| Project/Area Number |
19591379
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
TATENO Amane Nippon Medical School, 医学部, 講師 (50297917)
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| Co-Investigator(Kenkyū-buntansha) |
OKUBO Yoshiro 日本医科大学, 大学院・医学研究科, 教授 (20213663)
SUZUKI Hidenori 日本医科大学, 大学院・医学研究科, 教授 (30221328)
水村 直 日本医科大学, 医学部, 特別研究生 (90287748)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUMURA Sunao 東邦大学, 医学部, 講師 (90287748)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 精神生理学 / うつ病 / MRI / 機能的磁気共鳴撮像法 / 機能変化 / 形態変化 / SPECT |
|---|
| Research Abstract |
We investigated patients with depression using brain morphometry and functional MRI. Patients with depression at the beginning of the treatment showed significantly smaller gray matter volume in anterior cinglate, ventromedial temporal, ventromedial frontal, and caudate head than healthy controls. We made the task for fMRI to evaluate self-esteem and dysfunctional attitude. We evaluate healthy controls and patients with depression who treated with medication and/or cognitive behavioral therapy using fMRI. Our results indicated that regional brain activities of patients with depression changed in the course of the treatment, and the changes varied among treatments.
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