Analyses of egg white specific T cell response and regulatory T cells in hen's egg allergic patients.
| Project/Area Number |
19591267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fujita Health University |
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Principal Investigator |
TSUGE Ikuya Fujita Health University, 医学部, 教授 (00231431)
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| Co-Investigator(Kenkyū-buntansha) |
URISU Atsuo 藤田保健衛生大学, 医学部, 教授 (20193972)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 鶏卵アレルギー / 特異的免疫療法 / 特異的T細胞応答 / TH1 / TH2バランス / 抑制性サイトカイン / 食物アレルギー / サイトカイン産生プロフィール / アレルゲン特異的T細胞 / 制御性T細胞 |
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| Research Abstract |
Food allergen specific T cells play a central role in both pathogenesis and tolerance induction of food allergy by regulating IgE production and allergic effecter cells such as eosinophils and mast cells. In this project, we analyzed changes of egg white specific T cell responses during specific immunotherapy for hen's egg allergy. The results showed an increase of suppressive cytokine TGF-β and decreases of Th1/Th2 cytokines as the course of immunotherapy progressed. These finding might contribute to further improvement of specific immunotherapy.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome.2009
Author(s)
Minegishi Y, Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Karasuyama H.
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Journal Title
J Exp Med. 206
Pages: 1291-301
Related Report
Peer Reviewed
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[Journal Article] Developmental changes of FOXP3-expressing CD4+CD25+ regulatory T cells and their impairment in patients with FOXP3 gene mutations.2007
Author(s)
Fuchizawa T, Adachi Y, Ito Y, Higashiyama H, Kanegane H, Futatani T, Kobayashi I, Kamachi Y, Sakamoto T, Tsuge I, Tanaka H, Banham AH, Ochs HD, Miyawaki T.
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Journal Title
Clin Immunol. 125
Pages: 237-46
Related Report
Peer Reviewed
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[Journal Article] Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.2007
Author(s)
Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, Kawamura N, Ariga T, Pasic S, Stojkovic O, Metin A, Karasuyama H.
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Journal Title
Nature 448
Pages: 1058-62
Related Report
Peer Reviewed
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