Development of food antigens for oral immunotherapy to hen's egg allergy
| Project/Area Number |
19591268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fujita Health University |
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Principal Investigator |
URISU Atsuo Fujita Health University, 医学部, 教授 (20193972)
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| Co-Investigator(Kenkyū-buntansha) |
柘植 郁哉 藤田保健衛生大学, 医学部, 准教授 (00231431)
近藤 康人 藤田保健衛生大学, 医学部, 准教授 (30301641)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 小児免疫 / アレルギー / 膠原病学 / 鶏卵アレルギー / 免疫療法 / オボムコイド減量加熱全卵 / TGF-βmRNA / IFN-γ / IP-10mRNA / IL-4も、mRNA / Th1 / Th2 / IL-4 / IL-13 / Eotaxin / SOCS-3 / 経口免疫寛容 / CISH |
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| Research Abstract |
The efficiency of oral immunotherapy for food allergy has been already approved in many articles. The IT is associated in varying degrees with side effects such as urticaria, abdominal pain and anaphylaxis. We have made heated and ovomucoid-reduced whole egg, upgraded hypoallergenic food antigens for IT. The IT using this egg antigen has been proved the safety and efficiency in this study. The response of Th2 cytokine (IL4) as well as Th1 cytokine (IFN-gamma) in peripheral mononuclear cells was decreased after the stimulation by egg white antigen in vitro.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Interlaboratory evaluation of two enzyme-linked immunesorbent assay kits for the determination of crustacean protein in processed foods2008
Author(s)
Sakai S, Matsuda, R, Adachi R, Akiyama H, Maitani T, Ohno, Y., Oka, M., Abe, A., Seiki, K., Oda, H., Shiomi, K., Urisu, A.
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Journal Title
J AOAC Int 91
Pages: 123-129
Related Report
Peer Reviewed
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[Presentation] Long-term oral immunotherapy by hypoallergenic heated and ovomucoid-reduced egg white in subjects with hen's egg allergy.2009
Author(s)
Urisu A, Naruse N, Ahn J, Komatsubara R, Hirata N, Yukawa M, Suzuki S, Ando H, Kondo Y, Tsuge I, Yamada K, Kobayashi S, Kimura
Organizer
European Academy of Allergy and Clinical Immunology Pediatric Allergy & Asthma Meeting
Place of Presentation
Venice Italy
Related Report
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[Presentation] Oral immunotherapy by heated and ovomucoid-reduced egg white to children with hen's egg hypersensitivity.2008
Author(s)
Urisu A, Komatsubara R, Hirata N, Kakami M, Kawada Yasusuke, Nakajima Y, Yukawa M, Kondo Y, Tsuge I, Tokuda R, Yamada K, Kimura M
Organizer
Congress of European Academy of Allergology and Clinical Immunology (EAACI)
Related Report
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[Presentation] Food Labeling and the Epidemiology of Food Allergy, Food Labeling in Japan and Food Allergen Purification2008
Author(s)
Urisu A, Nakajima Y, Komatsubara R, Hirata N, Yukawa M, Kakami M, Kondo Y, Tsuge I
Organizer
Pediatric Academic Societies and Asian Society for Peditric Reaseach 2008 Joint Meeting
Place of Presentation
Honolulu, Hwaii, USA
Related Report
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