Vulnerability of oligodendrocyte to DNA damages-Association with aging and dementia-

• Project/Area Number: 19591358
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kagawa University
• Principal Investigator: NAKAMURA Yu Kagawa University, 医学部, 教授 (70291440)
• Co-Investigator(Kenkyū-buntansha): ITO Kouichi 徳島文理大学, 薬学部, 教授 (30291149) ; MORI Toshio 奈良県立医科大学, 医学部, 准教授 (10115280) ; 安藤 延男 香川大学, 医学部附属病院, 助教 (80380161) ; 二宮 貴至 香川大学, 医学部, 助教 (90363192)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: オリゴデンドロサイト / NER / DNA損傷修復 / 分化 / 脆弱性 / アストロサイト / 神経細胞 / 無血清培地 / アウトロサイト / DNA損傷 / 老化 / 認知症 / 修復

Research Abstract

Neurobasalを主とした無血清培地にて安定にオリゴデンドロサイトを培養が可能であることがわかった。次に、NERによる修復されるDNA損傷特異的な抗体を用いることにより、オリゴデンドロサイトは、UVによる遺伝子損傷に脆弱性が強いことが判明した。また、細胞表面マーカーにより分化段階を検知することが可能であり、オリゴデンドロサイトの分化段階により、UVによるDNA損傷に対する修復能力に差があることも発見した。

Research Products

• [Journal Article] Successful treatment with levothyroxine for idiopathic hypersomnia patients with subclinical hypothyroidism (2009)
  • Author(s): Shinno H, Inami Y, Inagaki T, Kawamukai T, Utani E, Nakamura Y, Horiguchi J
  • Journal Title: General Hospital Psychiatry 31(2) Pages: 190-193
  • Peer Reviewed
• [Journal Article] Successful treatment with levothyroxine for idiopathic hypersomnia patients with subclinical hypothyroidism (2009)
  • Author(s): Shinno H
  • Journal Title: Gen Hosp Psychiatry 31(2) : Pages: 190-193
  • Peer Reviewed
• [Journal Article] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus (2008)
  • Author(s): Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, S Bedi K, Itoh S, Nakamura Y, Takeuchi Y
  • Journal Title: Acta Neurobiol Exp(Wars) 68(4) Pages: 484-93
  • Peer Reviewed
• [Journal Article] J : Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia (2008)
  • Author(s): Shinno H, Inami Y, Inagaki T, Nakamura Y, Horiguchi J
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry 32(3) Pages: 881-885
  • Peer Reviewed
• [Journal Article] Successful treatment with Yi-Gan San for rapid eye movement sleep behavior disorder (2008)
  • Author(s): Shinno H, Kamei M, Inami Y, Horiguchi J, Nakamura Y
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry 32(7) Pages: 1749-1751
  • Peer Reviewed
• [Journal Article] Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia. (2008)
  • Author(s): Shinno H
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 32(3) Pages: 881-885
  • Peer Reviewed
• [Journal Article] Short half-lives of ataxia-associated aprataxin proteins in neuronal cells (2007)
  • Author(s): Hirano M, Asai H, Kiriyama T, Furiya Y, Iwamoto T, Nishiwaki T, Yamamoto A, Mori T, Ueno S
  • Journal Title: Neurosci Lett 419(2) Pages: 184-137
  • Peer Reviewed
• [Journal Article] the SKETCH Study Group, Reliability Study on the Japanese Version of the Clinician's Interview Based Impression of Change (2007)
  • Author(s): Nakamura. Y, Homma A, Kobune S, Tachibana Y, Sato K, Takami I, Nagai S, Sakai M, Fukura K, Matsuda H,Hashimoto H, Kusunoki T
  • Journal Title: (2) Analysis of Subscale Items and -Clinician's Impression-, Dement Geriatr Cogn Disord 23 Pages: 104-115
  • Peer Reviewed
• [Journal Article] Neurons and astrocytes exhibit lower activities of global genome nucleotide excision repair than do fibroblasts (2007)
  • Author(s): Yamamoto A, Nakamura Y, Kobayashi N, Iwamoto T, Yoshioka A, Kuniyasu H, Kishimoto T, Mori T
  • Journal Title: DNA Repair (Amst) 6 Pages: 649-657
  • Peer Reviewed
• [Journal Article] Neurons and astrocytes exhibit lower activities of global genome nucleotide excision repair than do fibroblasts (2007)
  • Author(s): Aya Yamamoto;Yu Nakamura;Nobuhiko Kobayashi;Takaaki Iwamoto;Akira Yoshioka;Hiroki Kuniyasu;Akira Yoshioka;Hiroki Kuniyasu;Toshifumi Kishimoto;Tbshio Mori
  • Journal Title: DNA Repair 6 Pages: 649-657
  • Peer Reviewed
• [Journal Article] Reliability Study on the Japanese Version Impression of Change (2007)
  • Author(s): Yu Nakamura. Akira Homma. Shinichi Kobune. Yosuke Tachibana.
  • Journal Title: Dement Geriatr Cogn Disord 23 Pages: 104-115
  • Peer Reviewed