Research and development of therapeutic antibodies against human rotavirus infection.

Research Project

Project/Area Number	19591266
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Pediatrics
Research Institution	Fujita Health University
Principal Investigator	MORIGUCHI Kyoko Fujita Health University, 医学部, 講師 (60298528)
Co-Investigator(Kenkyū-buntansha)	TANIGUCH Ikoki 藤田保健衛生大学, 医学部, 教授 (40094213)
Project Period (FY)	2007 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords	ヒト型ファージ抗体 / 交叉反応性 / ロタウイルス / ノロウイルス / ファージ抗体 / HRV / ヒト型抗体 / モノクローナル / HuNov / 小児感染症学 / 受動免疫 / 乳酸菌 / 中和 / ヒト型
Research Abstract	Expression system of human antibodies in Lactococcus lactise was established to be enable to produce the molecules persistently in intestine. We also tried to isolate anti-human norovirus antibodies, and 66 clones (42types) including2cross-reactive antibodies were isolated.

Report

(6 results)