| Project/Area Number |
19591290
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
NAKANISHI Keiko Institute for Developmental Research, Aichi Human Service Center, 周生期学部, 主任研究員 (50280813)
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| Research Collaborator |
大平 敦彦 愛知医科大学, 先端医学医療研究拠点, 客員教授
佐藤 義朗 名古屋大学, 周産母子センター, 病院助教
山田 恭聖 愛知県心身障害者コロニー中央病院, 新生児科, 医長
伊藤 美春 愛知県心身障害者コロニー中央病院, 新生児科, 医師
青野 幸子 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員
時田 義人 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員
松井 ふみ子 愛知県心身障害者コロニー発達障害研究所, 研究員
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 新生児低酸素性虚血性脳症 / 神経幹細胞 / oxygen-glucose depletion / Oxygen glucose depletion / ニューロングリア共培養系 / oxygen glucose depletion / ニューロン・グリア共培養 / コンドロイチナーゼ |
|---|
| Research Abstract |
Administration of neural stem/progenitor cells (NSPCs) with chondroitinase (CHase) reduced brain injury in a neonatal hypoxic-ischemic rat model. To investigate its mechanism, we established in vitro hypoxic-ischemic model. GFP-transgenic rat neurons were cultured and exposed to oxygen-glucose depletion (OGD). Treatment with NSPCs combined with CHase was tended to reduce OGD-induced neuronal cell death. We are currently trying to find the factors regulating neuroprotection using this model.
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