Investigation about the treatment of autism spectrum disorder using Animal model for autism.
| Project/Area Number |
19591350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nara Medical University |
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Principal Investigator |
SADAMATSU Miyuki Nara Medical University, 医学部, 准教授 (90252387)
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| Co-Investigator(Kenkyū-buntansha) |
KANAI Hirohiko 滋賀医科大学, 医学部, 講師 (30293830)
黒川 清 環太平洋大学, 体育学部, 教授 (40215083)
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| Co-Investigator(Renkei-kenkyūsha) |
MAKINODAN Manabu 奈良県立医科大学, 医学部, 助教 (00510182)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 自閉症 / 甲状腺ホルモン / セロトニン / 小脳 / カテコールアミン / ノックアウトマウス / 行動解析 |
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| Research Abstract |
I investigated about the possibility as the potential animal model for autism with operating thyroid hormone which plays an important role in the development of central nervous system. In the open-field tests, thyroid hormone β receptor knockout (TRβ(-/-)) mice exhibited a significant increase in locomotor activation. HPLC analysis revealed that TRβ(-/-) mice displayed a significant increase of dopamine concentrations in the striatum as well as in the nucleus accumbens. It was suggested that TRβ(-/-) mice might be as a potential animal model for attention-deficit hyperactivity disorder.
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Report
(4 results)
Research Products
(4 results)
