 Pages: 360-364
  • NAID: 40015816185
• [Journal Article] Impairment of angiogenic activity in the serum from patients with coronary (2007)
  • Author(s): Higashi K, Terai M, Hamada H, Honda T, Kanazawa M, Kohno Y
  • Journal Title: aneurysms due to Kawasaki disease Circ J 71(7) Pages: 1052-9
  • Peer Reviewed
• [Journal Article] Impairment of angiogenic activity in the serum from patients with coronary aneurysms due to Kawasaki disease. (2007)
  • Author(s): Higashi K., et. al.
  • Journal Title: Circulation J 71 Pages: 1052-1059
  • Peer Reviewed
• [Presentation] Increased production of vascular endothelial growth factor-D and lymphangiogenesis in acute Kawasaki disease (2008)
  • Author(s): Ebata R, Yasukawa K, Hamada H, Higashi K, Abe J, Terai M
  • Organizer: 9th International Kawasaki Disease Symposium
  • Place of Presentation: 台湾
  • Year and Date: 2008-04-11
• [Presentation] Increased production of vascular endothelial growth factor-D and lympangiogenesis in acute Kawasaki disease. (2008)
  • Author(s): Ebata R, Yasukawa K, Hamad a H, Higashi K, Abe J, Terai M
  • Organizer: 9th International Kawasaki Disease Symposium
  • Place of Presentation: Taipei
  • Year and Date: 2008-04-11
• [Presentation] 川崎病巨大冠動脈瘤の検討-第19回川崎病全国調査から- (2008)
  • Author(s): 安川久美, 東 浩二, 寺井勝, 上原里程, 屋代真弓, 中村好一, 柳川洋
  • Organizer: 第27回日本川崎病研究会
  • Place of Presentation: 札幌