Regulation of chemokine production in human epidermal keratinocyte by IL-17 stimulation

• Project/Area Number: 19591313
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Ehime University
• Principal Investigator: TOYAMA Mikiko Ehime University, 医学部・附属病院, 助教 (60263935)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 皮膚生理学 / サイトカイン / 表皮角化細胞 / ケモカイン / IL-17 / CTACK / IRF1 / MIP-1beta

Research Abstract

皮膚の慢性炎症性疾患として、アトピー性皮膚炎、乾癬がよく知られており、どちらの疾患の病変部位にもIL-17 を産生するリンパ球が存在している。炎症の誘導には、表皮角化細胞より産生されるケモカインが重要な役割を果たしているが、疾患によりその発現パターンは異なっている。ケモカインの産生は炎症性サイトカインで誘導されるが、IL-17 の存在が、その産生を制御していることを明らかにした。

Research Products

• [Journal Article] A marked increase in serum soluble Fas ligand in drug-induced hypersensitivity syndrome (2008)
  • Author(s): Tohyama M, et.al.
  • Journal Title: Br J Dermatol 159 Pages: 981-984
  • Peer Reviewed
• [Journal Article] CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes (2008)
  • Author(s): Tohyama M, et.al.
  • Journal Title: Int Immunol 19 Pages: 1095-1102
  • Peer Reviewed
• [Journal Article] A marked increase in serum soluble Fas ligand in drug-induced hypersensitivity syndrome. (2008)
  • Author(s): Tohyama M, et al.
  • Journal Title: Br J Dermatol 159 Pages: 981-4
  • Peer Reviewed
• [Journal Article] Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome (2007)
  • Author(s): Tohyama M, et.al.
  • Journal Title: Br J Dermatol 157 Pages: 934-940
  • Peer Reviewed
• [Journal Article] CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes (2007)
  • Author(s): Tohyama M, et. al.
  • Journal Title: Int Immunol 19 Pages: 1095-1102
  • Peer Reviewed
• [Journal Article] Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome (2007)
  • Author(s): Tohyama M, et. al.
  • Journal Title: Br J Dermatol 157 Pages: 934-940
  • Peer Reviewed
• [Presentation] Augmentation of IL-22 receptor expression and IL-20 subfamily production plays a critical role in psoriasis (2008)
  • Author(s): Tohyama M.
  • Organizer: a International Investigative Dermatology 2008
  • Place of Presentation: 京都
  • Year and Date: 2008-05-17
• [Presentation] Augmentation of IL-22 receptor expression and IL-20 subfamily production plays a critical role in psoriasis (2008)
  • Author(s): Tohyama M, et al.
  • Organizer: International Investigative Dermatology 2008
  • Place of Presentation: 京都
  • Year and Date: 2008-05-17
• [Presentation] Novel mechanism of Stevens-Johnson syndrome and TEN : involvement of fractalkine and CD16+ mononuclear cells. (2007)
  • Author(s): Tohyama M.
  • Organizer: 第32回研究皮膚科学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-04-20
• [Presentation] Nover mechanism of Stevens-Hohnson syndrom and TEN:involvement of fractalkine and CD16+mononuclear cells (2007)
  • Author(s): Tohyama M, et. al.
  • Organizer: 第32回日本研究皮膚科学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-04-20