| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Mice homozygous for a mutation in pericentrin gene displayed malformation of primary cilia in the CNS and olfactory cilia of olfactory receptor neurons. There was no significant difference in locomotion, anxiety-related behavior and neurogenesis in the subgranular zone of hippocampal dentate gyrus between homozygous mutant mice and wild-type mice. On the other hand, the mutant mice displayed behavioral alterations of an anti-depressive phenotype in addition to reduced olfactory performance, suggesting malformation of primary cilia in the CNS led to an anti-depressive effect.
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