sensorimotor gating processing in autistic disorder ; functional magnetic resonance imaging study

• Project/Area Number: 19591348
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: TAKEBAYASHI Kiyokazu Hamamatsu University School of Medicine, 医学部・附属病院, 助教 (50397428)
• Co-Investigator(Kenkyū-buntansha): SUDA Shiro 浜松医科大学, 医学部, 助教 (40432207) ; YAMAMOTO Shigeyuki 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (10382201) ; IWATA Yasuhide 浜松医科大学, 医学部, 助教 (10285025) ; MATSUZAKI Hideo 大阪大学, 医学系研究科, 特任准教授(常勤) (00334970) ; ISODA Haruo 浜松医科大学, 医学部, 准教授 (40223060) ; TSUJII Masatsugu 浜松医科大学, 子どものこころの発達研究センター, 客員教授 (20257546) ; TAKEI Noriyoshi 浜松医科大学, 子どものこころの発達研究センター, 特任教授 (80206937) ; SUGIHARA Genichi 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (70402261) ; SAKAHARA Harumi 浜松医科大学, 医学部, 教授 (10187031)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2007: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
• Keywords: PPI / 感覚運動入力 / 自閉性障害 / プレパルスインヒビション / 自閉症 / 機能的核磁気共鳴画像

Research Abstract

本研究では自閉性障害での感覚運動入力の障害を触覚でも検出するための機器を製作した。健常者19名における触覚のPPIを測定した結果、被験者間での個体差の少ない均質なデータが得られた。今後、自閉性障害への応用が期待される。

Research Products

• [Journal Article] resonance imaging(MRI)study of patients with early onset schizophrenia (2008)
  • Author(s): Yoshihara Y, Sugihara G, Matsumoto H, Suckling J,Nishimura K, Toyoda T, Isoda H, Tsuchiya KJ, Takebayashi K, Suzuki K, Sakahara H, Nakamura K, Mori N, Takei N.
  • Journal Title: Ann Gen Psychiatry 7 Pages: 25-25
  • Peer Reviewed
• [Journal Article] Short allele of 5-HTTLPR as a risk factor for the development of psychosisin Japanese methamphetamine abusers (2008)
  • Author(s): Ezaki N, Nakamura K, Sekine Y, Thanseem I, Anitha A, Iwata Y, Kawai M, Takebayashi K, Suzuki K, Takei N, Iyo M, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Mori N.
  • Journal Title: Mori N.Ann N Y Acad Sci 1139 Pages: 49-56
  • Peer Reviewed
• [Journal Article] Methamphetamine causes microglial activation in the brains of human abusers (2008)
  • Author(s): Sekine Y, Ouchi Y, Sugihara G, Takei N, Yoshikawa E, Nakamura K, Iwata Y, Tsuchiya KJ, Suda S, Suzuki K, Kawai M, Takebayashi K, Yamamoto S, Matsuzaki H, Ueki T, Mori N.
  • Journal Title: Gold MS, Cadet JL. J Neurosci 28 Pages: 5756-5761
  • Peer Reviewed
• [Journal Article] Voxel-based structural magnetic resonance imaging (MRI) study of patients with early onset schizophrenia. (2008)
  • Author(s): Yoshihara Y
  • Journal Title: Ann Gen Psychiatry 7 Pages: 25-25
  • Peer Reviewed
• [Journal Article] Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese meth amphetamine abusers. (2008)
  • Author(s): Ezaki N
  • Journal Title: Ann N Y Acad Sci 1139 Pages: 49-56
  • Peer Reviewed