CSF Histamine levels in patients with hypersomnia, and hypothalamic peptides in recurrent hypersomnia

• Project/Area Number: 19591337
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Akita University
• Principal Investigator: SHIMIZU Tetsuo Akita University, 医学部, 教授 (90170977)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 過眠症 / オレキシン / ヒスタミン / Kleine-Levin syndrome / 反復性過眠症 / αMSH / AGRP / Klein-Levin syndrome

Research Abstract

髄液ヒスタミン値が過眠症状に依存性に低値であることが明らかになった。コントロ-ルに比べて、HLA-DR2陽性で脱力発作のあるオレキシンが低値のナルコレプシ-だけではなく、オレキシン値は正常である特発性過眠症、DR2 陰性や脱力発作のないナルコレプシ-でもヒスタミン値は有意に低値であった。しかしながら、リタリン等の中枢神経刺激薬を内服している症例では、対照群との有意差は認められなかった。ナルコレプシ-ではリタリンの内服の有無にて、オレキシン値に変化はないが、ヒスタミン値に関しては、高値になる傾向がみられた。ヒスタミン値は、睡眠時無呼吸症では対照群と同等な値であった。

Research Products

• [Journal Article] CSF histamine contents in narcolepsy, idiopathic hypersomnia and obstructive sleep apnea syndrome (2009)
  • Author(s): Kanbayashi T, Kodama T, Kondo H, Satoh S, Inoue Y, Chiba S, Shimizu T, Nishino S.
  • Journal Title: Sleep 32(2) Pages: 181-7
  • Peer Reviewed
• [Journal Article] Symptomatic Narcolepsy in Neuromyelitis Optica and Multiple Sclerosis Patients ; New Neurochemical and Immunological Implications (2009)
  • Author(s): Kanbayashi T, Shimohata T, Nakashima I, Shimizu T, Nishino S.
  • Journal Title: Arch Neurol. 66(in press)
  • Peer Reviewed
• [Journal Article] Cerebrospinal fluid-orexin levels and sleep attacks in four patients with Parkinson's disease (2009)
  • Author(s): Asai H, Hirano M, Furiya Y, Udaka F, Kanbayashi T, Shimizu T, Ueno S.
  • Journal Title: Clin Neurol Neurosurg 111(4) Pages: 341-4
  • Peer Reviewed
• [Journal Article] Narcolepsy as an initial manifestation of neuromyelitis optica with anti-aquaporin-4 antibody (2009)
  • Author(s): Baba T, Nakashima I, Kanbayashi T, Konno M, Takahashi T, Fujihara K, Misu T, Takeda A, Shiga Y, Ogawa H, Itoyama Y.
  • Journal Title: J Neurol. 256(2) Pages: 287-8
  • Peer Reviewed
• [Journal Article] Symptomatic Narcolepsy in Neuromyelitis Optica and Multiple Sclerosis Patients; New Neurochemical and Immunological Implications (2009)
  • Author(s): Kanbayashi T, Shimohata T, Nakashima I, Shimizu T, Nishino S.
  • Journal Title: Arch Neurol 66(in press)
  • Peer Reviewed
• [Journal Article] 視床下部病変によりオレキシン神経障害を来して生じた2次性の過眠症 (2008)
  • Author(s): 神林崇、清水徹男, 等
  • Journal Title: 睡眠医療 2 Pages: 157-164
• [Journal Article] CSF histamine levels in narcolepsy, idiopathic hypersomnia and obstructive sleep apnea syndrome (2008)
  • Author(s): T.Kanbayashi, T. Shimizu, et. al.
  • Journal Title: SLEEP 31(In press)
  • Peer Reviewed
• [Journal Article] 視床下部病変によりオレキシン神経障害を来して生じた2次性の過眠症 (2008)
  • Author(s): 神林崇、清水徹男等
  • Journal Title: 睡眠医療 2 Pages: 157-164
• [Presentation] CSF HYPOCRETIN-1 (OREXIN-A) MEASUREMENT IN PEDIATRIC AND TEENAGE PATIENTS WITH SLEEP DISORDERS (2009)
  • Author(s): Arii J, Kanbayashi T, Shimizu T
  • Organizer: 22nd Annual Meeting of the Associated Professional Sleep Societies
  • Place of Presentation: Baltimore, Maryland, USA
  • Year and Date: 2009-06-10
• [Presentation] CSF HYPOCRETIN-1 (OREXIN-A) MEASUREMENT IN PEDIATRIC AND TEENAGE PATIENTS WITH SLEEP DISORDERS (2008)
  • Author(s): Arii J, Kanbayashi T, Shimizu T.
  • Organizer: 22nd Annual Meeting of the Associated Professional Sleep Societies
  • Place of Presentation: Baltimore, Maryland, USA
  • Year and Date: 2008-06-10
• [Presentation] AVERAGE HYPOCRETIN AND ELEVATED AGRP IN THE CSF OF PATIENTS WITH ANOREXIA NERVOSA SLEEP (2008)
  • Author(s): Maruyama F, Kanbayashi T, Satoh S, Okuda M, Aizawa R, Ogawa-Hayashi Y, Ishikawa H, Takemura F, Sagawa Y, Shimizu T.
  • Organizer: Volume 31, Abstract Supplement
  • Place of Presentation: (A215-16)
• [Book] NARCOLEPSY(in press) (2009)
  • Author(s): Kanbayashi T, Shimizu T
  • Publisher: Nishino Humana/Springer
• [Book] NARCOLEPSY (2009)
  • Author(s): Kanbayashi T, Shimizu T, Nishino S.
  • Publisher: Humana/Springer(in press)