Investigation of the role of novel angiogenic factor-ANGPT16-in pathogenesis of psoriasis

• Project/Area Number: 19591312
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Ehime University
• Principal Investigator: HANAKAWA Yasushi Ehime University, 大学院・医学系研究科, 講師 (90284398)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 皮膚病理学 / 乾癬 / モデルマウス / AGF / 血管新生 / K14プロモーター

Research Abstract

表皮特異的にangiopoietin-related factor (AGF)をケラチン14 プロモーター下流に発現するトランスジェニックマウスを用いて慢性の皮膚の炎症性疾患である乾癬の病態形成へのAGF の関与について研究を行った。AGF は表皮細胞の過増殖を引き起こすことおよび真皮上層の毛細血管の増生をもらすことなどより乾癬の病態形成への関与が示唆された。

Research Products

• [Journal Article] Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of Stat3 function (2008)
  • Author(s): Zhu P, Hata R, Cao F, Gu F, Hanakawa Y, Hashimoto K, Sakanaka M.
  • Journal Title: FASEB J. 22(11) Pages: 3866-77
  • Peer Reviewed
• [Journal Article] PPAR gamma is an important transcription factor in 1 alpha, 25-dihydroxyvitamin D3-induced involucrin expression (2008)
  • Author(s): Dai X, Sayama K, Shirakata Y, Tokumaru S, Yang L, Tohyama M, Hirakawa S, Hanakawa Y, Hashimoto K
  • Journal Title: J Dermatol Sci. 50(1) Pages: 53-60
  • Peer Reviewed
• [Journal Article] Ramified microglial cells promote astrogliogenesis and maintenance of neuralstem cells through activation of Stat3 function (2008)
  • Author(s): Zhu P, et al.
  • Journal Title: FASEB J. 22 Pages: 3866-77
  • Peer Reviewed
• [Journal Article] PPAR gamma is an inportant transcription factcr in alpha, 25-dihydroxyvitamin D3-induced involucrin expression. (2008)
  • Author(s): Dai X, et. al.
  • Journal Title: J Dermatol Sci. 50 Pages: 53-60
  • Peer Reviewed
• [Journal Article] CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes (2007)
  • Author(s): Tohyama M, Sayama K, Komatsuzawa H, Hanakawa Y, Shirakata Y, Dai X, Yang L, Tokumaru S, Nagai H, Hirakawa S, Sugai M, Hashimoto K
  • Journal Title: Int Immunol. 19(9) Pages: 1095-102
  • NAID: 10020108093
  • Peer Reviewed
• [Journal Article] Suppressor of cytokine signaling 3 negative regulation of signal transducer and activator of transcription 3 in platelet-derived growth factor-induced fibroblast migration (2007)
  • Author(s): Nagai H, Tokumaru S, Sayama K, Shirakata Y, Hanakawa Y, Hirakawa S, Dai X, Tohyama M, Yang L, Hashimoto K
  • Journal Title: J Dermatol. 34(8) Pages: 523-30
  • NAID: 10021306180
  • Peer Reviewed
• [Journal Article] STAT5a/PPARgamma pathway regulates involucrin expression in keratinocyte differentiation (2007)
  • Author(s): Dai X, Sayama K, Shirakata Y, Hanakawa Y, Yamasaki K, Tokumaru S, Yang L, Wang X, Hirakawa S, Tohyama M, Yamauchi T, Takashi K, Kagechika H, Hashimoto K.
  • Journal Title: J Invest Dermatol. 127(7) Pages: 1728-35
  • Peer Reviewed
• [Journal Article] Epiregulin, a member of the EGF family, is over-expressed in psoriatic epidermis (2007)
  • Author(s): Shirakata Y, Kishimoto J, Tokumaru S, Yamasaki K, Hanakawa Y, Tohyama M, Sayama K, Hashimoto K
  • Journal Title: J Dermatol Sci. 45(1) Pages: 69-72
  • NAID: 10019994988
  • Peer Reviewed
• [Journal Article] Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression (2007)
  • Author(s): Shiraishi K, Yamasaki K, Nanba D, Inoue H, Hanakawa Y, Shirakata Y, Hashimoto K, Higashiyama S
  • Journal Title: Oncogene. 26(3) Pages: 339-48
  • Peer Reviewed
• [Journal Article] CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes (2007)
  • Author(s): Tohyama M, et. al.
  • Journal Title: Int Immunol 19(9) Pages: 1095-102
  • Peer Reviewed
• [Journal Article] Suppressor of cytokine signaling 3 negative regulation of signal transducer and activator of transcription 3 in platelet-derived growth factor-induced fibroblast migration (2007)
  • Author(s): Nagai H, et. al.
  • Journal Title: J Dermatol 34(8) Pages: 523-30
  • Peer Reviewed
• [Journal Article] STAT5a/PPAR gamma pathway regulates involucrin expression in keratinocyte differentiation (2007)
  • Author(s): Dai X, et. al.
  • Journal Title: J Invest Dermatol 127(7) Pages: 1728-35
  • Peer Reviewed
• [Presentation] Keratinocyte-specific SOCS3 knockout mice show clinical phenotype of human psoriasis (2008)
  • Author(s): 裕司、花川靖、徳丸晶、平川聡史、藤山幹子、佐山浩二、橋本公二
  • Organizer: 第22回表皮細胞研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-03
• [Presentation] 乾癬の表皮角化細胞におけるIL22Rの発現増強とIL-20Subfamilyの産生について (2008)
  • Author(s): 藤山幹子、花川靖、白方裕司、平川聡史、佐山浩二、橋本公二
  • Organizer: 第15回分子皮膚科学フォーラム
  • Place of Presentation: 京都
  • Year and Date: 2008-11-05
• [Presentation] Nuclear translocation of phosphorylated STAT3 is essential for lymphatic endothelial cell migration induced by VEGF-A International Investigative Dermatology (2008)
  • Author(s): 徳丸晶、白方裕司、花川靖、平川聡史、藤山幹子、佐山浩二、橋本公二
  • Place of Presentation: Kyoto
  • Year and Date: 2008-05-18
• [Presentation] Conditional ablation of Ubc 13, a mediator of innate immunity, in keratinocytes induces abnormal differentiation, decreased proliferation, and apoptosis (2008)
  • Author(s): 佐山浩二、花川靖、白方裕司、橋本公二.
  • Organizer: International Investigative Dermatology
  • Place of Presentation: Kyoto
  • Year and Date: 2008-05-17
• [Presentation] Angiopoietin-related growth factor : 新規血管増殖因子の多面的生物活性 (2007)
  • Author(s): 聡史、佐山浩二、白方裕司、藤山幹子、花川靖、橋本公二
  • Organizer: 第14回分子皮膚科フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2007-09-30
• [Presentation] Keratinocyte specific ablation of TAK1 in mouse induces abnormal hair development (2007)
  • Author(s): 佐山浩二、白方裕司、花川靖、平川聡史、橋本公二
  • Organizer: 第32回日本研究皮膚科学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-04-20
• [Presentation] Involvement of STAT3/SOCS signaling pathway in PDGF-induced fibroblast migration (2007)
  • Author(s): 徳丸晶、佐山浩二、白方裕司、花川靖、平川聡史、藤山幹子、橋本公二
  • Organizer: 第32回日本研究皮膚科学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-04-19