Functional analysis of primary cilia in the CNS using pericentrin mutant mice
Project/Area Number |
19591355
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Psychiatric science
|
Research Institution | Okayama University |
Principal Investigator |
MIYOSHI Ko Okayama University, 大学院・医歯薬学総合研究科, 助教 (90362996)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 繊毛 / 中心体 / 中枢神経系 |
Research Abstract |
Mice homozygous for a mutation in pericentrin gene displayed malformation of primary cilia in the CNS and olfactory cilia of olfactory receptor neurons. There was no significant difference in locomotion, anxiety-related behavior and neurogenesis in the subgranular zone of hippocampal dentate gyrus between homozygous mutant mice and wild-type mice. On the other hand, the mutant mice displayed behavioral alterations of an anti-depressive phenotype in addition to reduced olfactory performance, suggesting malformation of primary cilia in the CNS led to an anti-depressive effect.
|
Report
(4 results)
Research Products
(30 results)