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Impact of susteined expression of phox2b gene on the differentiation of neuroblastoma

Research Project

Project/Area Number 19591262
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

IEHARA Tomoko  Kyoto Prefectural University of Medicine, 医学研究科, 講師 (20285266)

Co-Investigator(Kenkyū-buntansha) HOSOI Hajime  京都府立医科大学, 医学研究科, 教授 (20238744)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords神経芽腫 / phox2b / ASCL1 / Notch / γsecretase / 分化誘導
Research Abstract

神経芽腫(NB)の分化障害の原因として、phox2b、ASCL1遺伝子の高発現維持とそれによるDelta-Notch経路の恒常的な活性化の可能性を明らかにした。また、Notch阻害剤の神経芽腫に対する新たな分子標的療法の可能性について明らかにした。本研究を発展させ、phox2b高発現維持のメカニズム解明について検討を進めることにより、神経芽腫の分化障害、自然退縮のメカニズム、新たな分化誘導療法に対するアプローチを与えることが可能になると期待される。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (40 results)

All 2008 2007

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (25 results)

  • [Journal Article] Circulating methylated-DCR2 gene in serum as an indicator of prognosis and therapeutic efficacy in patients with MYCN nonamplified neuroblastoma2008

    • Author(s)
      Yagyu S, Iehara T, et.al.
    • Journal Title

      Clin Cancer Res 14

      Pages: 7011-7019

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The International Neuroblastoma Risk Group (INRG) Classification System2008

    • Author(s)
      Cohn SL, Iehara T, et.al.
    • Journal Title

      J Clin Oncol 27

      Pages: 289-297

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of screening for neuroblastoma at 6 months of age : a retrospective population-based cohort study2008

    • Author(s)
      Hiyama E, Iehara T, et.al.
    • Journal Title

      Lancet 371(9619)

      Pages: 1173-1180

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low-dose protracted irinotecan as a palliative chemotherapy for advanced neuroblastoma2008

    • Author(s)
      Osone S, Iehara T, et.al.
    • Journal Title

      J Pediatr Hematol Oncol 30

      Pages: 853-856

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trastuzumab Activates Allogeneic or Autologous Antibody-Dependent Cellular Cytotoxicity against Malignant Rhabdoid Tumor Cells and Interleukin-2 Augments the Cytotoxicity2008

    • Author(s)
      Katsumi Y, Tsuchiya K, Iehara T, Hosoi H, et.al.
    • Journal Title

      Clin Cancer Res 14

      Pages: 1192-1199

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma2008

    • Author(s)
      Kikuchi K, Tsuchiya K, Iehara T, Hosoi H, et.al.
    • Journal Title

      Biochem Biophys Res Commun 365

      Pages: 568-574

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Late appearance of a Philadelphia chromosome in a patient with. therapy-related acute myeloid leukemia and high expression of EVI12008

    • Author(s)
      Yagyu S, Iehara T, Hosoi H, et.al.
    • Journal Title

      Cancer Genetics and Cytogenetics 182(2)

      Pages: 115-20

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating methylated-DCR2 gene in serum as an indicator of prognosis and therapeutic efficacy in patients with MYCN nonamplified neuroblastoma2008

    • Author(s)
      Yagyu S, Iehara T, et al
    • Journal Title

      Clin Cancer Res. 14(21)

      Pages: 7011-7019

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of screening for neuroblastoma at 6 months of age : a retrospective population-based cohort study.2008

    • Author(s)
      Hiyama E, Iehara T, et al
    • Journal Title

      Lancet. Apr 5 ; 371(9619)

      Pages: 1173-1180

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-dose protracted irinotecan as a palliative chemotherapy for advanced neuroblastoma.2008

    • Author(s)
      Osone S, Iehara T, et al
    • Journal Title

      J Pediatr Hematol Oncol. 30(11)

      Pages: 853-856

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma.2008

    • Author(s)
      Kikuchi K, Iehara T, et al.
    • Journal Title

      Biochem Biophys Res Commun. 365(3)

      Pages: 568-574

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trastuzumab Activates Allogeneic or Autologous Antibody-Dependent Cellular Cytotoxicity against Malignant Rhabdoid Tum or Cells and Interleukin-2 Augments the Cytotoxicity.2008

    • Author(s)
      Katsumi Y, Iehara T, et al.
    • Journal Title

      Clin Cancer Res. 14(4)

      Pages: 1192-1199

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Late appearance of a Philadelphia chromosome in a patient with therapy-related acute myeloid leukemia and high expression of EVI1.2008

    • Author(s)
      Yagyu S, Iehara T, et al.
    • Journal Title

      Cancer Genet Cytogenet. 15 ; 180(2)

      Pages: 115-20

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] .Induction of apoptosis by an inhibitor of EGFR in neuroblastoma cells.2007

    • Author(s)
      Tamura S, Iehara T,
    • Journal Title

      Biochem Biophys Res Commun. 22;358(1)

      Pages: 226-232

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経芽腫の組織学的、生物学的特性-年齢的因子との関連-2007

    • Author(s)
      浜崎 豊、家原知子
    • Journal Title

      小児がん 43

      Pages: 712-718

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Methylation Analysis of DCR2 gene Using Tumor and Serum DNA of Neuroblastoma Patients2008

    • Author(s)
      Shigeki Yagyu, Tomoko Iehara, Hajime Hosoi, et.al.
    • Organizer
      44th annual meeting of American Society of Clinical Oncology
    • Place of Presentation
      Chicago
    • Related Report
      2008 Final Research Report
  • [Presentation] MYCN Amplified Neuroblastoma in Infants : From The Japanese Infantile Neuroblastoma Cooperative Study2008

    • Author(s)
      T Iehara, H Hosoi, et.al.
    • Organizer
      Advances in Neuroblastoma Research 2008
    • Place of Presentation
      Japan Chiba
    • Related Report
      2008 Final Research Report
  • [Presentation] Methylation Analysis of DCR2 gene Using Tumor and Serum DNA of Neuroblastoma Patients2008

    • Author(s)
      Shigeki Yagyu, Tomoko Iehara, Hajime Hosoi, et.al.
    • Organizer
      Advances in Neuroblastoma Research 2008
    • Place of Presentation
      Japan Chiba
    • Related Report
      2008 Final Research Report
  • [Presentation] MYCN amplification contributes to dysfunction of the p53 pathway in neuroblastoma2008

    • Author(s)
      Shinichi Tamura, Tomoko Iehara, Hajime Hosoi, et.al.
    • Organizer
      Advances in Neuroblastoma Research 2008
    • Place of Presentation
      Japan Chiba
    • Related Report
      2008 Final Research Report
  • [Presentation] PD 0332991 Inhibits Cell Proliferation And Induces G1Cell Cycle Arrest against Malignant Rhabdoid Tumor Cells Which Constitutively Express p16Ink4a at a Low Level2008

    • Author(s)
      Katsumi Y, Iehara T, Hajime Hosoi, et.al.
    • Organizer
      40th International Society of Pediatric Oncology
    • Place of Presentation
      Berlin, German
    • Related Report
      2008 Final Research Report
  • [Presentation] EVALUATION OF PROGNOSIS AND EFFICACY OF THERAPY FOR NEUROBLASTOMA PATIENTS BY QUANTIFICATION OF METHYLATED DCR2 GENE PROMOTER IN SERUM DNA2008

    • Author(s)
      Shigeki Yagyu, Tomoko Iehara, Hajime Hosoi, et.al.
    • Organizer
      40th International Society of Pediatric Oncology
    • Place of Presentation
      Berlin, German
    • Related Report
      2008 Final Research Report
  • [Presentation] Detection of IGF2 and H19 imprinting abnormalities in rhabdomyosarcoma patients using tumor and serum DNA2008

    • Author(s)
      Ken Kikuchi, Tomoko Iehara, Hajime Hosoi
    • Organizer
      40th International Society of Pediatric Oncology
    • Place of Presentation
      Berlin, German
    • Related Report
      2008 Final Research Report
  • [Presentation] IS THE PROGNOSIS OF STAGE 4S NEUROBLASTOMA OF 12 MONTHS OLD AND OVER REALY EXCELENT?2008

    • Author(s)
      Tomoko Iehara, Hajime Hosoi, et.al.
    • Organizer
      40th International Society of Pediatric Oncology
    • Place of Presentation
      Berlin, German
    • Related Report
      2008 Final Research Report
  • [Presentation] 他神経芽腫患者の血清中遊離DNAを用いた11番染色体長腕欠失の検出2008

    • Author(s)
      柳生茂希, 家原知子
    • Organizer
      第24回日本小児がん学会学術集会
    • Place of Presentation
      千葉、幕張
    • Related Report
      2008 Final Research Report
  • [Presentation] 他過去20年間に樹立した神経芽腫細胞株の臨床・基礎研究への貢献2008

    • Author(s)
      杉本徹、家原知子
    • Organizer
      第24回日本小児がん学会学術集会
    • Place of Presentation
      千葉、幕張
    • Related Report
      2008 Final Research Report
  • [Presentation] 他小児がん治療ガイドラインおよび小児がん治療成績のインターネット配信実現に係る研究2008

    • Author(s)
      松山琴音、家原知子
    • Organizer
      第24回日本小児がん学会学術集会
    • Place of Presentation
      千葉、幕張
    • Related Report
      2008 Final Research Report
  • [Presentation] Methylation Analysis of DCR2 gene Using Tumor and Serum DNA of Neuroblastoma Patients.2008

    • Author(s)
      Shigeki Yagyu, Tomoko Iehara, et al.
    • Organizer
      44^<th> annual meeting of American Society of Clinical Oncology.
    • Place of Presentation
      Chicago, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] MYCN Amplified Neuroblastoma in Infants : From The Japanese Infantile Neuroblastoma Cooperative Study.2008

    • Author(s)
      Iehara T, et al.
    • Organizer
      Advances in Neuroblastoma Research 2008
    • Place of Presentation
      Chiba, JAPAN
    • Related Report
      2008 Annual Research Report
  • [Presentation] Methylation Analysis of DCR2 gene Using Tumor and Serum DNA of Neuroblastoma Patients.2008

    • Author(s)
      Shigeki Yagyu, Tomoko Iehara, et al.
    • Organizer
      Advances in Neuroblastoma Research 2008
    • Place of Presentation
      Chiba, JAPAN
    • Related Report
      2008 Annual Research Report
  • [Presentation] MYCN amplification contributes to dysfunction of the p53 pathway in neuroblastoma2008

    • Author(s)
      Shinichi Tamura, Tomoko Iehara, et al.
    • Organizer
      Advances in Neuroblastoma Research 2008
    • Place of Presentation
      Chiba, JAPAN
    • Related Report
      2008 Annual Research Report
  • [Presentation] A review of owr twenty-year experience with established neuroblastoma cell lines2008

    • Author(s)
      Sugimoto T, Iehara T, et al.
    • Organizer
      Advances in Neuroblastoma Research 2008
    • Place of Presentation
      Chiba, JAPAN
    • Related Report
      2008 Annual Research Report
  • [Presentation] Highly specific and sensitive risk prediction for appropriate therapeutic intensity to advanced neurobalstoma2008

    • Author(s)
      Tanaka T, Iehara T, et al
    • Organizer
      Advances in Neuroblastoma Research 2008
    • Place of Presentation
      Chiba, JAPAN
    • Related Report
      2008 Annual Research Report
  • [Presentation] Low-dose protracted irinotecan as a palliative chemotherapy for advanced neuroblastoma.2008

    • Author(s)
      Osone S, Iehara T, et al.
    • Organizer
      Advances in Neuroblastoma Research 2008
    • Place of Presentation
      Chiba, JAPAN
    • Related Report
      2008 Annual Research Report
  • [Presentation] Is the prognosis of stage 4s neuroblastoma of 12 months old and over really excellent?2008

    • Author(s)
      Iehara T, et al.
    • Organizer
      40^<th> International Society of Pediatric Oncology
    • Place of Presentation
      Berlin, German
    • Related Report
      2008 Annual Research Report
  • [Presentation] EVALUATION OF PROGNOSIS AND EFFICACY OF THERAPY FOR NEUROBLASTOMA PATIENTS BY QUANTIFICATI ON OF METHYLATED DCR2 GENE PROMOTER IN SERUM DNA.2008

    • Author(s)
      Yagyu S, Iehara T, et al
    • Organizer
      40^<th> International Society of Pediatric Oncology
    • Place of Presentation
      Berlin, German
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経芽腫患者の血清中遊離DNAを用いた11番染色体長腕欠失の検出2008

    • Author(s)
      柳生茂希, 家原知子, 他
    • Organizer
      第24回日本小児がん学会学術集会
    • Place of Presentation
      千葉、幕張
    • Related Report
      2008 Annual Research Report
  • [Presentation] 過去20年間に樹立した神経芽腫細胞株の臨床・基礎研究への貢献.2008

    • Author(s)
      杉本徹, 家原知子, 他
    • Organizer
      第24回日本小児がん学会学術集会
    • Place of Presentation
      千葉、幕張
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小児がん治療ガイドラインおよび小児がん治療成績のインターネット配信実現に係る研究2008

    • Author(s)
      松山琴音, 家原知子, 他
    • Organizer
      第24回日本小児がん学会学術集会
    • Place of Presentation
      千葉、幕張
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経芽腫におけるDCR2遺伝子異常メチル化の検出と、予後不良因子、微少残存病変マーカーとしての有用性2007

    • Author(s)
      柳生茂季、家原知子
    • Organizer
      第23回日本小児がん学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神経芽腫に対するgefitinibの抗腫瘍効果2007

    • Author(s)
      田村真一、家原知子
    • Organizer
      第110回日本小児科学会学術集会.
    • Place of Presentation
      京都
    • Year and Date
      2007-04-21
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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