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Genome-wide association study of panic disorder

Research Project

Project/Area Number 19591340
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionThe University of Tokyo

Principal Investigator

UMEKAGE Tadashi (2008)  The University of Tokyo, 環境安全本部, 准教授 (20323587)

梅景 正 (2007)  The University of Tokyo, 保健センター, 講師 (19591340)

Co-Investigator(Kenkyū-buntansha) SASAKI Tsukasa  東京大学, 学生支援ネットワーク本部, 教授 (50235256)
Co-Investigator(Renkei-kenkyūsha) SASAKI Tsukasa  東京大学, 学生支援ネットワーク本部, 教授 (50235256)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsパニック障害 / 遺伝子 / ゲノムワイド関連研究 / 遺伝子解析 / NIRS
Research Abstract

本研究は、パニック障害患者を対象にゲノムワイド関連解析(Genome-wide associationstudy)を行なうものである。東京大学精神神経科を中心とする当グループは、すでに日本人患者のサンプルを1100例(世界最大規模)収集した。その中の患者200例(と健康対照者200例)について、Affymetric社の500K SNPチップを使用し全ゲノム解析を行った結果、アリル頻度の患者-対照比較で有意差(P<0.0001)を示す50個のSNPsが見出された。現在さらに800例について全ゲノム解析を進めている.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (27 results)

All 2009 2008 2007 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (8 results) Book (9 results)

  • [Journal Article] Noassociation between the brain-derivedneurotrophic factor (BDNF) gene and panicdisorder in Japanese population2009

    • Author(s)
      Otowa T, Shimada T, Kawamura Y, Liu X,Inoue K, Sugaya N, Minato T, Nakagami R, Tochigi M, Umekage T, Kasai K, Kato N, Tanii H, Okazaki Y, Kaiya H, Sasaki T.
    • Journal Title

      J Hum Genet (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Okazaki YGenome-wide association study of panic disorder in theJapanese population2009

    • Author(s)
      Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K, Tochigi M, UmekageT, Miyagawa T, Nishida N, Tokunaga K, TaniiH, Sasaki T, Kaiya H.
    • Journal Title

      J Hum Genet 54(2)

      Pages: 122-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of panic disorder in the Japanese population2009

    • Author(s)
      T Otowa
    • Journal Title

      J Hum Genet 54(2)

      Pages: 122-6

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Appropriate data cleaning methods forgenome-wide association study2008

    • Author(s)
      Miyagawa T, Nishida N, Ohashi J, Kimura R, Fujimoto A, Kawashima M, Koike A, SasakiT, Tanii H, Otowa T, Momose Y, Nakahara Y, Gotoh J, Okazaki Y, Tsuji S, Tokunaga K.
    • Journal Title

      J Hum Genet 53(10)

      Pages: 886-93

    • NAID

      10022602964

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Birth months and vulnerability to juveniledelinquency2008

    • Author(s)
      Ohtani T, Sasaki T, Kadomoto I, Kato N, Yoshinaga C.
    • Journal Title

      Prog Neuropsycopharmacol Biol Psychiatry 32

      Pages: 49-53

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Appropriate data cleaning methods for genome-wide association study2008

    • Author(s)
      T Miyagawa
    • Journal Title

      J Hum Genet 53(10)

      Pages: 886-93

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Birth months and vulnerability to juvenile dolinqucncy2008

    • Author(s)
      Ohtuni T, Sasaki T, Kadomoto I, Kato N, Yoshinuga C.
    • Journal Title

      Prog Neuropsycopharmacol Biol Psychiatry 32

      Pages: 49-53

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study of monoamine oxidase and catechol-O-methyltransferase genes withsmoking behavior2007

    • Author(s)
      Tochigi M, Suzuki K, Kato C, Otowa T, Hibino H, Umekage T, Kato N, Sasaki T.
    • Journal Title

      Pharmacogenet Genomics 17(10)

      Pages: 867-72

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association study of monoamine oxidase and catechol-O-methyltransferase genes with smoking behavior.2007

    • Author(s)
      Tochigi M. Suzuki K. Kato C. Otowa T. Hibino H. Umokago T. Kato N. Sasuki
    • Journal Title

      Pharmacogenet Genomics 17(10)

      Pages: 867-72

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No association between the brain-derived neurotrophic factor (BDNF) gene and panic disorder in Japanese population

    • Author(s)
      T Otowa
    • Journal Title

      J Hum Genet in press

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] The Relationship between Cognitive Factors and Agoraphobia in PanicDisorder Patients with Irritable Bowel Syndrome2009

    • Author(s)
      N Sugaya, E Yoshida, S Yasuda, A109MTochigi, K Takei, T Otani, T Otowa, TMinato, T Umekage, Y Sakano, J Chen, SNomura, H Shimada, H Tanii, T Sasaki, YOkazaki, H Kaiya
    • Organizer
      20th World Congress on PSYCHOSOMATIC MEDICINE
    • Place of Presentation
      Torino Italy
    • Year and Date
      2009-09-24
    • Related Report
      2008 Final Research Report
  • [Presentation] Changes in Changes of cerebral blood volumeduring a verbal fluency task in patientswith social anxiety disorder : Amulti-channel near-infrared spectroscopystudy2009

    • Author(s)
      C Yokoyama, H Kaiyal, Y Nishimura, H Tanii, M Kinou1, T Otowa, T Umekage, S Yasuda, KTakei, Y Kaneko, S Suzuki, T Sasaki, Yokazaki
    • Organizer
      第1回日本不安障害学会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 不安障害の生物学-遺伝的研究の立場から2009

    • Author(s)
      音羽健司, 佐々木司
    • Organizer
      第1回日本不安障害学会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 不安障害の生物学-遺伝的研究の端から-2009

    • Author(s)
      音羽健司
    • Organizer
      第1回日本不安障害学会
    • Place of Presentation
      早稲田大学国際会議場
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Relationship between Cognitive Factors and Agoraphobia in Panic Disorder Patients with Irritable Bowel Syndrome2009

    • Author(s)
      N Sugaya
    • Organizer
      20th World Congress on PSYCHOSOMATIC MEDICINE
    • Place of Presentation
      Torino, Italy
    • Related Report
      2008 Annual Research Report
  • [Presentation] クモ恐怖症に対するエクスポージャー法のNIRS による効果検証2007

    • Author(s)
      長谷川誠、福井 至、Douglas Eames、久保田俊一郎、梅景 正、宇佐美英里、吉田栄治、貝谷久宣
    • Organizer
      第33回日本行動療法学会
    • Place of Presentation
      神戸
    • Year and Date
      2007-11-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Phsophodiesterase 4B (PDE4B) is potentialrisk locus of panic disorder : evidencefrom genome-wide association study2007

    • Author(s)
      T Otowa, M Tochigi, T Umekage, N Sugaya, KInoue, E Yoshida, H Tanii, Y Okazaki, HKaiya, K Tokunaga, T Sasaki
    • Organizer
      World Congress on Psychiatric Genetics XV
    • Place of Presentation
      New York
    • Year and Date
      2007-10-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Phsophodiesterase 4B(PDE4B)is potential risk locus of panic disorder:evidence from genome-wide association study2007

    • Author(s)
      Takoshi Ota〓 Mamoru Tochigi Tadashi Umokago, Nagi〓n Sagaya, Ken lnoue 〓Yoshida, 〓isashi Tunii, Yuji Okazuki, 〓an〓bu Kalya, Katsushi Tokunaga, Tsukasa Snsnld
    • Organizer
      World Congress on Psychiatric Genetics XV
    • Place of Presentation
      New York
    • Related Report
      2007 Annual Research Report
  • [Book] パニック障害の全ゲノム関連研究2009

    • Author(s)
      音羽健司, 佐々木司
    • Publisher
      医歯薬出版
    • Related Report
      2008 Final Research Report
  • [Book] 入院の診立て・判断-パニック障害の場合2009

    • Author(s)
      貝谷久宣、吉田栄治、土田英人、梅景 正
    • Publisher
      星和書店
    • Related Report
      2008 Final Research Report
  • [Book] パニック障害の全ゲノム関連研究2009

    • Author(s)
      音羽健司
    • Total Pages
      4
    • Publisher
      医歯薬出版
    • Related Report
      2008 Annual Research Report
  • [Book] 入院の診立て・判断-パニック障害の場合2009

    • Author(s)
      貝谷久宣
    • Total Pages
      6
    • Publisher
      星和書店
    • Related Report
      2008 Annual Research Report
  • [Book] 疲労とパニック障害2008

    • Author(s)
      貝谷久宣、岩佐玲子、梅景 正、栃木 衛、山中 学、土田英人
    • Publisher
      医学書院
    • Related Report
      2008 Final Research Report
  • [Book] パニック障害の遺伝子心療内科2008

    • Author(s)
      音羽健司、佐々木司
    • Publisher
      科学評論社
    • Related Report
      2008 Final Research Report
  • [Book] 疲労とパニック障害2008

    • Author(s)
      貝谷久宣
    • Total Pages
      7
    • Publisher
      医学書院
    • Related Report
      2008 Annual Research Report
  • [Book] パニック障害2007

    • Author(s)
      貝谷久宣、井上 顕、横山知加、土田英人、山中 学、梅景 正、栃木 衛
    • Publisher
      Journal of Otolaryngology, Head and Surgery
    • Related Report
      2008 Final Research Report
  • [Book] Journal of Otolaryngology, Head and Surgery 23(3)541-544 パニック障害2007

    • Author(s)
      貝谷久宣、井上 顕、横山知加、土田英人、山中 学、梅景 正、栃木 衛
    • Total Pages
      4
    • Publisher
      東京医学社
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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