Elucidation of brain morphological change and functional change at risk mental state
| Project/Area Number |
19591346
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Michio 富山大学, 大学院・医学薬学研究部(医学), 教授 (40236013)
KAWASAKI Yasuhiro 富山大学, 大学病院, 講師 (80242519)
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| Project Period (FY) |
2007 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 精神生理学 / こころのリスク状態(ARMS) / 統合失調症 / 前駆状態 / 3次元MR画像 / 拡散テンソル画像 |
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| Research Abstract |
Our investigation revealed lower FA in various white matter regions that implies the disruption of white matter integrity in schizophrenia patients. In the patient group, the FA value of the anterior part of the corpus callosum was negatively correlated with the severity of negative symptoms. In the study using the voxel-based diffusion tensor imaging, ARMS had mild structural brain change compared to first episode schizophrenia patients. This finding was ascribed to the fact that ARMS included people with prodromal signs of psychosis who developed psychosis later and had not. Our longitudinal study with manual tracing method, schizophrenia patients exhibit progressive gray matter reductions associated with overt psychosis in the early years of the illness.
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Report
(6 results)
Research Products
(26 results)
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[Journal Article] Longitudinal volume changes of the pituitary gland in patients with schizotypal disorder and first-episode schizophrenia2011
Author(s)
Takahashi T, Zhou SY, Nakamura K, Tanino R, Furuichi A, Kido M, Kawasaki Y, Noguchi K, Seto H, Kurachi M, Suzuki M.
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Journal Title
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume: 35
Pages: 177-183
Related Report
Peer Reviewed
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[Journal Article] A follow-up MRI study of the fusiform gyrus and middle and inferior temporal gyri in schizophrenia spectrum2011
Author(s)
Takahashi T, Zhou SY, Nakamura K, Tanino R, Furuichi A, Kido M, Kawasaki Y, Noguchi K, Seto H, Kurachi M, Suzuki M.
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Journal Title
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume: 35
Pages: 1957-1964
Related Report
Peer Reviewed
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[Journal Article] Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables2010
Author(s)
Takayanagi Y, Kawasaki Y, Nakamura K, Takahashi T, Orikabe L, Toyoda E, Mozue Y, Sato Y, Itokawa M, Yamasue H, Kasai K, Kurachi M, Okazaki Y, Matsushita M, Suzuki M.
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Journal Title
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume: 34
Pages: 10-17
Related Report
Peer Reviewed
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