Evaluation of the function and response mechanism in vascular endotherial cell and smooth muscle cell caused by vasculitis, and its treatment

• Project/Area Number: 19591227
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nippon Medical School
• Principal Investigator: OGAWA Hunichi Nippon Medical School, 医学部, 教授 (50194436)
• Co-Investigator(Kenkyū-buntansha): KATSUBE Yasuhiro 日本医科大学, 医学部, 准教授 (20246523) ; RYUJI Fukazawa 日本医科大学, 医学部, 講師 (80277566)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 血管炎 / 血管虚血 / 血管虚血細胞 / 血管内皮機能 / 血管平滑筋 / 血管内皮細胞 / 血管平滑筋細胞

Research Abstract

血管炎症後に長時間虚血を誘発した細胞は、炎症のみの細胞、正常細胞に比し、細胞膜およびミトコンドリアのKATPチャンネル電流密度は有意に低下し、血管の虚血により血管平滑筋細胞障害が惹起されることが示唆された。さらに、分子生物学的検討においても血管炎後に血管虚血を誘発し、それが長期間に亘ることにより血管内皮細胞機能は有意に低下することが推察された。

Research Products

• [Journal Article] Long-Term Prognosis of Patients with Kawasaki Disease : At Risk for Future Atherosclerosis? (2009)
  • Author(s): Ryuji Fukazawa, Shunichi Ogawa.
  • Journal Title: J Nippon Med Sch. (in print)
  • NAID: 130004146983
  • Peer Reviewed
• [Journal Article] Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence. (2007)
  • Author(s): Ryuji Fukazawa R, Ei Ikegam, Miki Watanabe, Miharu Hajikano, Mitsuhiro Kamisago, Yasuhiro Katsube, Hitoshi Yamauchi, Masami Ochi, Shunichi Ogawa.
  • Journal Title: Circ J. 71(5) Pages: 709-15
  • NAID: 110006273607
  • Peer Reviewed
• [Presentation] Inositol 1, 4, 5-Triphosphate 3-Kinase C polymorphism associated with disease severity and coronary artery lesions in Kawasaki disease. (2009)
  • Author(s): Ryuji Fukazawa, Shunichi Ogawa.
  • Organizer: The 73nd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] Inositol 1, 4, 5-Triphosphate 3-Kinase C polymorphism associated with disease severity and coronary artery lesions in Kawasaki disease (2009)
  • Author(s): Ryuji Fukazawa, Shunichi Ogawa, et al.
  • Organizer: The 73nd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] A new marker for vasculitis (2008)
  • Author(s): Yasuhiro Katsube, Shunichi Ogawa.
  • Organizer: pentraxin 3, is elevated in patients with Kawasaki disease. European Society of Cardiology Congress 2008
  • Place of Presentation: Munich, Germany
  • Year and Date: 2008-09-02
• [Presentation] A new marker for vasculitis, pentraxin 3, is elevated in patients with Kawasaki disease (2008)
  • Author(s): Yasuhiro Katsube, Shunichi Ogawa, et al.
  • Organizer: European Society of Cardiology Congress 2008
  • Place of Presentation: Munich, Germany
  • Year and Date: 2008-09-02
• [Presentation] Estimation of silent myocardial ischemia caused by coronary micro circulatory disturbance after Kawasaki disease. (2008)
  • Author(s): Shunichi Ogawa, Ryuji Fukazawa, Mitsuhiro Kamisago, Ei Ikegami, Miki Watanabe, Miharu Hajikano, Masanori Abe, Yasuhiro Katsube.
  • Organizer: European Society of Cardiology Congress 2008
  • Place of Presentation: Munich, Germany
  • Year and Date: 2008-09-01
• [Presentation] Estimation of silent myocardial ischemia caused by coronary micro circulatory disturbance after Kawasaki disease (2008)
  • Author(s): Shunichi Ogawa, et al.
  • Organizer: European Society of Cardiology Congress 2008
  • Place of Presentation: Munich, Germany
  • Year and Date: 2008-09-01