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A study on the effectiveness of statins for diabetic wounds

Research Project

Project/Area Number 19591321
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

TAKENAKA Hideya  Kyoto Prefectural University of Medicine, 大学院・医学研究科, 講師 (80254358)

Co-Investigator(Kenkyū-buntansha) ASAI Jun  京都府立医科大学, 医学研究科, 助教 (50438222)
II Masaaki  独立行政法人理化学研究所, 幹細胞医療応用研究チーム, 研究員 (10442922)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords皮膚病理学 / 創傷治癒 / 糖尿病 / 血管新生 / リンパ管 / 細胞・組織 / 再生医学
Research Abstract

スタチンは、高コレステロール血症治療薬であるが、血管新生促進作用があることが知られてきた。そこで、スタチンによる糖尿病性潰瘍などの難治性潰瘍に対する新規治療法の開発に向けて実験を行った。糖尿病マウスの皮膚潰瘍に対し、スタチンの全身投与および外用投与を行った。スタチンを投与した群の方が、創傷治癒が促進し、創部により多くの血管およびリンパ管が新生した。スタチンの外用剤が、糖尿病性潰瘍の治療薬になる可能性が示された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (5 results)

All 2009 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Infantile myofibromatosis of the scrotum.2007

    • Author(s)
      Ichihashi K, Takenaka H, Asai J, et. al.
    • Journal Title

      European Journal of Dermatology 18(1)

      Pages: 82-83

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Platelets in Leukocyte Recruitment in Chronic Contact Hypersensitivity Induced by Repeated Elicitation.2007

    • Author(s)
      Tamagawa R, Katoh N, UedaE, Takenaka H, et. al.
    • Journal Title

      The American Journal of Pathology 170(6)

      Pages: 2019-2029

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atypical form of necrobiosis lipoidica associated with lymphoedema.2007

    • Author(s)
      Morihara K, Takenaka H, Morihara T, Kishimoto S.
    • Journal Title

      Journal of the European Academy of Dermatology and Venereology 21

      Pages: 831-833

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis2009

    • Author(s)
      Asai J, Takenaka H, et al.
    • Organizer
      69^<th> Annual Meeting of the Society for Investigative Dermatology
    • Place of Presentation
      Montreal, Canada.
    • Related Report
      2008 Final Research Report
  • [Presentation] 創傷治癒過程におけるAMD3100,CXCR4拮抗剤の役割2007

    • Author(s)
      西村幸秀、竹中秀也、浅井 純、他
    • Organizer
      第58回日本皮膚科学会中部支部学術大会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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