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Systematic genetic study of the ErbB4 signaling in Schizophrenia

Research Project

Project/Area Number 19591387
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

HATTORI Eiji  The Institute of Physical and Chemical Research, 分子精神科学研究チーム, 研究員 (80399443)

Co-Investigator(Kenkyū-buntansha) IWAYAMA Yoshimi  独立行政法人理化学研究所, 分子精神科学研究チーム, リサーチアソシエイト (60399441)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsErbB4シグナリング / 統合失調症 / 髄鞘化 / 双極性障害
Research Abstract

本研究は、ErbB4シグナリング関連遺伝子を中心とした髄鞘化関連遺伝子を解析し、統合失調症との関わりを調べるものである。これら遺伝子につき日本人症例対照サンプル(合計2,120人)の解析を終了し、RTN4、MAG遺伝子座の変異が疾患と関連することを見いだした。また、研究代表者らは同時に日本人集団の全ゲノム解析に従事し、本研究の解析に集団構造の特性による影響が無視できることを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (21 results)

All 2009 2008 2007 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (9 results) Remarks (1 results)

  • [Journal Article] Variable number of tandem repeat polymorphisms of DRD4: re-evaluation of selection hypothesis and analysis of association with schizophrenia2009

    • Author(s)
      Hattori E, Nakajima M, Yamada K, Iwayama Y, Toyota T, Saitou N, Yoshikawa T
    • Journal Title

      Eur J Hum Genet. 17

      Pages: 793-801

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variable number of tandem repeat polymorphisms of DRD4 : re-evaluation of selection hypothesis and analysis of association with schizophrenia2009

    • Author(s)
      Hattori E, et al.
    • Journal Title

      Eur J Hum Genet.

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations2009

    • Author(s)
      Yamada K, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet.

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population2009

    • Author(s)
      Hattori E, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet.

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder2009

    • Author(s)
      Anitha A, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet.

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia2008

    • Author(s)
      Takeshita M, Yamada K, Hattori E, Iwayama Y, Toyota T, Iwata Y, Tsuchiya KJ, Sugihara G, Hashimoto K, Watanabe H, Iyo M, Kikuchi M, Okazaki Y, Yoshikawa T
    • Journal Title

      Schizophr Res. 99

      Pages: 359-64

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and expression analyses reveal elevated expression of syntaxin 1A (STX1A) in high functioning autism2008

    • Author(s)
      Nakamura K, et al.
    • Journal Title

      Int J Neuropsychopharmacol. 11

      Pages: 1073-1084

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analyses of roundabout (ROBO) axon guidance receptors in autism2008

    • Author(s)
      Anitha A, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet 147B

      Pages: 1019-1027

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurotransmission and bipolar disorder : a systematic family-based association study2008

    • Author(s)
      Shi J, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 147B

      Pages: 1270-1277

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm2008

    • Author(s)
      Shi J, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 147B

      Pages: 1047-1055

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population

    • Author(s)
      Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. (in press)

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 2120人の日本人ケースコントロールサンプルにおける統合失調症とNogo関与遺伝子の関連研究2009

    • Author(s)
      治徳大介、服部栄治、岩山佳美、豊田倫子、山田和男、吉川武男
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-24
    • Related Report
      2008 Final Research Report
  • [Presentation] Gene and expression analyses reveal elevated expression of syntaxin 1A in high functioning autism2008

    • Author(s)
      Anitha A, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 双極性障害の遺伝子研究2008

    • Author(s)
      服部栄治
    • Organizer
      シンポジウム「精神神経疾患におけるゲノムワイド解析」 第53回日本人類遺伝学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-09-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 双極性障害の遺伝子研究(シンポジウム)2008

    • Author(s)
      服部栄治
    • Organizer
      日本人類遺伝学会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-09-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetics of Bipolar Disorder2008

    • Author(s)
      Eiji Hattori
    • Organizer
      a symposium of 2nd WFSBP Asia-Pacific Congress and 30th Annual meeting of JSBP
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      2008-09-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Genetics of bipolar disorder (Symposium)2008

    • Author(s)
      Eiji Hattori
    • Organizer
      2^<nd> WFSBP Asia-Pacific Congress and 30^<th> Annual meeting of JSBP
    • Place of Presentation
      富山市
    • Year and Date
      2008-09-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 精神疾患の遺伝学2007

    • Author(s)
      服部栄治
    • Organizer
      第14回慶應臨床遺伝セミナー
    • Place of Presentation
      東京、慶応義塾大学病院新棟11階大会議室
    • Year and Date
      2007-11-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Psychiatric geneticsにおけるヒトゲノム情報の活用2007

    • Author(s)
      服部栄治
    • Organizer
      日本生物学的精神医学会教育セミナー、日本神経精神薬理学会 合同年会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Psychiatric geneticsにおけるヒトゲノム情報の活用2007

    • Author(s)
      服部 栄治
    • Organizer
      日本生物学的精神医学会合同年会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://molpsych.brain.riken.jp/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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