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Analysis of mental disorders using leukocyte mRNA expression

Research Project

Project/Area Number 19591357
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionEhime University (2008)
The University of Tokushima (2007)

Principal Investigator

UENO Shuichi  Ehime University, 大学院・医学系研究科, 教授 (80232768)

Co-Investigator(Kenkyū-buntansha) OMORI Tetsuro  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00221135)
NUMATA Shusuke  徳島大学, 医学部・歯学部附属病院, 助教 (10403726)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords神経化学 / 脳・神経 / ストレス / ゲノム / マイクロアレイ / 統合失調症 / うつ病 / 末梢血白血球 / mRNA発現解析 / 疾患対照関連解析 / PDE4B遺伝子 / PCNT2遺伝子 / 性周期 / 遺伝子発現解析 / 遺伝子関連解析 / HDAC5 / CREB / VEGF / TGFBR2
Research Abstract

機能性精神障害(統合失調症、気分障害など)を対象に、末梢血白血球遺伝子発現を指標にして病因候補遺伝子を抽出し、候補遺伝子との相関研究を行った。その結果、末梢血白血球のmRNA量は、統合失調症では、PDLIM5およびTGFBR2遺伝子発現量が、うつ病では、HDAC5およびCREB、VEGF遺伝子発現量が変化しており、状態像を示す候補遺伝子マーカーとして挙げられた。一方、疾患対照相関解析から、統合失調症ではPDE4B遺伝子、うつ病ではPCNT2遺伝子が、その発症の脆弱性に関与する疾患特異的マーカーと思われた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (24 results)

All 2009 2008 2007 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (4 results)

  • [Journal Article] Positive Association of The PDE4B (Phosphodiesterase 4B) gene with Schizophrenia in the Japanese Population.2009

    • Author(s)
      S. Numata, S. Ueno, J. Iga, S. Hongwei, M. Nakataki, S. Tayoshi, S. Sumitani, M. Tomotake, M. Itakura, A. Sano, T. Ohmori
    • Journal Title

      J Psychiatric Res 43

      Pages: 7-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Positive Association of The PDB4B(Phosphodie sterase4B)gene with Schizophrenia in the Japanese Population2009

    • Author(s)
      S. Numata, S. Ueno, J. Iga, 他
    • Journal Title

      J Psychiatric Res 43

      Pages: 7-12

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Positive Association of the PCNT2 gene with Major Depressive Disorder in tie Japanese Population2009

    • Author(s)
      S. Numata, J. Ige, M Nakataki, 他
    • Journal Title

      J Psychiatry Neurosci (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression and association analyses of the PDE4B (Phosphodiesterase 4B)gene in major depressive disorder in the Japanese Population2009

    • Author(s)
      S. Numata, J. Iga, M. Nakataki, 他
    • Journal Title

      Am J Med Genet (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FKBP5, SERT and COMT mRNA expressions in the peripheral leukocytes during menstruation cycle in healthy reproductive females2008

    • Author(s)
      S. Kinouchi, J. Iga, S. Ueno, K. Yamauchi, S. Numata, H. Song, S. Sumitani, S. Shibuya-Tayoshi, M. Haku, T. Yasui, M. Irahara, K. Morita, K. Rokutan, T. Ohmori.
    • Journal Title

      Neurosci Lett 434

      Pages: 124-128

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular assessment of depression from mRNAs in the peripheral leukocytes2008

    • Author(s)
      J. Iga, S. Ueno, T. Ohmori
    • Journal Title

      Annals of Medicine 40

      Pages: 336-342

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] No association between the NDE1 gene and schizophrenia in the Japanese Population.2008

    • Author(s)
      S. Numata, S. Ueno, J. Iga, M. Nakataki, T. Tanahashi, M. Itakura, A. Sano, K. Ohi, R. Hashimoto, M. Takeda, T. Ohmori
    • Journal Title

      Schizophr Res 99

      Pages: 367-369

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noassociation between the NDEl gene and schizophrenia in the Japanese Population.2008

    • Author(s)
      S. Numata, S. Ueno, J. Iga, 他
    • Journal Title

      Schizophr Res 99

      Pages: 367-369

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FKBP5, SERT and COMTmRNA expressions in the peripheral leukocytes during menstruation cycle in healthy reproductive females.2008

    • Author(s)
      S. Kinouchi, J. lga, S. Ueno, K. Yamauchi, 他
    • Journal Title

      Neurcsci Lett 434

      Pages: 124-128

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between PNPO and schizophrenia in the Japanese population2007

    • Author(s)
      H. Song, S. Ueno, S. Numata, J. Iga, S. Shibuya-Tayoshi, M. Nakataki, S. Tayoshi, K. Yamauchi, S. Sumitani, T. Tomotake, T. Tada, T. Tanahashi, M. Itakura, T. Ohmori
    • Journal Title

      Schizophr Res 97

      Pages: 264-270

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] TGFBR2 gene expression and genetic association with schizophrenia2007

    • Author(s)
      S. Numata S, S. Ueno, J. Iga, K. Yamauchi, H. Song, R. Hashimoto, M. Takeda, H. Kunugi, M. Itakura, T. Ohmori.
    • Journal Title

      J Psychiatr Res 42

      Pages: 425-432

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients2007

    • Author(s)
      J. Iga J, S. Ueno, K. Yamauchi, S. Numata, S. Tayoshi-Shibuya, S. Kinouchi, M. Nakataki, H. Song, K. Hokoishi, H. Tanabe, A. Sano, T. Ohmori.
    • Journal Title

      Am J Med Genet 144B

      Pages: 1003-1006

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia.2007

    • Author(s)
      S. Numata, S. Ueno, J. Iga, K. Yamauchi, S. Hongwei, S. Kinouchi, Hashimoto R, Takeda M, Kunugi H, Itakura M, T. Ohmori
    • Journal Title

      Neurosci Lett 415

      Pages: 28-33

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression and association analysis of vascular endothelial growth factor in major depressive disorder.2007

    • Author(s)
      J. Iga, S. Ueno, K. Yamauchi, S. Numata, S. Tayoshi, S. Kinouchi, M. Nakataki, H. Song, K. Hokoishi, H. Tanabe, T. Ohmori
    • Journal Title

      Progress Neuro-Psychopharmacol Biological Psychiat 31

      Pages: 658-663

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression.2007

    • Author(s)
      J. Iga, S. Ueno, K. Yamauchi, S. Numata, S. Kinouchi, S. Tayoshi, H. Song, T. Ohmori
    • Journal Title

      Progress Neuro-Psychopharmacol Biological Psychiatry 31

      Pages: 628-632

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered HDACS and CREB mRNA expressions in the peripheral leukocytes of major depression2007

    • Author(s)
      J Iga, et. al.
    • Journal Title

      Prog Neuro-Psychopharmacol Biol Psychiatry 31

      Pages: 628-632

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression and association analysis of vascular endothelial growth factor in major depressive disorder.2007

    • Author(s)
      J Iga, et. al.
    • Journal Title

      Prog Neuro-Psychopharmacol Biol Psychiatry 31

      Pages: 658-663

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia2007

    • Author(s)
      S. Numata, et. al.
    • Journal Title

      Neurosci Lett 415

      Pages: 28-33

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Positive Association of the PCNT2 gene with Major Depressive Disorder in the Japanese Population

    • Author(s)
      S. Numata, J. Iga, M. Nakataki, S. Tayoshi, T. Tanahashi, M. Itakura, S. Ueno, T. Ohmori
    • Journal Title

      J Psychiatry Neurosci (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression and association analyses of the PDE4B (Phosphodiesterase 4B) gene in major depressive disorder in the Japanese Population

    • Author(s)
      S. Numata, J. Iga, M. Nakataki, S. Tayoshi, K. Taniguchi, S. Sumitani, M. Tomotake, T. Tanahashi, M. Itakura, Y. Kamegaya, M. Tatsumi, A. Sano, T. Asada, H. Kunugi, S. Ueno, T. Ohmori
    • Journal Title

      Am J Med Genet (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Gene expression and association analysis of vascular endothelial growth factor in major depressive disorder2007

    • Author(s)
      M. Nakataki, J. Iga, S. Ueno, K. Yamauchi, S. Numata, S. Tayoshi-Shibuya, S. Kinouchi, H. Song, K. Hokoishi, H. Tanabe, A. Sano, T. Ohmori.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, CA USA
    • Year and Date
      2007-11-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Positive association of the PDE4B (Phosphodiesterase 4B) gene with schizophrenia and major depressive disorder in Japanese population.2007

    • Author(s)
      S. Numata, S. Ueno, J. Iga, S. Hongwei, M. Nakataki, M. itakura, A. Sano, T. Ohmori.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, CA USA
    • Year and Date
      2007-11-15
    • Related Report
      2008 Final Research Report
  • [Presentation] TGFBR2 gene expression and genetic association with schizophrenia2007

    • Author(s)
      S. Numata, et, al.
    • Organizer
      Society for Neurosience
    • Place of Presentation
      米国サンディエゴ
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] うつ病の心因、内因、器質因 : うつ病を遺伝子から考える2007

    • Author(s)
      上野修一、伊賀淳一、沼田周助、宋鴻偉、田吉伸哉、中滝理仁、山内健、大森哲郎
    • Organizer
      日本精神神経学会
    • Place of Presentation
      シンポジウム 高知
    • Year and Date
      2007-05-19
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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