Scientific research for developing a novel immunotherapy targetinginteraction of CD26 and its ligand

• Project/Area Number: 19591240
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: The University of Tokyo
• Principal Investigator: OHNUMA Kei The University of Tokyo, 医科学研究所, 助教 (10396872)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: T細胞 / 共刺激 / CD26 / caveolin-1 / 移植片対宿主病 / 臍帯血 / CD28 / CaveoIin-1 / GVHD

Research Abstract

造血幹細胞移植における拒絶反応や移植片対宿主病(GVHD)などの免疫異常症に対する治療の最終目標は、感染症に対する生体防御反応を妨げることなく異常炎症反応を特異的に抑制することである。そこで、われわれが発見した新規T細胞共刺激系CD26-カベオリン経路の詳細な解明を行い、日和見感染症などをもたらす免疫不全状態を避けつつ同種メモリー応答依存性T細胞の異常活性化状態をコントロールしうる新規抗原特異的免疫寛容誘導療法につながる知見を得ることができた。

Research Products

• [Journal Article] An adult case ofHenoch-Schonlein (2009)
  • Author(s): Ohnuma K, Hosono O, Kawasaki H,Yoshikawa N, Katayose T, Oyaizu N, TanakaH, Morimoto C.
  • Journal Title: purpura complicatingcommon peroneal nerve mononeuropathy.Modern Rheumatology 19 Pages: 73-79
• [Journal Article] An adult case of Henoch?SchOnlein purpura complicating common peroneal nerve mononeuropathy. (2009)
  • Author(s): Ohnuma K, Hosono O, et al.
  • Journal Title: Modern Rheumatology 19 Pages: 73-79
  • NAID: 10025112125
  • Peer Reviewed
• [Journal Article] Comparative studyof regulatory T cell function of humanCD25+CD4+ T cells from thymocytes, cordblood, and adult peripheral blood (2008)
  • Author(s): Fujimaki W, Takahasi N, Ohnuma K, Nagatsu M, Kurosawa H, Yoshida S, Dang NH,Uchiyama T, Morimoto C.
  • Journal Title: Clinical and Developmental Immunology 2008 Pages: 205859-205859
  • Peer Reviewed
• [Journal Article] Revisiting an old acquaintance : CD26 and its (2008)
  • Author(s): Ohnuma K, Dang NH, Morimoto C.
  • Journal Title: molecular mechanisms in T cell function. Trends in Immunology 29 Pages: 295-301
  • Peer Reviewed
• [Journal Article] Role of CD26/dipeptidyl peptidase IV in human T (2008)
  • Author(s): Ohnuma K, Takahashi N, Yamochi T,Hosono O, Dang NH, Morimoto C.
  • Journal Title: cell activation and function. Frontiers inBiosciences 13 Pages: 2299-2310
  • Peer Reviewed
• [Journal Article] The role of CD26/dipeptidyl peptidase IV in cancer (2008)
  • Author(s): Harve PA, Abe M, Urasaki Y, Ohnuma K, Morimoto C, Dang NH.
  • Journal Title: Frontiers in Biosciences 13 Pages: 1634-1645
  • Peer Reviewed
• [Journal Article] SSA/Ro52 autoantigen interacts with Dcp2 to enhance (2008)
  • Author(s): Yamochi T, Ohnuma K, Hosono O, TanakaH, Kanai Y, Morimoto C.
  • Journal Title: its decapping activity. Biochem Biophys Res Commun 370(1) Pages: 195-199
  • Peer Reviewed
• [Journal Article] Comparative study of regulatory T cell function of human CD25+CD4+ T cells from thymocytes, cord blood, and adult peripheral blood. (2008)
  • Author(s): Fujimaki W, Ohnuma K, et al.
  • Journal Title: Clinical and Developmental Immunology 2008 Pages: 305859-305859
  • Peer Reviewed
• [Journal Article] Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function. (2008)
  • Author(s): Ohnuma K, Dang NH, et al.
  • Journal Title: Trends in Immunology 29 Pages: 295-301
  • Peer Reviewed
• [Journal Article] Role of CD26/dipeptidyl peptidase IV in human T cell activation and function. (2008)
  • Author(s): Ohnuma K, Takahashi N, et. al.
  • Journal Title: Frontiers in Biosciences 13 Pages: 2299-2310
  • Peer Reviewed
• [Journal Article] The role of CD26/dipeptidyl peptidase IV in cancer (2008)
  • Author(s): Harve PA, Ohnuma K, et. al.
  • Journal Title: Frontiers in Biosciences 13 Pages: 2299-2310
  • Peer Reviewed
• [Journal Article] Humanized anti-CD26 monoclonal antibody as a treatment for malignant (2007)
  • Author(s): Inamoto T, Yamada T, Ohnuma K, Kina S,Takahashi N, Yamochi T, Inamoto S, KatsuokaY, Hosono O, Tanaka H, Dang NH, and Morimoto C.
  • Journal Title: mesothelioma tumors. Clinical Cancer Research 13 Pages: 4191-4200
  • Peer Reviewed
• [Journal Article] Caveolin-1 triggers T-cell activation via (2007)
  • Author(s): Ohnuma K, Uchiyama M, Yamochi T, Nishibashi K, Hosono O, Takahashi N, Kina S, Tanaka H, Lin X, Dang NH, Morimoto C.
  • Journal Title: CD26 in association with CARMA1. J BiolChem 282(13) Pages: 10117-31
  • Peer Reviewed
• [Journal Article] Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans (2007)
  • Author(s): Ohnuma-Ishikawa K, Morio T, Yamada T, Sugawara Y, Ono M, Nagasawa M, Yasuda A, Morimoto C, Ohnuma K, Dang NH, Hosoi H, Verdin E, Mizutani S.
  • Journal Title: retinoic acid-sensitive and -resistant cancer cells. Cancer Res 67(3) Pages: 1019-29
  • Peer Reviewed
• [Journal Article] Humanized anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors (2007)
  • Author(s): Inamoto T, Ohnuma K, et. al.
  • Journal Title: Clinical Cancer Research 13 Pages: 4191-4200
  • Peer Reviewed
• [Presentation] `ヒト型抗CD26モノクローナル抗体による移植片対宿主病の治療法の開発 (2008)
  • Author(s): 大沼圭、山田健人、高橋望、遠藤裕子、細野治、森本幾夫
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2008-10-12
• [Presentation] ヒト型抗CD26モノローナル抗体による移植片対宿主病の治療法の開発 (2008)
  • Author(s): 大沼圭他
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2008-10-12
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/cimmuno/index.html
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/cimmuno/index.html
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/cimmuno/index.html