Developmental changes in cerebral oxygen metabolism during neonatal period

• Project/Area Number: 19591281
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kagawa University
• Principal Investigator: KUSAKA Takashi Kagawa University, 医学部附属病院, 講師 (50274288)
• Co-Investigator(Kenkyū-buntansha): UENO Masaki 香川大学, 医学部, 准教授 (30322267) ; MIKI Takanori 香川大学, 医学部, 准教授 (30274294) ; NAMBA Masanori 香川大学, 医学部, 助教 (90237636) ; NISHIDA Tomoko 香川大学, 医学部・附属病院, 助教 (00243759) ; IWASE Takashi 香川大学, 医学部・附属病院, 助教 (30284368) ; OKUBO Kensuke 香川大学, 医学部, 助教 (80335851) ; KUBOI Toru 香川大学, 医学部・附属病院, 病院助教 (00437683)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: Near-infrared spectroscopy / Time-resolved spectroscopy / 脳血液量 / 脳組織Hb酸素飽和度 / 低酸素性虚血性脳症 / 遅発性脳エネルギー代謝不全 / 脳酸素代謝量 / 早産児 / 新生児貧血 / 新生児

Research Abstract

新生児期の脳酸素代謝の特徴は、早産児は正期産児と比較し脳血液量、酸素代謝量が低く、在胎週数と共に増加する。しかし低酸素虚血性脳症や脳室内出血を来たす病態では、出後早期には脳の循環自動調節能が破綻し、脳血液量が増加し、酸素消費量も低下する事が示唆された。特に低酸素虚血性脳症のエネルギー代謝障害時には、軽症例では酸素消費量が減少するが、重症例では脳血流上昇後に脳浮腫が進行し虚血が進行すると考えられた。

Research Products

• [Journal Article] Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum (2010)
  • Author(s): Wang ZY, Miki T, Lee KY, Yokoyama T, Kusaka T, Sumitani K, Warita K, Matsumoto Y, Yakura T, Hosomi N, Ameno K, Bedi KS, Takeuchi Y.
  • Journal Title: Neuroscience 20 ; 165 (2) Pages: 485-9
  • Peer Reviewed
• [Journal Article] Two families with compound heterozygosity for adenine phosphoribosyltransferase deficiency (2010)
  • Author(s): Iwaki T, Kusaka T, Ohashi I, Nishida T, Imai T, Itoh S.
  • Journal Title: Pediatr Nephrol. 26
  • Peer Reviewed
• [Journal Article] (EZ)-Cyclobilirubin formation from bilirubin in complex with serum albumin derived from various species (2010)
  • Author(s): Iwase T, Kusaka T, Itoh S.
  • Journal Title: J Photochem Photobiol B. 12 ; 98 (2) Pages: 138-143
  • Peer Reviewed
• [Journal Article] Relationship between cerebral oxygenation and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets (2009)
  • Author(s): Kusaka T, Ueno M, Miki T, Kuboi T, Nakamura S, Koyano K, Ijichi S, Yasuda S, Okubo K, Kawada K, Namba M, Nishida T, Imai T, Isobe K, Itoh S.
  • Journal Title: Pediatr Res. 65 (3) Pages: 317-22
  • Peer Reviewed
• [Journal Article] Age-related changes in P-glycoprotein expression in senescence-accelerated mouse (2009)
  • Author(s): Wu B, Ueno M, Onodera M, Kusaka T, Huang CL, Hosomi N, Kanenishi K, Sakamoto H.
  • Journal Title: Curr Aging Sci. 2 (3) Pages: 187-92
  • Peer Reviewed
• [Journal Article] Functional optical hemodynamic imaging of the olfactory cortex in normosmia subjects and dysosmia subjects (2009)
  • Author(s): Kobayashi E, Karaki M, Kusaka T, Kobayashi R, Itoh S, Mori N.
  • Journal Title: Acta Otolaryngol Suppl. 562 Pages: 79-84
  • Peer Reviewed
• [Journal Article] RAGE, LDL receptor, and LRP1 expression in the brains of SAMP8 (2009)
  • Author(s): Wu B, Ueno M, Onodera M, Kusaka T, Huang CL, Hosomi N, Kanenishi K, Sakamoto H.
  • Journal Title: Neurosci Lett 18 ; 461 (2) Pages: 100-5
  • Peer Reviewed
• [Journal Article] Pharmacokinetics of prophylactic micafungin in very-low-birth-weight infants (2009)
  • Author(s): Kawada M, Fukuoka N, Kondo M, Okazaki K, Kusaka T, Kawada K, Itoh S.
  • Journal Title: Pediatr Infect Dis J. 28 (9) Pages: 840-2
  • Peer Reviewed
• [Journal Article] Abcb1a and Abcb1b expression in senescence-accelerated mouse (SAM) (2009)
  • Author(s): Wu B, Ueno M, Kusaka T, Onodera M, Huang CL, Hosomi N, Kanenishi K, Sakamoto H.
  • Journal Title: Neurosci Lett 29 ; 456 (1) Pages: 34-8
  • Peer Reviewed
• [Journal Article] The expression of matrix metalloproteinase-13 is increased in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model (2009)
  • Author(s): Ueno M, Wu B, Nishiyama A, Huang CL, Hosomi N, Kusaka T, Nakagawa T, Onodera M, Kido M, Sakamoto H.
  • Journal Title: Hypertens Res. 20
  • NAID: 10026122370
  • Peer Reviewed
• [Journal Article] The expression of P-glycoprotein is increased in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model (2009)
  • Author(s): Ueno M, Nakagawa T, Huang CL, Ueki M, Kusaka T, Hosomi N, Kanenishi K, Onodera M, Wu B, Sakamoto H.
  • Journal Title: Neuropathol Appl Neurobiol. 35 (2) Pages: 147-55
  • Peer Reviewed
• [Journal Article] The expression of P-glycoprotein is increased in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model (2009)
  • Author(s): Ueno M, Nakagawa T, Huang C, Ueki M, Kusaka T, Hosomi N, Kanenishi K, Onodera M, Wu B, Sakamoto H.
  • Journal Title: Neuropathol Appl Neurobiol. 35 (2) Pages: 147-55
  • Peer Reviewed
• [Journal Article] 新生児の脳循環代謝評価における近赤外光の応用 (2009)
  • Author(s): 日下隆
  • Journal Title: 脈管学 (0387-1126)49巻2号 Pages: 163-168
  • NAID: 10025219934
• [Journal Article] Relationship between cerebral oxygenation and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets. (2009)
  • Author(s): Kusaka T, Ueno M, Miki T, Kuboi T, Nakamura S, Koyano K, Ijichi S, Yasuda S, Okubo K, Kawada K, Namba M, Nishida T, Imai T, Isobe K, Itoh S.
  • Journal Title: Pediatr Res. 65 Pages: 317-322
  • Peer Reviewed
• [Journal Article] The expression of P-glycoprotein is increased in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model. (2009)
  • Author(s): Ueno M, Nakagawa T, Huang CL, Ueki M, Kusaka T, Hosomi N, Kanenishi K, Onodera M, Wu B, Sakamoto H.
  • Journal Title: Neuropathol Appl Neurobiol. 35 Pages: 147-155
  • Peer Reviewed
• [Journal Article] The expression of matrix metalloproteinase-13 is increased in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model. 2009 Mar 20. (2009)
  • Author(s): Ueno M, Wu B, Nishiyama A, Huang CL, Hosomi N, Kusaka T, Nakagawa T, Onodera M, Kido M, Sakamoto H.
  • Journal Title: Hypertens Res. (未定)(In press)
  • Peer Reviewed
• [Journal Article] Abcbla and Abcblb expression in senescence-accelerated mouse (SAM) (2009)
  • Author(s): Wu B, Ueno M, Kusaka T, Onodera M, Huang CL, Hosomi N, Kanenishi K, Sakamoto H.
  • Journal Title: Neurosci Lett. 2009 (未定)(In press)
  • Peer Reviewed
• [Journal Article] The pharmacokinetics and safety of prophylactic micafungin in very lowbirth weight infants (2009)
  • Author(s): Kawada M, Fukuoka N, Kondo M, Okazaki K, Kusaka T, Kawada K, Itoh S.
  • Journal Title: Pediatric Infectious Disease Journal. (未定)(In press)
  • Peer Reviewed
• [Journal Article] 遅発性脳障害のtherapeutic window (2009)
  • Author(s): 日下 隆
  • Journal Title: 日本周産期・新生児医学会雑誌、 44 Pages: 869-871
  • NAID: 10025166530
• [Journal Article] 近赤外光分析 (2009)
  • Author(s): 日下 隆
  • Journal Title: 周産期医学 38 Pages: 479-483
• [Journal Article] Changes in breast hemodynamics in breastfeeding mothers (2008)
  • Author(s): Ogawa K, Kusaka T, Tanimoto K, Nishida T, Isobe K, Itoh S.
  • Journal Title: J Hum Lact 24 (4) Pages: 415-21
  • Peer Reviewed
• [Journal Article] Extrauterine environment affects the cortical responses to verbal stimulation in preterm infants (2008)
  • Author(s): Nishida T, Kusaka T, Isobe K, Ijichi S, Okubo K, Iwase T, Kawada K, Namba M, Imai T, Itoh S.
  • Journal Title: Neurosci Lett 26 ; 443 (1) Pages: 23-6
  • Peer Reviewed
• [Journal Article] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus (2008)
  • Author(s): Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, S Bedi K, Itoh S, Nakamura Y, Takeuchi Y.
  • Journal Title: Acta Neurobiol Exp (Wars) 68 (4) Pages: 484-93
  • Peer Reviewed
• [Journal Article] Relationship between muscle oxygenation and electromyography activity during sustained isometric contraction (2008)
  • Author(s): Yamada E, Kusaka T, Arima N, Isobe K, Yamamoto T, Itoh S.
  • Journal Title: Clin Physiol Funct Imaging 28 (4) Pages: 216-21
  • Peer Reviewed
• [Journal Article] 脳性麻痺は防止できるか? 遅発性脳障害の therapeutic window (2008)
  • Author(s): 日下隆
  • Journal Title: 日本周産期・新生児医学会雑誌 (1348-964X)44巻4号 Pages: 869-871
• [Journal Article] 周産期臨床検査のポイント (2008)
  • Author(s): 日下隆
  • Journal Title: 基本的な検査 近赤外光分析、周産期医学 (0386-9881)38巻増刊 Pages: 479-483
• [Journal Article] 未熟児・新生児の脳循環代謝 (2008)
  • Author(s): 日下隆
  • Journal Title: 日本未熟児新生児学会雑誌 (1347-8540)20巻1号 Pages: 41-45
  • NAID: 10022598504
• [Journal Article] changes in breast hemodynamics in breastfeeding mothers. (2008)
  • Author(s): Ogawa K, Kusaka T, Tanimoto K, Nishida T, Isobe K, Itoh S.
  • Journal Title: J Hum Lact. 24 Pages: 415-421
  • Peer Reviewed
• [Journal Article] Ethanol neurotoxicity and dentate gyrus development. (2008)
  • Author(s): Miki T, Yokoyama T, Sumitani K, Kusaka T, Warita K, Matsumoto Y, Wang ZY, Wilce PA, Bedi KS, ItohS, Takeuchi Y.
  • Journal Title: Congenit Anom(Kyoto). 48 Pages: 110-117
  • NAID: 10027387376
  • Peer Reviewed
• [Journal Article] Extrauterine environment affects the cortical responses to verbal stimulation in preterm infants. (2008)
  • Author(s): Nishida T, Kusaka T, Isobe K, Ijichi S, Okubo K, Twase T, Kawada K, Namba M, Imai T, Itoh S.
  • Journal Title: Neurosci Lett. 26 Pages: 23-26
  • Peer Reviewed
• [Journal Article] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus. (2008)
  • Author(s): Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, S Bedi K, Itoh S, Nakamura Y, Takeuchi Y.
  • Journal Title: Acta Neurobiol Exp (Wars). 68 Pages: 484-493
  • Peer Reviewed
• [Journal Article] Extrauterine environment affects the cortical responses to verbal stimulation in preterm infants (2008)
  • Author(s): Nishida T, Kusaka T, Isobe K, Ijichi S, et al.
  • Journal Title: Neurosci Lett (掲載確定)
  • Peer Reviewed
• [Journal Article] Changes in breast hemodynamics in breastfeeding mothers (2008)
  • Author(s): Ogawa K, Kusaka T, Tanimoto K, et al. .
  • Journal Title: J Human Lactation (掲載確定)
  • Peer Reviewed
• [Journal Article] Relationship between muscle oxygenation and electromyography activity during sustained isometric contraction (2008)
  • Author(s): Yamada E, Kusaka T, Arima N, Isobe K, Yamamoto T, Itoh S.
  • Journal Title: Clin Physiol Funct Imaging 28(4) Pages: 216-221
  • Peer Reviewed
• [Journal Article] 未熟児・新生児の脳循環代謝 (2008)
  • Author(s): 日下隆
  • Journal Title: 日本未熟児新生児学会雑誌 20-1 Pages: 41-45
  • NAID: 10022598504
• [Journal Article] Accumulation of triosephosphate isomerase, with sequence homology to amyloid peptides, in vessel walls of the newborn piglet hippocampus (2007)
  • Author(s): Kusaka T, Ueno M, Miki T, et al.
  • Journal Title: Microscopy Research and Technique 70 (7) Pages: 648-55
  • Peer Reviewed
• [Journal Article] Functional optical hemodynamic imaging of the olfactory cortex (2007)
  • Author(s): Kobayashi E, Kusaka T, Karaki M, et al.
  • Journal Title: Laryngoscope 117 (3) Pages: 541-6
  • Peer Reviewed
• [Journal Article] The effect of prenatal X-irradiation on the developing cerebral cortex of rats. II : A quantitative assessment of glial cells in the somatosensory cortex (2007)
  • Author(s): Miki T, Yokoyama T, Sumitani K, Wang ZY, Yang W, Kusaka T, Matsumoto Y, Warita K, Lee NS, Fukui Y, Takeuchi Y.
  • Journal Title: International Journal of Developmental Neuroscience 25 (5) Pages: 293-7
  • Peer Reviewed
• [Journal Article] Accumulation of triosephosphate isomerase, with sequence homology to beta amyloid peptides, in vessel walls of the newborn piglet hippocampus (2007)
  • Author(s): Kusaka T, Ueno M, Miki T, et al.
  • Journal Title: Microsc Res Tech 70(7) Pages: 648-55
  • Peer Reviewed
• [Journal Article] The effect of prenatal X-irradiation on the developing cerebral cortex of rats. II: A quantitative assessment of glial cells in the somatosensory cortex (2007)
  • Author(s): Miki T, Yokoyama T, Sumitani K, et al.
  • Journal Title: Int J Dev Neurosci 25(5) Pages: 293-7
  • Peer Reviewed
• [Journal Article] Functional optical hemodynamic imaging of the olfactory cortex (2007)
  • Author(s): Kobayashi E, Kusaka T, Karaki M, et al.
  • Journal Title: Laryngoscope 117(3) Pages: 541-6
  • Peer Reviewed
• [Journal Article] 拡散光トモグラフィ装置を用いた未熟児頭部のin vivo測定 (2007)
  • Author(s): 上野雅範, 福沢遼, 大川晋平, 日下隆
  • Journal Title: 第19回バイオエンジニアリング講演会講演論文集 06-05 Pages: 338-9
• [Presentation] ブルネイ国と日本における生後72時間以内の経皮ビリルビン値の比較～人種と栄養法の違い～ (2009)
  • Author(s): 久保井徹, 大橋育子, 小谷野耕佑, 大久保賢介, 河田興, 日下隆, 磯部健一, 伊藤進
  • Organizer: 第53回日本未熟児新生児学会
  • Place of Presentation: 札幌コンベンションセンター, 北海道
  • Year and Date: 2009-10-31
• [Presentation] In vitro でのグリーンLEDを用いたビリルビン光異性体の推移の検討 第3報 臨床応用に向けて、他のベッド型光療法器との比較 (2009)
  • Author(s): 岩瀬孝志, 久保井徹, 河田興, 日下隆, 西田智子, 今井正, 磯部健一, 伊藤進
  • Organizer: 第53回日本未熟児新生児学
  • Place of Presentation: 札幌コンベンションセンター, 北海道
  • Year and Date: 2009-10-31
• [Presentation] 近赤外光時間分解測定法をもちいた生体計測-特に新生児医療における応用 (2009)
  • Author(s): 日下隆
  • Organizer: 第11回日本光脳機能イメージング研究会
  • Place of Presentation: 財団法人星陵会 星陵会館、東京都
  • Year and Date: 2009-07-18
• [Presentation] 新生仔豚を用いた新しい長期予後の検討可能な新生児仮死モデルの作成 (2009)
  • Author(s): 安田真之, 高橋昌志, 中村信嗣, 小谷野耕佑, 小谷野薫, 久保井徹, 大久保賢介, 日下隆, 磯部健一, 伊藤進
  • Organizer: 第45回日本周産期・新生児医学会
  • Place of Presentation: 名古屋国際会議場、愛知県
  • Year and Date: 2009-07-14
• [Presentation] 新生児高ビリルビン血症に対するグリーンLEDの開発 (2009)
  • Author(s): 岩瀬孝志, 久保井徹, 安田真之, 日下隆, 磯部健一, 伊藤進
  • Organizer: 第45回日本周産期・新生児医学会
  • Place of Presentation: 名古屋国際会議場、愛知県
  • Year and Date: 2009-07-13
• [Presentation] neo BLUE cozy を用いた光療法におけるビリルビン光異性体の検討 (2009)
  • Author(s): 久保井徹, 高橋昌志, 安田真之, 大久保賢介, 日下隆, 磯部健一, 伊藤進
  • Organizer: 第45回日本周産期・新生児医学会
  • Place of Presentation: 名古屋国際会議場、愛知県
  • Year and Date: 2009-07-13
• [Presentation] グリーンLEDを用いたビリルビン光異性体の動態 (2009)
  • Author(s): 岩瀬孝志, 久保井徹, 安田真之, 日下隆, 磯部健一, 伊藤進
  • Organizer: 第8回UB研究会
  • Place of Presentation: 高松市, サンポートホール高松、香川県
  • Year and Date: 2009-06-27
• [Presentation] 経皮ビリルビン上昇速度による早発黄疸の生後早期スクリーニングに関する検討 (2009)
  • Author(s): 中村信嗣, 山本真由美, 日下隆, 安田真之, 久保井徹, 大久保賢介, 磯部健一, 伊藤進
  • Organizer: 第8回UB研究会
  • Place of Presentation: サンポートホール高松、香川県
  • Year and Date: 2009-06-27
• [Presentation] 早発黄疸の早期発見のためのPCソフトの開発 (2009)
  • Author(s): 久保井徹, 高橋昌志, 大久保賢介, 安田真之, 日下隆, 磯部健一, 伊藤進
  • Organizer: 第8回UB研究会
  • Place of Presentation: サンポロートホール高松、香川県
  • Year and Date: 2009-06-27
• [Presentation] 多チャンネルNIRSを用いた言語刺激と音楽刺激に対する反応の発達的変化について (2009)
  • Author(s): 西田智子, 伊地知園子, 小西行彦, 河田真由美, 大久保賢介, 難波正則, 日下隆, 今井正, 磯部健一, 伊藤進
  • Organizer: 第51回日本小児神経学会
  • Place of Presentation: 米子コンベンションセンター、鳥取県
  • Year and Date: 2009-05-29
• [Presentation] 低酸素虚血性脳症の遅発性エネルギー代謝障害での脳内エネルギーと酸素代謝の関係 (2009)
  • Author(s): 日下隆, 久保井徹, 安田真之, 難波正則, 大久保賢介, 西田智子, 磯部健一, 伊藤進, 中村信嗣, 小谷野耕佑
  • Organizer: 第112回日本小児科学会
  • Place of Presentation: 奈良県文化会館、奈良県
  • Year and Date: 2009-04-19
• [Presentation] 新生児仮死モデルを用いたアポトーシスタンパク質のチロシンリン酸化の検討 (2009)
  • Author(s): 安田真之, 久保井徹, 大久保賢介, 日下隆, 今井正, 磯部健一, 伊藤進
  • Organizer: 第112回日本小児科学
  • Place of Presentation: 奈良県文化会館、奈良県
  • Year and Date: 2009-04-19
• [Presentation] 低酸素虚血性脳症の遅発性エネルギー代謝障害での脳内エネルギーと酸素代謝の関係 (2009)
  • Author(s): 日下隆, 久保井徹, 安田真之, 難波正則, 大久保賢介, 西田智子, 磯部健一, 伊藤進, 中村信嗣, 小谷野耕佑.
  • Organizer: 第112回日本小児科学会学術集会
  • Place of Presentation: 奈良市
  • Year and Date: 2009-04-19
• [Presentation] えっ! 光でわかる脳の代謝 (2009)
  • Author(s): 日下隆
  • Organizer: 第11回新生児呼吸療法モニタリングフォーラム
  • Place of Presentation: 長野県
  • Year and Date: 2009-02-20
• [Presentation] え! 光でわかるの頭の代謝 (2009)
  • Author(s): 日下隆
  • Organizer: 第11回新生児呼吸療法モニタリングフォーラム
  • Place of Presentation: 長野県、大町市
• [Presentation] 教育講演「新生児期に必要な検査とその意義-ビリルビンと酸素- (2008)
  • Author(s): 日下隆
  • Organizer: 平成20年度香川県総合周産期母子医療研修会
  • Place of Presentation: 香川大学医学部、香川県
  • Year and Date: 2008-11-15
• [Presentation] 近赤外光を利用した新生児の脳循環・代謝評価 (2008)
  • Author(s): 日下隆
  • Organizer: 第38回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸国際会議場、兵庫県
  • Year and Date: 2008-11-14
• [Presentation] Optical brain imaging in infants by use of near-infrared diffuse optical tomography (2008)
  • Author(s): Takashi Kusaka, Shinpei Okawa, Masanori Ueno, Ryo Fukuzawa, Tomoko Nishida, Kenichi Isobe, Yukari Tanikawa, Feng Gao, Chie Sato, Yoko Hoshi, Yukio Yamada
  • Organizer: The 36th Annual Conference of International Society on Oxygen Transport to Tissue (ISOTT 2008)
  • Place of Presentation: 札幌
  • Year and Date: 2008-08-04
• [Presentation] ブルネイ国と日本における生後72時間以内の新生児の経皮ビリルビン値の比較 (2008)
  • Author(s): 久保井徹, 小谷野耕佑, 中村信嗣, 大久保賢介, 河田興, 日下隆, 磯部健一, 伊藤進
  • Organizer: 第44回日本周産期・新生児医学会
  • Place of Presentation: 横浜市, パシフィコ横浜、神奈川県
  • Year and Date: 2008-07-15
• [Presentation] シンポジウム3「脳性麻痺は防止できるか?」遅発性脳障害の therapeutic window (2008)
  • Author(s): 日下隆
  • Organizer: 第44回日本周産期・新生児医学会
  • Place of Presentation: 横浜市, パシフィコ横浜、神奈川県
  • Year and Date: 2008-07-13
• [Presentation] 遅発性脳障害のtherapeutic window (2008)
  • Author(s): 日下隆
  • Organizer: 第44回日本周産期・新生児医学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-07-13
• [Presentation] New Optical Cerebral Imaging in Infants by using Near-infrared Diffuse Optical Tomography (2008)
  • Author(s): Kusaka T, Ueno M, Fukuzawa R, Okawa S, Yamada Y, Nishida T, Tanikawa Y, Gao F, Sato C, Hoshi Y.
  • Organizer: The Second International Symposium on Complex Medical Engineering 2008
  • Place of Presentation: Kagawa International Conference Hall, Takamatsu, Kagawa, Japan
  • Year and Date: 2008-05-30
• [Presentation] The Cortical Responses to Verbal Stimulation in Preterm Infants (2008)
  • Author(s): Nishida T, Kusaka T, Isobe K, Ijichi S, Kuromi T, Okubo K, Iwase T, Kawada K, Namba M, Imai T, Itoh S.
  • Organizer: The Second International Symposium on Complex Medical Engineering 2008
  • Place of Presentation: Kagawa International Conference Hall, Takamatsu, Kagawa, Japan
  • Year and Date: 2008-05-30
• [Presentation] An in Vitro Study for Clinical Application of Near-infrared Time-resolved Spectroscopy to Infant Brain (2008)
  • Author(s): Isobe K, Okubo K, Kawada K, Nishida T, Kusaka T, Itoh S.
  • Organizer: The Second International Symposium on Complex Medical Engineering 2008
  • Place of Presentation: Kagawa International Conference Hall, Takamatsu, Kagawa, Japan
  • Year and Date: 2008-05-30
• [Presentation] 早産児における脳内酸素化状態の発達的変化について (2008)
  • Author(s): 伊地知園子, 西田智子, 難波正則, 河田真由美, 小西行彦, 大久保賢介, 日下隆, 今井正, 磯部健一, 伊藤進
  • Organizer: 第50回日本小児神経学会
  • Place of Presentation: ホテル日航東京、東京都
  • Year and Date: 2008-05-30
• [Presentation] The Cortical Responses to Verbal Stimulation in Preterm Infants (2008)
  • Author(s): Nshida T, Kusaka T, Isobe K, Ijichi S, Okubo K, Iwase T, Kawada K, Namba M, Imai T, Itoh S.
  • Organizer: 15th Congress of the FAOPS 2008
  • Place of Presentation: Nagoya Congress Center, Nagoya, Japan
  • Year and Date: 2008-05-22
• [Presentation] Transcutaneous bilirubin (TcB) levels during the first 72 hours in 2421 newborn infants of Brunei Darussalam (2008)
  • Author(s): Hjh Emilia binte Hj Kassim, Kusaka T, Maskaton Samsuddin, Elizabeth Chong, Mas Rina Wati Haji Abdul Hamid, Kuboi T, Konishi Y, Itoh S.
  • Organizer: 15^<th> Congress of the FAOPS 2008
  • Place of Presentation: Nagoya Congress Center, Nagoya, Japan
  • Year and Date: 2008-05-22
• [Presentation] New cerebral optical imaging in infants by using near-infrared diffuse optical tomography (2008)
  • Author(s): Kusaka T, Ueno M, Fukuzawa R, Okawa S, Yamada Y, Nishida T, Isobe K, Tanikawa Y, Gao F, Sato C, Hoshi Y.
  • Organizer: 15^<th> Congress of the FAOPS 2008
  • Place of Presentation: Nagoya Congress Center, Nagoya, Japan
  • Year and Date: 2008-05-22
• [Presentation] 新生仔豚脳でのβ-アミロイド様蛋白はtriosephosphate isomeraseであった (2008)
  • Author(s): 日下隆, 伊藤進, 上野正樹.
  • Organizer: 第111回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-27
• [Presentation] 近赤外光断層イメージングを用いた早産児の脳循環・代謝の検討 (第4報) (2008)
  • Author(s): 日下隆, 西田智子, 磯部健一, 伊藤進
  • Organizer: 第111回日本小児科学会学術集会
  • Place of Presentation: 東京国際フォーラム、東京都
  • Year and Date: 2008-04-25
• [Presentation] 未熟児貧血における輸血療法時の脳血液量の検討 (第2報) (2008)
  • Author(s): 小谷野耕佑, 中村信嗣, 小谷野薫, 久保井徹, 大久保賢介, 西田智子, 磯部健一, 伊藤進, 河田興, 日下隆
  • Organizer: 第111回日本小児科学会学術集会
  • Place of Presentation: 東京国際フォーラム、東京都
  • Year and Date: 2008-04-25
• [Presentation] 新生仔豚脳でのβ-アミロイド様蛋白は triosephos-phate isomerase であった (2008)
  • Author(s): 日下隆, 伊藤進, 上野正樹
  • Organizer: 第111回日本小児科学会学術集会
  • Place of Presentation: 東京国際フォーラム、東京都
  • Year and Date: 2008-04-25
• [Presentation] 近赤外光断層イメージングを用いた早産児の脳循環・代謝の検討(第4報)、 (2008)
  • Author(s): 日下隆, 西田智子, 磯部健一, 伊藤進.
  • Organizer: 第111回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-25
• [Presentation] Optical brain imaging in infants by use of near-infrared diffuse optical tomography (2008)
  • Author(s): Kusaka T, Okawa S, Ueno M, Fukuzawa R, Nishida T, Isobe K, Tanikawa Y, Gao F, Sato C, Hoshi Y, Yamada Y.
  • Organizer: International Society on Oxygen Transport to Tissue 2008 2008 (ISOTT2008)
  • Place of Presentation: Sapporo, Japan
• [Presentation] Effect of knee arthroplasty on changes in cerebral blood flow during isometric knee extension (2008)
  • Author(s): Morita S, Kusaka T, Yamada E.
  • Organizer: International Society on Oxygen Transport to Tissue 2008 (ISOTT2008)
  • Place of Presentation: Sapporo, Japan
• [Presentation] Transcutaneous bilirubin (TcB) levels during the first 72 hours in 2421 newborn infants of Brunei Darussalam (2008)
  • Author(s): Takashi Kusaka, Hjh Emilia binte Hj Kassim, Maskaton Samsuddin, Elizabeth Chong, Mas Rina Wati Haji Abdul Hamid, Toru Kuboi, Yukihiko Konishi, Susumu Itoh
  • Organizer: 15th congress of the federation of Asia and Oceania Perinatal Societies
  • Place of Presentation: 名古屋
• [Presentation] New cerebral optical imaging in infants by using near-infrared diffuse optical tomography (2008)
  • Author(s): Takashi Kusaka, Masanori Ueno, Ryo Fukuzawa, Shinpei Okawa, Yukio Yamada, Tomoko Nishida, Kenichi Isobe, Yukari Tanikawa, Feng Gao, Chie Sato, Yoko Hoshi
  • Organizer: 15th congress of the federation of Asia and Oceania Perinatal Societies
  • Place of Presentation: 名古屋
• [Presentation] New optical brain imaging in infants by using near-infrared diffuse optical tomography (2008)
  • Author(s): Takashi Kusaka, Shinpei Okawa, Masanori Ueno, Ryo Fukuzawa, Tomoko Nishida, Kenichi Isobe, Yukari Tanikawa, Feng Gao, Chie Sato, Yoko Hoshi, Yukio Yamada
  • Organizer: The 12th Conference of Peace through Mind / Brain Science
  • Place of Presentation: 浜松市
• [Presentation] 未熟児貧血における輸血療法時の脳血液量の検討(第2報) (2008)
  • Author(s): 小谷野耕佑、中村信嗣、小谷野薫、久保井徹、大久保賢介、西田智子、磯部健一、伊藤進、河田興、日下隆
  • Organizer: 第111回日本小児科学会
  • Place of Presentation: 東京都
• [Presentation] New cerebral optical imaging in infants by using near-infrared diffuse optical tomography (2008)
  • Author(s): Kusaka T, et al.
  • Organizer: 15th congress of the federation of Asia and Oceania Perinatal Societies
  • Place of Presentation: 名古屋市
• [Presentation] Optical brain imaging in infants by use of near-infrared diffuse optical tomography (2008)
  • Author(s): Kusaka T, et al.
  • Organizer: The 36th Annual Conference of International Society on Oxygen Transport to Tissue
  • Place of Presentation: 札幌市
• [Presentation] Effect of knee arthroplasty on changes in cerebral blood flow durine isometric knee extension (2008)
  • Author(s): Morita S, Kusaka T, et al.
  • Organizer: The 36th Annual Conference of International Society on Oxygen Transport to Tissue
  • Place of Presentation: 札幌市
• [Presentation] 新生仔豚脳でのβ-アミロイド様蛋白はtoiosephosphate isomeraseであった (2008)
  • Author(s): 日下隆、伊藤進、上野正樹
  • Organizer: 第111回日本小児科学会
  • Place of Presentation: 東京都
• [Presentation] 近赤外光断層イメージングを用いた早産児の脳循環・代謝の検討(第4報) (2008)
  • Author(s): 日下隆、西田智子、磯部健一、伊藤進
  • Organizer: 第111回日本小児科学会
  • Place of Presentation: 東京都
• [Presentation] 授乳中の母親の乳房血液の変化 (2007)
  • Author(s): 小川佳代, 谷本公恵, 伊地知園子, 西里智子, 日下隆, 大久保賢介, 磯部健一, 伊藤進
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: サンポート高松、香川県
  • Year and Date: 2007-11-26
• [Presentation] 教育講演4 未熟児・新生児の脳代謝循環 (2007)
  • Author(s): 日下隆
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: サンポート高松、香川県
  • Year and Date: 2007-11-25
• [Presentation] 新生児貧血に対する輸血療法時の脳血液量の変化 (2007)
  • Author(s): 小谷野耕佑, 中村信嗣, 小谷野薫, 久保井徹, 大久保賢介, 河田興, 日下隆, 西田智子, 磯部健一, 伊藤進
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: サンポート高松、香川県
  • Year and Date: 2007-11-24
• [Presentation] 低酸素性虚血性脳症における脳循環・代謝状態の経時的変動 (第3報) (2007)
  • Author(s): 中村信嗣, 小谷野耕佑, 大橋育子, 伊地知園子, 久保井徹, 大久保賢介, 西田智子, 河田興, 日下隆, 磯部健一, 伊藤進
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: サンポート高松、香川県
  • Year and Date: 2007-11-24
• [Presentation] 近赤外光断層イメージングを用いた早産児頭部測定に関する基礎的研究 (第3報) (2007)
  • Author(s): 日下隆, 西田智子, 磯部健一, 伊藤進
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: サンポート高松、香川県
  • Year and Date: 2007-11-24
• [Presentation] コニカミノルタ黄疸計JM-103による新生児黄疸の管理 (コンピューターソフト) (2007)
  • Author(s): 久保井徹, 小谷野耕佑, 中村信嗣, 小西行彦, 大久保賢介, 河田興, 日下隆, 今井正, 磯部健一, 伊藤進
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: サンポート高松、香川県
  • Year and Date: 2007-11-24
• [Presentation] ワークショップ2「未熟児新生児の黄疸管理」コニカミノルタ黄疸計JM-103による新生児黄疸の管理 (ノモグラム)-溶血性黄疸例で経皮ビリルビン値は高値である- (2007)
  • Author(s): 久保井徹, 河田興, 河田真由美, 大久保賢介, 日下隆, 今井正, 磯部健一, 伊藤進
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: サンポート高松、香川県
  • Year and Date: 2007-11-24
• [Presentation] ブルネイ国における生後72時間以内の新生児の経皮黄疸計基準値の検討 (2007)
  • Author(s): 日下隆, 久保井徹, 伊藤進
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: サンポート高松、香川県
  • Year and Date: 2007-11-24
• [Presentation] LEDライトを用いた光療法後の血清総ビリルビン値のリバウンドについて (2007)
  • Author(s): 久保井徹, 岩城拓磨, 加藤育子, 大久保賢介, 河田興, 日下隆, 今井正, 磯部健一, 伊藤進
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: サンポート高松、香川県
  • Year and Date: 2007-11-24
• [Presentation] 新生児貧血に対する輸血療法時の脳血液量の変化 (2007)
  • Author(s): 小谷野耕佑、中村信嗣、小谷野薫、久保井徹、大久保賢介、河田興、日下隆、西田智子、磯部健一、伊藤進
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: 香川県
  • Year and Date: 2007-11-24
• [Presentation] 低酸素性虚血性脳症における脳循環・代謝状態の経時的変動(第3報) (2007)
  • Author(s): 中村信嗣、小谷野耕佑、大橋育子、伊地知園子、久保井徹、大久保賢介、西田智子、河田興、日下隆、磯部健一、伊藤進
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: 香川県
  • Year and Date: 2007-11-24
• [Presentation] 近赤外光断層イメージングを用いた早産児頭部測定に関する基礎的研究(第2報) (2007)
  • Author(s): 日下隆、西田智子、磯部健一、伊藤進
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: 香川県
  • Year and Date: 2007-11-24
• [Presentation] 授乳中の母親の乳房血液の変化 (2007)
  • Author(s): 小川佳代、谷本公恵、伊地知園子、西田智子、日下隆、大久保賢介、磯部健一、伊藤進
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: 香川県
  • Year and Date: 2007-11-24
• [Presentation] シンポジウムII「NIRSの臨床・研究への応用-光でみる生体機能」新生児の脳循環代謝評価における近赤外光の応用 (2007)
  • Author(s): 日下隆
  • Organizer: 第14回医用近赤外線分光法研究会
  • Place of Presentation: まつもと市民芸術館、長野県
  • Year and Date: 2007-10-27
• [Presentation] Transcutaneous bilirubin (TcB) levels in the first 72 hours in newborn inafants of Brunei Darussalam (2007)
  • Author(s): Kusaka T, Maskaton Samsuddin, Hjh Emilia binte Hj Kassim, Elizabeth Chong, Mas Rina Wati Haji Abdul Hamid, Kuboi T, Konishi Y, Itoh S.
  • Organizer: The 3rd Congress of Asian Society for Pediatric Research
  • Place of Presentation: National Center of Sciences, Tokyo, Japan
  • Year and Date: 2007-10-08
• [Presentation] New optidal brain imaging in infants by using near-infrareddiffuse optical tomography (2007)
  • Author(s): Kusaka T, Ueno M, Fukuzawa R, Okawa S, Yamada Y, Okubo K, Isobe K, Tanikawa Y, Gao F, Sato C, Hoshi Y.
  • Organizer: The 3rd Congress of Asian Society for Pediatric Research
  • Place of Presentation: National Center of Sciences, Tokyo, Japan
  • Year and Date: 2007-10-07
• [Presentation] Cerebral hemodynamics in asphyxiated infants measured by using near-infrared time-resolved spectroscopy (2007)
  • Author(s): Nishida T, Koyano K, Nakamura S, Kuboi T. Ijichi S, Kuromi T, Okubo K, Kusaka T, Imai T, Isobe K,Itoh S.
  • Organizer: The 3rd Congress of Asian Society for Pediatric Research
  • Place of Presentation: National Center of Sciences, Tokyo, Japan
  • Year and Date: 2007-10-07
• [Presentation] New optical brain imaging in infants by using near-infrareddiffuse optical tomography (2007)
  • Author(s): Takashi Kusaka, Masanori Ueno, Ryo Fukuzawa, Shinpei Okawa, Yukio Yamada, Kensuke Okubo, Kenichi Isobe, Yukari Tanikawa, Fens Gao, Chie Sato, Yoko Hoshi.
  • Organizer: The 3rd Congress of Asian Society for Pediatric Research
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2007-10-07
• [Presentation] Cerebral hemodynamics in asphyxiated infants measured by using near-infrared time-resolved spectroscopy (2007)
  • Author(s): Tomoko Nishida, Kousuke Koyano, Sinji Nakamura, Toru Kuboi, Sonoko Ijichi, Tetsuo Kuromi, Kensuke Okubo, Takashi Kusaka, Tadashi Imai, Kenichi Isobe, Susumu Itoh.
  • Organizer: The 3rd Congress of Asian Society for Pediatric Research
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2007-10-07
• [Presentation] In vivo measurement of premature neonate head using diffuse optical tomography (2007)
  • Author(s): Ueno M, Fukuzawa R, Okawa S, Yamada Y, Kusaka T, Nishida T, Isobe K, Tanikawa Y, Gao F, Sato C, Hoshi Y.
  • Organizer: APBP 2007 3rd Asian and Pacific Rim Symposium on Biophotonics & Biophotonics Downunder II
  • Place of Presentation: Shangri-La Hotel, Cairns, Australia
  • Year and Date: 2007-07-10
• [Presentation] 新生児黄疸の管理法-第2報- (2007)
  • Author(s): 久保井徹, 小谷野耕佑, 中村信嗣, 岩城拓磨, 大久保賢介, 河田興, 日下隆, 今井正, 磯部健一, 伊藤進
  • Organizer: 第43回日本周産期・新生児医学会学術集会
  • Place of Presentation: グランドプリンスホテル赤坂、東京都
  • Year and Date: 2007-07-10
• [Presentation] In vivo measurement of premature neonate head using diffuse optical tomography (2007)
  • Author(s): Masanori Ueno, Ryo Fukuzawa, Shinpei Okawa, Yukio Yamada, Takashi Kusaka, Tomoko Nishida, Kenichi Isobe, Yukari Tanikawa, Feng Gao, Chie Sato, Yoko Hoshi.
  • Organizer: APBP2007 3rd Asian and Pacific Rim Symposium on Biophotonics & Biophotonics Downunder II
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2007-07-10
• [Presentation] 低酸素性虚血性脳症 (HIE) における生後の脳内酸素化状態の変化について (2007)
  • Author(s): 西田智子, 難波正則, 河田真由美, 小西行彦, 大久保賢介, 日下隆, 今井正, 磯部健一, 伊藤進
  • Organizer: 第49回日本小児神経学会
  • Place of Presentation: 大阪国際会議場、大阪府
  • Year and Date: 2007-07-05
• [Presentation] 低酸素性虚血性脳症(HIE)における生後の脳内酸素化状態の変化について (2007)
  • Author(s): 西田智子、難波正則、河田真由美、小西行彦、大久保賢介、日下隆、今井正、磯部健一、伊藤進
  • Organizer: 第49回日本小児神経学会
  • Place of Presentation: 大阪府
  • Year and Date: 2007-07-05
• [Presentation] New Optical Cerebral Imaging in Infants (2007)
  • Author(s): Kusaka T.
  • Organizer: The 14^<th> Annual Spring Meeting of the KSN
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-05-25
• [Presentation] New Optical Cerebral Imaging in Infants (2007)
  • Author(s): Takashi Kusaka.
  • Organizer: The 14thannual spring meeting of the Korean Society of Neonatology
  • Place of Presentation: Korea, Seoul
  • Year and Date: 2007-05-25
• [Presentation] 新生児仮死蘇生後の脳内酸素化状態と予後との関係 (2007)
  • Author(s): 西田智子, 阿部多恵, 伊地知園子, 難波正則, 日下隆, 今井正, 磯部健一, 伊藤進
  • Organizer: 第110回日本小児科学会
  • Place of Presentation: 国立京都国際会館、京都府
  • Year and Date: 2007-04-21
• [Presentation] 新生児仮死蘇生後の脳内酸素化状態と予後との関係 (2007)
  • Author(s): 西田智子、阿部多恵、伊地知園子、難波正則、日下隆、今井正、磯部健一、伊藤進
  • Organizer: 第110回日本小児科学会
  • Place of Presentation: 京都府
  • Year and Date: 2007-04-21
• [Book] からだと酸素の辞典酸素ダイナミクス研究会編集 (2009)
  • Author(s): 日下隆
  • Publisher: 朝倉書店