Epigenetic mechanism underlying olfactory learning in young animal
| Project/Area Number |
19591282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
OKUTANI Fumino Kochi University, 教育研究部医療学系, 准教授 (10194490)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 新生児医学 / 記憶・学習 / 幼若ラット / 嗅覚 / ヒストン / 脱アセチル化 |
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| Research Abstract |
Preweanling young rats prior to eye opening depend on somatosensory and olfactory function for survival, as they can learn their dam's odor and approach her without visual information. In order to establish olfactory learning, the pairing of odor and somatosensory stimulation is crucial. We have previously shown that synaptic plasticity in the OB underlies aversive olfactory learning. Particularly as cellular mechanisms, chromatin structure is remodeled by modification of histone acetylation during the early stages of long-term memory formation. Behavioral pharmacology shows that HDAC inhibition consolidates aversive olfactory learning in young rats.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Effects of olfactory stimulation with isovaleric acid on brain activation in informed and naive conditions: A functional MRT study.2007
Author(s)
Murata, Y. Okutani, F. Nakahira, M. Ushida, T. Ikemoto, T. Yokoe, I. Takeda, T. Kaba, H. Tani, T., Ogawa, Y.
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Journal Title
Auri s Nasus Larynx 34
Pages: 465-469
Related Report
Peer Reviewed
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[Presentation] 嫌いなにおいの情報処理過程2007
Author(s)
奥谷文乃, 川久保真衣, 村田和子, 中平光彦, 牛田享宏, 椛秀人
Organizer
日本味と匂学会第41回大会
Place of Presentation
東京都タワーホール船堀
Year and Date
2007-07-28
Related Report
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