| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Our investigation revealed lower FA in various white matter regions that implies the disruption of white matter integrity in schizophrenia patients. In the patient group, the FA value of the anterior part of the corpus callosum was negatively correlated with the severity of negative symptoms. In the study using the voxel-based diffusion tensor imaging, ARMS had mild structural brain change compared to first episode schizophrenia patients. This finding was ascribed to the fact that ARMS included people with prodromal signs of psychosis who developed psychosis later and had not. Our longitudinal study with manual tracing method, schizophrenia patients exhibit progressive gray matter reductions associated with overt psychosis in the early years of the illness.
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