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統合失調症の前駆期における発症予防と介入可能性についての検討

Research Project

Project/Area Number 19591377
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionToho University

Principal Investigator

MIZUNO Masafumi  Toho University, 医学部, 教授 (80245589)

Co-Investigator(Kenkyū-buntansha) NEMOTO Takahiro  慶應義塾大学, 医学部精神神経科学教室, 助教 (20296693)
YAMAZAWA Ryoko  慶應義塾大学, 医学部精神神経科学教室, 助教 (70338143)
MORITA Keiko  東邦大学, 医学部精神神経医学講座, 助教 (20449242)
Research Collaborator KOBAYASHI Hiroyuki  (財)精神医学研究所附属東京武蔵野病院, 医師
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords社会精神医学 / 統合失調症 / 予防 / 前駆期 / 臨界期 / ARMS / PRIME / SIPS / SOPS / 発症危険状態
Research Abstract

統合失調症の前駆期における介入により発症予防をするためには、正確な診断方法の確立が求められる。スクリーニング検査と半構造化面接を用い, 発症危険状態(at risk mental state : ARMS)の者を見出し、経過を観察しながら追跡した。ARMSと判断された者は35名で、6ヶ月間経過を追跡できた25名の精神病への移行率は16.0%(4名)、1年間経過を追跡できた17名では17.6%(3名)であった.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (25 results)

All 2009 2008 2007 Other

All Journal Article (11 results) (of which Peer Reviewed: 4 results) Presentation (10 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Clinical practice and research activities for early psychiatric intervention at Japanese centers.2009

    • Author(s)
      Masafumi Mizuno, Michio Suzuki, Kazunori Matsumoto, Masaaki Murakami, Kiyoaki Takeshi, Tetsuo Miyakoshi, Fumiaki Ito, Ryoko Yamazawa, Hiroyuki Kobayashi, Takahiro Nemoto, Masayoshi Kurachi
    • Journal Title

      Early Intervention in Psychiatry 3

      Pages: 5-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神疾患に対する早期介入2008

    • Author(s)
      水野雅文
    • Journal Title

      精神医学 50

      Pages: 217-227

    • Related Report
      2008 Annual Research Report 2008 Final Research Report 2007 Annual Research Report
  • [Journal Article] A self-reported instrument for prodromal symptoms of psychosis : Testing the clinical validity of the PRIME Screen-Revised (PS-R) in a Japanese population.2008

    • Author(s)
      Hiroyuki Kobayashi、Takahiro Nemoto、Hiroki Koshikawa、Yasunori Osono、Ryoko Yamazawa、Masaaki Murakami、Haruo Kashima、Masafumi Mizuno
    • Journal Title

      Schizophrenia Research 106

      Pages: 356-362

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 早期精神病に対する専門外来~ユースクリニック~2008

    • Author(s)
      森田桂子、 武士清昭、 水野雅文
    • Journal Title

      精神科治療学 23

      Pages: 1059-1064

    • Related Report
      2008 Final Research Report
  • [Journal Article] 統合失調症の予防と早期介入2008

    • Author(s)
      森田桂子、水野雅文
    • Journal Title

      精神科臨床サービス 8

      Pages: 170-173

    • Related Report
      2008 Final Research Report
  • [Journal Article] Association between duration of untreated psychosis, preraorbid functioning, and cognitive performance and the outcome of first-episode schizophrenia in Japanese patients : prospective study.2008

    • Author(s)
      Ryoko Yamazawa, Takahiro Nemoto, Hiroyuki Kobayashi, Bun Chino, Haruo Kashima, Masafumi Mizuno
    • Journal Title

      Australian and New Zealand Journal of Psychiatry 42

      Pages: 159-165

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A self-reported instrument for prodromal symptoms of psychosis : Testing the clinical validity of the PRIME Screen-Revised (PS-R) in a Japanese population.2008

    • Author(s)
      Hiroyuki Kobayashi, Takahiro Nemoto, Hiroki Koshikawa, Yasunori Osono, Ryoko Yamazawa, Masaaki Murakami, Haruo Kashima, Masafumi Mizuno
    • Journal Title

      Schizophrenia Research 106

      Pages: 356-362

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 早期精神病に対する専門外来〜ユースクリニック〜2008

    • Author(s)
      森田桂子, 武士清昭, 水野雅文
    • Journal Title

      精神科治療学 23

      Pages: 1059-1064

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 統合失調症の予防と早期介入2008

    • Author(s)
      森田桂子, 水野雅文
    • Journal Title

      精神科臨床サービス 8

      Pages: 170-173

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 早期診断と治療の根拠2007

    • Author(s)
      小林啓之、水野雅文
    • Journal Title

      臨床精神医学 36

      Pages: 377-382

    • NAID

      40016528387

    • Related Report
      2008 Final Research Report
  • [Journal Article] 早期診断と治療の根拠2007

    • Author(s)
      小林啓之, 水野雅文
    • Journal Title

      臨床精神医学 36

      Pages: 377-382

    • NAID

      40016528387

    • Related Report
      2007 Annual Research Report
  • [Presentation] 早期精神病 : ユース世代への早期介入の現状と展望2008

    • Author(s)
      水野雅文
    • Organizer
      平成20年度厚生労働省精神・神経疾患研究委託費精神疾患関連班第18回合同シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-12-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] At risk mental stateに対する早期介入の6ヶ月転帰2008

    • Author(s)
      森田桂子、武士清昭、小林啓之、水野雅文
    • Organizer
      第12回日本精神障害予防研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-14
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 精神病発症危険状態(At Risk Mental State)における主観的体験に対するドーパミンスタビライザー(アリピプラゾール)の効果2008

    • Author(s)
      小林啓之、根本隆洋、山澤涼子、森田桂子、武士清昭、鹿島晴雄、水野雅文
    • Organizer
      第3回日本統合失調症学会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Analysis of clinical ARMS cases in Tokyo2008

    • Author(s)
      K. Morita、H. Kobayashi、R. Yamazawa、K. Takeshi、H. Koshikawa、M. Murakami、 M. Mizuno
    • Organizer
      6th international conference on early psychosis
    • Place of Presentation
      Melbourne
    • Related Report
      2008 Final Research Report
  • [Presentation] Transitions of prepsychotic symptoms during the 'prodromanl' phase2008

    • Author(s)
      Hiroyuki Kobayashi、Ryoko Yamazawa、Keiko Morita、Takahiro Nemoto、Kei Sakuma、Masaaki Murakami、Haruo Kashima、Masafumi Mizuno
    • Organizer
      The 1st International Society of Schizophrnia Congress
    • Place of Presentation
      Venice
    • Related Report
      2008 Final Research Report
  • [Presentation] 前駆状態のアセスメントー症候学的観点からー シンポジウム19統合失調症早期介入の意義と実際2008

    • Author(s)
      小林啓之、山澤涼子、根本隆洋、水野雅文、鹿島晴雄
    • Organizer
      第104回日本精神神経学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Transitions of prepsychotic symptoms during the 'prodromanl'phase.2008

    • Author(s)
      Hiroyuki Kobayashi, Ryoko Yamazawwa, Keiko Morita, Takahiro Nemoto, Kei Sakuma, Masaaki Murakami, Haruo Kashima, Masafumi Mizuno
    • Organizer
      The 1st International Society of Schizophrnia Congress
    • Place of Presentation
      Venice
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of clinical ARMS cases in Tokyo.2008

    • Author(s)
      K. Morita, H. Kobayashi, R. Yamazawa, K. Takeshi, H. Koshikawa, M. Murakami, M. Mizuno
    • Organizer
      6th international conference on early psychosis
    • Place of Presentation
      Melbourne
    • Related Report
      2008 Annual Research Report
  • [Presentation] Early Intervention for Psychosis in Japan : Clinical Activities and Research Findings.2008

    • Author(s)
      M. Mizuno
    • Organizer
      2nd WFSBP Asia-Pacific Congress 2008
    • Place of Presentation
      Toyama
    • Related Report
      2008 Annual Research Report
  • [Presentation] 前駆状態のアセスメント-症候学的観点から-シンポジウム19統合失調症早期介入の意義と実際2008

    • Author(s)
      小林啓之, 山澤涼子, 根本隆洋, 水野雅文, 鹿島晴雄
    • Organizer
      第104回日本精神神経学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Book] 専門医のための精神科臨床リュミエール5中山書店2009

    • Author(s)
      水野雅文
    • Total Pages
      224
    • Publisher
      統合失調症の早期診断と早期介入
    • Related Report
      2008 Final Research Report
  • [Book] 統合失調症の早期診断と早期介入 専門医のための精神科臨床リュミエール52009

    • Author(s)
      水野雅文
    • Total Pages
      224
    • Publisher
      中山書店
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.lab.toho-u.ac.jp/med/omori/mentalhealth/

    • Related Report
      2008 Final Research Report
  • [Remarks] 東邦大学医療センター大森病院イルボスコサイト

    • URL

      http://www.lab.toho-u.ac.jp/med/omori/mentalhealth/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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