The effect of newel antipsychotic drugs on the Incidente of metabolic syndrome

• Project/Area Number: 19591344
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Niigata University
• Principal Investigator: SOMEYA Toshiyuki Niigata University, 医歯学系, 教授 (50187902)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Yutaro 新潟大学, 医歯学総合病院, 講師 (60377158) ; SAWAMURA Kazushi 新潟大学, 医歯学総合病院, 助教 (60444155)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: メタボリックシンドローム / 新規抗精神病薬 / 統合失調症 / 75gOGTT / 薬力学 / 薬物動態学 / オランザピン / メタボリックシンドローム(MS) / 生物学的マーカー

Research Abstract

本研究によって、抗精神病薬服用中の統合失調症患者では空腹時血糖値が正常範囲にあるにもかかわらず、すでに糖代謝異常をきたしている症例が多い可能性が示唆され、統合失調症患者の糖代謝異常モニタリングはより注意深く行なう必要性があると考えられた。また新規抗精神病薬オランザピンによって惹起される持続性の体重増加予測因子としてアディポネクチン遺伝子45T/G多型が有用である可能性が示唆された. 今後は同一個体で他の新規抗精神病薬についても同様の検討する必要がある。

Research Products

• [Journal Article] Hypoglycemia induced by second generation antipsychotic agents in non-diabetic schizophrenic patients. (2009)
  • Author(s): Suzuki Y Watanabe J Fukui N, Ozdemir V, Someya T
  • Journal Title: BMJ (印刷中)
  • Peer Reviewed
• [Journal Article] Concentration-response relationship for fluvoxamine using remission as an endpoint : A receiver operating characteristics curve analysis in major depression (2008)
  • Author(s): Suzuki Y, Fukui N, Sawamura K, Sugai T,Watanabe J, Ono S, Inoue Y, Ozdemir V, Someya T
  • Journal Title: J Clin Psychopharmacol 28(3) Pages: 325-328
  • Peer Reviewed
• [Journal Article] Large-scale case-control study of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia (letter) (2008)
  • Author(s): Nunokawa A, Watanabe Y, Kitamura H, Kaneko N, Arinami T, Ujike H, Inada T, wata N, Kunugi H, Itokawa M, Ozaki N, Someya T
  • Journal Title: Psychiatry Clin Neurosci 62(2) Pages: 239-240
  • Peer Reviewed
• [Journal Article] Association study of interleukin-2 (IL2) and 1L4 with schizophrenia in a Japanese population (2008)
  • Author(s): Watanabe Y, Nunokawa A, Shibuya M, Kaneko N, Nawa H, Someya T
  • Journal Title: Eur Arch Psychiatry CI in Neurosci 258(7) Pages: 422-427
  • Peer Reviewed
• [Journal Article] Concentration-response relationship for fluvoxamine using remission as an endpoint: A receiver operating characteristics curve analysis in major depression. (2008)
  • Author(s): Suzuki Y, Fukui N, Sawamura K, Sugai T, Watanabe J, Ono S, Inoue Y, Ozdemir V, Someya T
  • Journal Title: J Clin Psychopharmacol 28(3) Pages: 325-328
  • Peer Reviewed
• [Journal Article] Dose-dependent effect of the CYP2D6 genotype on the steady-state fluvoxamine concentration. (2008)
  • Author(s): Watanabe J, SuzukiY, Fukui N, Sugai T, Ono s, Inoue Y, Someya T
  • Journal Title: Ther Drag Monit 30(6) Pages: 705-708
  • Peer Reviewed
• [Journal Article] Association study of interleukin-2 (IL2)and IL4 with schizophrenia in a Japanese population. (2008)
  • Author(s): Watanabe Y, Nunokawa A, Shibuya M, Kaneko N, Nawa H, Someya T
  • Journal Title: Eur Arch Psychiatry Clin Neurosci 258(7) Pages: 422-427
  • Peer Reviewed
• [Journal Article] Mapping translational research in personalized therapeutics : From molecular markers to health policy (2007)
  • Author(s): Ozdemir V, Williams-Jones B, Cooper DM, Someya T, Godard B
  • Journal Title: Pharmacogenomics 8(2) Pages: 177-185
  • Peer Reviewed
• [Journal Article] Asymmetry in scientific method and limits to cross-disciplinary dialogue : Toward a shared language and science policy in pharmacogenomics and human disease genetics (2007)
  • Author(s): Ozdemir V, Williams-Jones B, Graham JE, Preskorn SH, Gripeos D, Glatt SJ, Fri is RH, Reist C, Szabo S, Lohr JB, Someya T
  • Journal Title: J Investig Med 55(3) Pages: 130-141
  • Peer Reviewed
• [Journal Article] No association between the ERBB3 gene schizophrenia in a Japanese Population (2007)
  • Author(s): Watanabe Y, Fukui N, Nunokawa A, Muratake T, Kaneko N, Kitamura H, Someya T
  • Journal Title: Neurosci Res 57(4) Pages: 574-578
  • NAID: 10024414100
  • Peer Reviewed
• [Journal Article] Lack of association between the interleukin-1 gene complex and schizophrenia in a Japanese population (2007)
  • Author(s): Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Koizumi M Someya T
  • Journal Title: Psychiatry Clin Neurosci 61(4) Pages: 364-369
  • Peer Reviewed
• [Journal Article] Dose-dependent effect of the 3435 C>T genotype of ABCB1 gene on the steady-state plasma concentration of fluvoxamine in psychiatric patients (2007)
  • Author(s): Fukui N, Suzuki Y, Sawamura K Sugai T, Watanabe J, Inoue Y, Someya T
  • Journal Title: Ther Drug Monit 29(2) Pages: 185-189
  • Peer Reviewed
• [Journal Article] Dose-dependent effects of the 3435C>T genotype of ABCB1 gene on the steady-state plasma concentration of fluvoxamine in psychiatric patients. (2007)
  • Author(s): Fukui N, Suzuki Y, Sawamura K, Sugai T, Watanabe J, Inoue Y, Someya T
  • Journal Title: Ther Drug Monit 29(2) Pages: 185-189
  • Peer Reviewed
• [Journal Article] Mapping translational research in personalized therapeutics: From molecular markers to health policy. (2007)
  • Author(s): Ozdemir V, Williams-Jones B, Cooper DM, Someya T, Godard B
  • Journal Title: Pharmacogenomics 8(2) Pages: 177-185
  • Peer Reviewed
• [Journal Article] Asymmetry in scientific method and limits to cross-disciplinary dialogue: Toward a shared language and science policy in pharmacogenomics and human disease genetics. (2007)
  • Author(s): Ozdemir V, Williams-Jones B, Graham JE, Preskorn SH, Gripeos D Glatt SJ, Friis RH, Reist C, Szabo S, Lohr JB, Someya T
  • Journal Title: J Invest Med 55(3) Pages: 130-141
  • Peer Reviewed
• [Journal Article] Hypoglycemia induced by second generation antipsychotic agents in non-diabetic schizophrenic Patients
  • Author(s): Suzuki Y, Watanabe J, Fukui N, Ozdemir V, Someya T
  • Journal Title: Br Med J (in press)
  • Peer Reviewed
• [Journal Article] Concentration-response relationship for fluvoxamine using remission as an endpoint: A receiver operating characteristics curve analysis in major depression.
  • Author(s): Suzuki Y, Fukui N, Sawamura K, Sugai T, Watanabe J, Ono S, Inoue Y, Ozdemir V, Someya T
  • Journal Title: J Clin Psychopharmacol (In press)
  • Peer Reviewed
• [Presentation] オランザピンがアディポカイン変化に与える影響 (2008)
  • Author(s): 須貝拓朗, 鈴木雄太郎, 福井直樹, 渡邉純蔵小野信, 常山暢人, 染矢俊幸
  • Organizer: 第18回日本臨床精神神経薬理学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-03
• [Presentation] Association study of the rheumatoid arthritis susceptible genes with schizophrenia (2008)
  • Author(s): Watanabe Y, Muratake T, Nunokawa A, Kaneko N, Someya T
  • Organizer: 2^<nd> WFSBP Asis-Pacif is Congress and 30^<th> Annual Meeting of Japanese Society of Biological Psychiatry
  • Place of Presentation: 富山
  • Year and Date: 2008-09-13
• [Presentation] Association study of the rheumatoid arthritis susceptible genes with schizophrenia (2008)
  • Author(s): Watanabe Y. Muratake T, Nunokawa A, Kaneko N, Someya T
  • Organizer: 2^<nd> WFSBP Asis-Pacific Congress and 30^<th> Annual Meeting of Japanese Society of Biological Psychiatry
  • Place of Presentation: 富山
  • Year and Date: 2008-09-13
• [Presentation] シンポジウム : SSRIによって惹起される副作用の予測は可能か? (2008)
  • Author(s): 須貝拓朗, 鈴木雄太郎, 澤村一司, 福井直樹, 渡邉純蔵, 小野信, 井上義政, 染矢俊幸
  • Organizer: 第104回日本精神神経学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-29
• [Presentation] Pharmacogenomics and customized therapies in psychiatry (2008)
  • Author(s): Someya T
  • Organizer: 14th Meeting of Pacific Rim Assoc iat ion for Clinical Pharmacogenetics
  • Place of Presentation: Busan
  • Year and Date: 2008-04-10
• [Presentation] Symposium : Pharmacogenomics and customized therapies in psychiatry. (2008)
  • Author(s): Someya T
  • Organizer: 14^<th> Meeting of Pacific Rim Association for Clinical Pharmacogenetics
  • Place of Presentation: Busan
  • Year and Date: 2008-04-10
• [Presentation] CYP2C19遺伝子多型が定常状態fluvoxamine血中濃度に与える影響 (2007)
  • Author(s): 鈴木雄太郎, 福井直樹, 渡邉純蔵, 澤村一司, 須貝拓朗, 小野信, 熊田智, 井上義政, 染矢俊幸
  • Organizer: 第17回日本臨床精神神経薬理学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-04
• [Presentation] 悪性症候群とドーパミンD3受容体遺伝子多型との関連研究 (2007)
  • Author(s): 須貝拓朗, 鈴木雄太郎, 福井直樹, 澤村一司, 渡邉純蔵, 小野信, 熊田智, 染矢俊幸
  • Organizer: 第29回日本生物学的精神医学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-07-13
• [Book] 統合失調症の薬物療法1GOのQ&A (2008)
  • Author(s): 渡邉純蔵, 福井直樹, 鈴木雄太郎, 染矢俊幸
  • Publisher: 星和書店
• [Book] 統合失調症の100のQ&A (藤井康男編) (2008)
  • Author(s): 渡邉純蔵, 福井直樹, 鈴木雄太郎, 染矢俊幸
  • Publisher: 星和書店, 東京
• [Book] 統合失調症の治療(佐藤光源,丹羽真一,井上新平編) (2007)
  • Author(s): 染矢俊幸, 高橋誠
  • Publisher: 朝倉書店
• [Book] SSRIの薬物動態と代謝-フルボキサミン, パロキセチンを中心に-.SSRIのすべて(小山司編) (2007)
  • Author(s): 須貝拓朗, 澤村一司, 染矢俊幸
  • Publisher: 先端医学社,東京