Development of biological marker of panic disorder

• Project/Area Number: 19591349
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Mie University
• Principal Investigator: TANII Hisashi Mie University, 大学院・医学系研究科, 准教授 (40346200)
• Co-Investigator(Kenkyū-buntansha): NISHIMURA Yukika 三重大学, 大学院・医学系研究科, リサーチアソシエイト (60456738) ; NAKAGAWA Masanori 三重大学, 大学院・医学系研究科, 助教 (20456726) ; KASHIMOTO Kanae 三重大学, 医学部・附属病院, 医員 (00378390)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: パニック障害 / 診断マーカー / コレステロール / 前頭葉機能 / COMTVal158Met 多型 / Trait marker / State marker / 生物学的診断マーカー / 生物学的診療マーカー

Research Abstract

パニック障害においてモノアミン関連酵素(MAOA)と血清コレステロール値との関連が見出され(特に男性)、発症年齢とパニック発作時の症状数など重症度との関連や家族内発症が影響が示された。その他、合併症としては広場恐怖やうつ病の合併が疾患としての重症度を高めることも示された。診断マーカー候補の一つとして光トポグラフィー(NIRS)を用いた前頭葉機能の検討を行い、前頭前皮質内側部についてパニック障害のTrait marker、罹患者のみで賦活の低下を認めた前頭葉外側部についてはState marker となる可能性が示された。またCOMTVal158Met 多型において左前頭葉での賦活の相違が認められ、疾患群における自律神経症状との対応が考えられた。

Research Products

• [Journal Article] Asymmetry ofprefrontal cortex activities andcatechol-O-methyltransferase Val158Metgenotype in patients with panic disorderduring a verbal fluency task: near infraredspectroscopy study (2009)
  • Author(s): Tanii H, Nishimura Y, Inoue K, Koshimizu H, Matsumoto R, Takami T, Hara N, Nishida A, Okada M, Kaiya H, Okazaki Y
  • Journal Title: Neuroscience Letters 452 Pages: 63-67
  • Peer Reviewed
• [Journal Article] Genome-wideassociation study of panic disorder in theJapanese population (2009)
  • Author(s): Otowa T, Yoshida E, Yasuda S, Sugaya N, Nishimura Y, Inoue K, Tochigi M, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Tanii H,Sasaki T, Kaiya H, Okazaki Y
  • Journal Title: J Hum Genet 54 Pages: 122-126
  • Peer Reviewed
• [Journal Article] Specific panic attack symptoms in panicdisorder patients with putative genetic factor (2009)
  • Author(s): Nishimura Y, Tanii H, Hara N, Inoue K, Nishida A, Okada M, Kaiya H, Okazaki Y
  • Journal Title: Psychiatry and Clinical Neurosciences 63 Pages: 251-252
  • Peer Reviewed
• [Journal Article] Asymmetry of prefrontal cortex activities and catechol-O-methylransferase Val158Met genotype in patients with panic disorder during a verbal fluency task : near infrared spectroscopy study. (2009)
  • Author(s): Tanii H, Nishimura Y, et al
  • Journal Title: Neuroscience Letters 452 Pages: 63-67
  • Peer Reviewed
• [Journal Article] Specific panic attack symptoms in panic disorder patients with putative genetic factor (2009)
  • Author(s): Nishimura Y, Tanii H, et al
  • Journal Title: Psychiatry and Clinical Neurosciences 63 Pages: 251-252
  • Peer Reviewed
• [Journal Article] Relationship between the prefrontal function during a cognitive task and the severity of the symptoms in patients with panic disorder : a multi-channel NIRS study. (2009)
  • Author(s): Nishimura Y, Tanii H, et al
  • Journal Title: Psychiatry Research-Neuroimaging 172 Pages: 168-172
  • Peer Reviewed
• [Journal Article] Genome-wide association study of panic disorder in the Japanese population. (2009)
  • Author(s): Otowa T, Tanii H, et al
  • Journal Title: J Hum Genet 54 Pages: 122-126
  • Peer Reviewed
• [Journal Article] Appropriate data cleaning methods forgenome-wide association study (2008)
  • Author(s): Miyagawa T, Nishida N, Ohashi J, Kimura R,Fujimoto A, Kawashima M, koike A, Sasaki T,Tanii H, Otowa T, Momose Y, Nakahara Y,Gotoh J, Okazaki Y, Tsuji S, Tokunaga K
  • Journal Title: Journal of Human Genetics 53(10) Pages: 886-893
  • Peer Reviewed
• [Journal Article] The riskfactors of suicide by poisoning amongpsychiatry department outpatients (2008)
  • Author(s): Inoue K, Tanii H, Abe S, Nishimura Y, Kaiya H, Okazaki Y, Nata M, Fukunaga T
  • Journal Title: Journal of Forensic and Legal Medicine 15 Pages: 65-67
  • Peer Reviewed
• [Journal Article] Appropriate data cleaning methods for genome-wide association study. (2008)
  • Author(s): Miyagawa T, Tanii H, et al
  • Journal Title: J Hum Genet 53 Pages: 886-893
  • Peer Reviewed
• [Journal Article] Associations between psychotic-like ecperiences and mental health stauts and other psychopathologies among Japnese early teens. (2008)
  • Author(s): Nishida A, Tanii H, et al
  • Journal Title: Schizophr Res 99 Pages: 125-133
  • Peer Reviewed
• [Journal Article] Suicide in panic disorder (2008)
  • Author(s): Inoue K, Tanii H, et. al.
  • Journal Title: International Medical Journal 14(3) Pages: 199-202
  • Peer Reviewed
• [Journal Article] Kaiya H Suicide in panic disorder -Review- (2007)
  • Author(s): Inoue K, Tanii H, Nishimura Y, Masaki M, Yokoyama C, Kajiki N, Nishida A, Fukunaga T, Nata M, Abe S, Okazaki Y
  • Journal Title: International Medical Journal 14 Pages: 199-202
  • Peer Reviewed
• [Journal Article] The significant correlation of psychiatric disorders with leaves of absence among teachers in Japan Psychiatry and Clinical Neurosciences (2007)
  • Author(s): Inoue K, Tanii H, Kaiya H, Nata M, Fukunaga T, Okazaki Y
  • Journal Title: 61 Pages: 334-334
  • Peer Reviewed
• [Journal Article] The risk for suicide in Japan -Review- (2007)
  • Author(s): Inoue K, Tanii H, Kaiya H, Abe S, Fujita Y, Masaki M, Okazaki Y, Nata M, Fukunaga T
  • Journal Title: International Medical Journal 14 Pages: 203-206
  • Peer Reviewed
• [Journal Article] The significant correlation between increases in suicide rates and increases in male unemployment rates in Mie Prefecture, Japan, between 1995 and 2002 (2007)
  • Author(s): Inoue K, Tanii H, Abe S, Kaiya H, Nata M, Okazaki Y, Fukunaga T
  • Journal Title: International Medical Journal 14 Pages: 287-289
  • Peer Reviewed
• [Journal Article] 第28回日本生物学的精神医学会シンポジウム 特集I : 不安障害の生物学 : 最前線(1)パニック障害の遺伝子探索 (2007)
  • Author(s): 谷井久志、井上 顕、西村幸香、梶木直美、貝谷久宣、佐々木司、岡崎祐士
  • Journal Title: 脳と精神の医学3月号特集 Vol.18(1) Pages: 1-7
  • Peer Reviewed
• [Journal Article] パニック障害の遺伝子探索 (2007)
  • Author(s): 谷井久志、井上顕、梶木直美、西村幸香、貝谷久宣、佐々木司、岡崎祐士
  • Journal Title: 脳と精神の医学 18巻2号 Pages: 115-126
  • NAID: 10029854062
• [Journal Article] Frontal dysfunction during a cognitive task in drug-naive patients with panic disorder as investigated by multi-channel near-infrared spectroscopy imaging, (2007)
  • Author(s): Nishimura Y, Tanii H, et. al.
  • Journal Title: Neuroscience Research 59(1) Pages: 107-112
  • NAID: 10024417060
  • Peer Reviewed
• [Journal Article] The risk for suicide in Japan (2007)
  • Author(s): Inoue K, Tanii H, et. al.
  • Journal Title: International Medical Journal 14(3) Pages: 203-206
  • Peer Reviewed
• [Journal Article] Noassociation between the brain-derivedneurotrophic factor gene and panic disorder in Japanese population
  • Author(s): Otowa T, Shimada T, Kawamura Y, Liu X,Inoue K, Sugaya N, Minato T, Nakagami R,Tochigi M, Umekage T, Kasai K, Kato N,Tanii H, Okazaki Y, Kaiya H, Sasaki T
  • Journal Title: J Hum Genet (in press)
  • Peer Reviewed
• [Journal Article] Intrasubjectreproducibility of prefrontal cortex activitiesduring averbal fluency task over two repeatedsessions using multi-channelnear-infraredspectroscopy
  • Author(s): Kakimoto Y, Nishimura Y, Hara N, Okada M, Tanii H, Okazaki Y
  • Journal Title: Psychiatry and Clinical Neurosciences (in press)
  • Peer Reviewed
• [Journal Article] Effects of zotepine on extracellular levels of monoamine
  • Author(s): Yamamura S, Ohoyama K, Hamaguchi T,Nakagawa M, Suzuki D, Matsumoto T,Motomura E, Tanii H, Shiroyama T, Okada M
  • Journal Title: GABA and glutamate in ratprefrontal cortex. Br J Pharmcol (in press)
  • Peer Reviewed
• [Journal Article] Relationship between the prefrontal functionduring a cognitive task and the severity of thesymptoms in patients with panic disorder: amulti-channel NIRS study
  • Author(s): Nishimura Y, Tanii H, Hara N, Inoue K, Kaiya H, Nishida A, Okada M, Okazaki Y
  • Journal Title: Psychiatry Research - Neuroimaging (in press)
  • Peer Reviewed
• [Journal Article] Frontal lobe dysfunction in panicdisorder: a comparison of multichannnelnear-infrared spectroscopy in monozygotictwins discordant for panic disorder
  • Author(s): Tanii H, Nishimura Y, Inoue K, Hara N, Nishida A, Okada M, Imamura A, Kaiya H, Okazaki Y
  • Journal Title: TheJournal of Neuropsychiatry and Clinical Neurosciences (in press)
  • Peer Reviewed
• [Journal Article] Improvement of total health measures in Mie Prefecture
  • Author(s): Inoue K, Tanii T, Konishi Y, Hara N, Matsumoto T, Nata M
  • Journal Title: Japan. West Indian Med Journal (in press)
  • Peer Reviewed
• [Journal Article] Topiramate andzonisamide prevent paradoxical intoxicationinduced by carbamazepine and phenytoin
  • Author(s): Yamamura S, Hamaguchi T, Ohoyama K, Sugiura Y, Suzuki D, Kanehara S, Nakagawa M, Motomura E, Matsumoto T, Tanii H, Shiroyama T, Okada M
  • Journal Title: Epilepsy Res (in press)
  • Peer Reviewed
• [Journal Article] Frontal lobe dysfunction in panic disorder : a comparison of multichannnel near-infrared spectroscopy in monozygotic twins discordant for panic disorder.
  • Author(s): Tanii H, Nishimura Y, et al
  • Journal Title: J Neuropsychiatry Clinical Neurosciences (印刷中)
  • Peer Reviewed
• [Presentation] Does the place of the first panic attack predict future comorbid agoraphobia (2008)
  • Author(s): Naomi Hara, Yukika Nishimura, Hisashi Tanii, Ken Inoue, Atsushi Nishida, Chika Yokoyama1, Motohiro Okada, Hisanobu Kaiya, Yuji Okazaki
  • Organizer: XIV World Congress of Psychiatry(WPA)
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2008-09-23
• [Presentation] Does the place of the first panic attack predict future comorbid agoraphobia? (2008)
  • Author(s): Naomi Hara, Yukika Nishimura, Hisashi Tanii, et al
  • Organizer: XIV World Congress of Psychiatry
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2008-09-23
• [Presentation] Association of the functional -1019C/G 5-HT1A polymorphism with prefrontal cortex activation investigated by multi-channel near-infrared spectroscopy imaging in panic disorder (2008)
  • Author(s): Hisashi Tanii, Ryusuke Matsumoto, Yukika Nishimura, Ken Inoue, Tsukasa Sasaki, Takeshi Otowa, Motohiro Okada, Hisanobu Kaiya, Yuji Okazaki
  • Organizer: XVIth World Congress on Psychiatric Genetic
  • Place of Presentation: Osaka
• [Presentation] Risk genes for panic disorder: a GWAS study (2008)
  • Author(s): Hisashi Tanii, Tsukasa Sasaki, Takeshi Otowa, Tadafumi Kato, Takeo Yoshikawa, Tadao Arinami, Hiroshi Kunugi, Toshiyuki Someya, Naomichi Matsumoto, Hisanobu Kaiya, Yuji Okazaki
  • Organizer: 51th Annual Conference of the Japanese Society for Neurochemistry
  • Place of Presentation: Toyama
• [Presentation] Genome-wide association study of panic disorder in Japanese (2008)
  • Author(s): Yuji Okazaki, Tsukasa Sasaki, Hisashi Tanii, Hisanobu Kaiya
  • Organizer: 2008 International Conference on Pharmacogenetics
  • Place of Presentation: Busan, Korea
• [Presentation] Association of the functional -1019C/G 5-HT1A polymorphism with prefrontal cortex activation investigated by multi-channel nearinfrared spectroscopy imaging in panic disorder (2008)
  • Author(s): Hisashi Tanii, Ryusuke Matsumoto, et al
  • Organizer: Vlth World Congress on Psychiatric Genetic
  • Place of Presentation: 大阪
• [Presentation] Risk genes for panic disorder : a GWAS study (2008)
  • Author(s): Hisashi Tanii, Tsukasa Sasaki, et al
  • Organizer: 51th Annual Conference of the Japanese Society for Neurochemistry
  • Place of Presentation: 富山
• [Presentation] Genome-wide association study of panic disorder in Japanese (2008)
  • Author(s): Okazaki Y, Tsukasa Sasaki, Hisashi Tanii, et al
  • Organizer: 2008 International Conference on Pharmacogenetics
  • Place of Presentation: プサン(韓国)
• [Presentation] パニック障害患者における初発パニック発作症痺の遺伝学的検討 (2007)
  • Author(s): 高見 鉄平、西村 幸香、谷井 久志, 他
  • Organizer: 第1回日本精神・行動遺伝医学会
  • Place of Presentation: 東京・精神神経センター
  • Year and Date: 2007-11-17
• [Presentation] 第一度血縁者に同種疾患を有するパニック障害患者における初発パニック発作症状の特徴 (2007)
  • Author(s): 西村 幸香、谷井 久志, 他
  • Organizer: 第27回日本精神科診断学会
  • Place of Presentation: 徳島・'徳島県郷土文化会館
  • Year and Date: 2007-10-13
• [Presentation] パニック障害に関する一卵性双生児不一致ペアに関する検討 (2007)
  • Author(s): 谷井 久志, 他
  • Organizer: 第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
  • Place of Presentation: 札幌・国際会議場
  • Year and Date: 2007-07-12
• [Presentation] パニック障害患者における初発パニック発作症状の遺伝学的検討 (2007)
  • Author(s): 高見鉄平、西村幸香、谷井久志、貝谷久宣、岡崎祐士
  • Organizer: 第15回日本精神・行動遺伝医学会
  • Place of Presentation: 東京
• [Presentation] 第一度血縁者に同種疾患を有するパニック障害患者における初発パニック発作症状の特徴 (2007)
  • Author(s): 西村幸香、谷井久志、井上顕、梶木直美、貝谷久宣、岡崎祐士
  • Organizer: 第27回日本精神科診断学会
  • Place of Presentation: 徳島
• [Presentation] 近赤外線スペクトロスコピーを用いた語流暢性課題における経時的変化の検討 (2007)
  • Author(s): 柿本優、西村幸香、谷井久志、岡崎祐士
  • Organizer: 第27回日本精神科診断学会
  • Place of Presentation: 徳島
• [Presentation] パニック障害に関する一卵性双生児不一致ペアに関する検討 (2007)
  • Author(s): 谷井久志、井上顕、西村幸香、横山知加、加藤忠史、岡田元宏、貝谷久宣、 岡崎祐士
  • Organizer: 第29回日本生物学的精神医学会・第37 回日本神経精神薬理学会合同年会
  • Place of Presentation: 札幌
• [Presentation] パニック障害における語流暢課題遂行時の局所脳血流量変化 : 波形パターンの特徴 (2007)
  • Author(s): 西村幸香、谷井久志、梶木直美、井上顕、西田淳志、貝谷久宣、 岡田元宏、岡崎祐士
  • Organizer: 第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
  • Place of Presentation: 札幌
• [Book] 「パニック障害の治療ガイドライン」第3章 診断と評価 (2009)
  • Author(s): 谷井久志, 原直美, ほか
  • Publisher: 医学書院
• [Book] パニック障害の治療ガイドライン(第3章診断と評価) (2008)
  • Author(s): 谷井久志、梶木直美、西村幸香、貝谷久宣、岡崎祐士
  • Publisher: 医学書院
• [Book] 脳神経疾患研究の最前線(5章-3)パニック障害(25巻13号) (2007)
  • Author(s): 谷井久志、佐々木司、音羽健司、西村幸香、貝谷久宣、岡崎祐士
  • Publisher: 実験医学
• [Book] 「脳神経疾患研究の最前線」5章-3「パニック障害」実験医学増刊号25巻13号(共著) (2007)
  • Author(s): 谷井 久志、佐々木 司, 他
  • Publisher: 羊土社