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Vulnerability of oligodendrocyte to DNA damages-Association with aging and dementia-

Research Project

Project/Area Number 19591358
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKagawa University

Principal Investigator

NAKAMURA Yu  Kagawa University, 医学部, 教授 (70291440)

Co-Investigator(Kenkyū-buntansha) ITO Kouichi  徳島文理大学, 薬学部, 教授 (30291149)
MORI Toshio  奈良県立医科大学, 医学部, 准教授 (10115280)
安藤 延男  香川大学, 医学部附属病院, 助教 (80380161)
二宮 貴至  香川大学, 医学部, 助教 (90363192)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsオリゴデンドロサイト / NER / DNA損傷修復 / 分化 / 脆弱性 / アストロサイト / 神経細胞 / 無血清培地 / アウトロサイト / DNA損傷 / 老化 / 認知症 / 修復
Research Abstract

Neurobasalを主とした無血清培地にて安定にオリゴデンドロサイトを培養が可能であることがわかった。次に、NERによる修復されるDNA損傷特異的な抗体を用いることにより、オリゴデンドロサイトは、UVによる遺伝子損傷に脆弱性が強いことが判明した。また、細胞表面マーカーにより分化段階を検知することが可能であり、オリゴデンドロサイトの分化段階により、UVによるDNA損傷に対する修復能力に差があることも発見した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2009 2008 2007

All Journal Article (11 results) (of which Peer Reviewed: 11 results)

  • [Journal Article] Successful treatment with levothyroxine for idiopathic hypersomnia patients with subclinical hypothyroidism2009

    • Author(s)
      Shinno H, Inami Y, Inagaki T, Kawamukai T, Utani E, Nakamura Y, Horiguchi J
    • Journal Title

      General Hospital Psychiatry 31(2)

      Pages: 190-193

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment with levothyroxine for idiopathic hypersomnia patients with subclinical hypothyroidism2009

    • Author(s)
      Shinno H
    • Journal Title

      Gen Hosp Psychiatry 31(2) :

      Pages: 190-193

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus2008

    • Author(s)
      Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, S Bedi K, Itoh S, Nakamura Y, Takeuchi Y
    • Journal Title

      Acta Neurobiol Exp(Wars) 68(4)

      Pages: 484-93

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] J : Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia2008

    • Author(s)
      Shinno H, Inami Y, Inagaki T, Nakamura Y, Horiguchi J
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry 32(3)

      Pages: 881-885

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment with Yi-Gan San for rapid eye movement sleep behavior disorder2008

    • Author(s)
      Shinno H, Kamei M, Inami Y, Horiguchi J, Nakamura Y
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry 32(7)

      Pages: 1749-1751

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia.2008

    • Author(s)
      Shinno H
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 32(3)

      Pages: 881-885

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short half-lives of ataxia-associated aprataxin proteins in neuronal cells2007

    • Author(s)
      Hirano M, Asai H, Kiriyama T, Furiya Y, Iwamoto T, Nishiwaki T, Yamamoto A, Mori T, Ueno S
    • Journal Title

      Neurosci Lett 419(2)

      Pages: 184-137

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] the SKETCH Study Group, Reliability Study on the Japanese Version of the Clinician's Interview Based Impression of Change2007

    • Author(s)
      Nakamura. Y, Homma A, Kobune S, Tachibana Y, Sato K, Takami I, Nagai S, Sakai M, Fukura K, Matsuda H,Hashimoto H, Kusunoki T
    • Journal Title

      (2) Analysis of Subscale Items and -Clinician's Impression-, Dement Geriatr Cogn Disord 23

      Pages: 104-115

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurons and astrocytes exhibit lower activities of global genome nucleotide excision repair than do fibroblasts2007

    • Author(s)
      Yamamoto A, Nakamura Y, Kobayashi N, Iwamoto T, Yoshioka A, Kuniyasu H, Kishimoto T, Mori T
    • Journal Title

      DNA Repair (Amst) 6

      Pages: 649-657

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurons and astrocytes exhibit lower activities of global genome nucleotide excision repair than do fibroblasts2007

    • Author(s)
      Aya Yamamoto;Yu Nakamura;Nobuhiko Kobayashi;Takaaki Iwamoto;Akira Yoshioka;Hiroki Kuniyasu;Akira Yoshioka;Hiroki Kuniyasu;Toshifumi Kishimoto;Tbshio Mori
    • Journal Title

      DNA Repair 6

      Pages: 649-657

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reliability Study on the Japanese Version Impression of Change2007

    • Author(s)
      Yu Nakamura. Akira Homma. Shinichi Kobune. Yosuke Tachibana.
    • Journal Title

      Dement Geriatr Cogn Disord 23

      Pages: 104-115

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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