An antidepressant related transcription factor Math2 regulates Prg1 expression and induces neurite differentiation.

• Project/Area Number: 19591390
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: YAMADA Misa National Center of Neurology and Psychiatry, 老人精神保健部, 科研費研究員 (10384182)
• Co-Investigator(Kenkyū-buntansha): YAMADA Mitsuhiko 国立精神・神経センター精神保健研究所, 老人精神保健部, 部長 (60240040) ; TAKAHASHI Kou 国立精神・神経センター精神保健研究所, 老人精神保健部, 外来研究員 (20415582) ; 丸山 良亮 国立精神・神経センター, 精神保健研究所・老人精神保健部, 研究員 (70421831)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 精神薬理学 / 抗うつ薬 / 転写因子 / 大脳皮質初代培養神経細胞 / 網羅的探索

Research Abstract

In the present study, we identified the gene, plasticity-related gene 1 (Prg1), targeted by a transcription factor Math2 which is an antidepressant related gene. Our results may support the hypothesis that Math2-Prg1 mediated plastic changes of nervous system in frontal cortex are involved with therapeutic action of antidepressants.

Research Products

• [Journal Article] Induction of the transcription factor Math2 and its target gene Prg1 after chronic treatment with selective serotonin reuptake inhibitors in rat brain. (2009)
  • Author(s): Yamada, M., Shida, Y., Takahashi, K., Yamada M.
  • Journal Title: J. Mental Health 55 Pages: 103-109
  • Peer Reviewed
• [Journal Article] Induction of the transcription factor Math2 and its target gene Prg1 after chronic treatment with selective serotonin reuptake inhibitors in rat brain (2009)
  • Author(s): Yamada, M., Shida, Y., Takahashi, K., Yamada M.
  • Journal Title: J.Mental Health 55 Pages: 103-109
  • Peer Reviewed
• [Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math2. (2008)
  • Author(s): Yamada, M., Shida, Y., Takahashi, K., Tanioka, T., Nakano, Y., Tobe, T., Yamada, M.
  • Journal Title: J. Neurochem 106 Pages: 2375-2384
  • Peer Reviewed
• [Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math2 (2008)
  • Author(s): Yamada M, Shida Y, Takahashi K, Tanioka T, Nakano Y, Tobe T, Yamada M.
  • Journal Title: J. Neurochem 106 Pages: 2375-2384
  • Peer Reviewed
• [Journal Article] Effects of Methylphenidate on the Hyperemotional Behavior in OlfactoryBulbectomized Mice by Using the Hole-Board Test (2007)
  • Author(s): Kamei J, Hirose N, Oka T, Miy ata S, Saitoh A, Yamada M
  • Journal Title: J Phannacol Sci 103 Pages: 175-180
  • Peer Reviewed
• [Journal Article] TREK-1カリウムチャネル:抗うつ薬創出の新たなターゲット (2007)
  • Author(s): 丸山 良亮, 山田 光彦
  • Journal Title: 日本神経精神薬理学雑誌 27 Pages: 147-151
  • NAID: 10023964462
  • Peer Reviewed
• [Presentation] 抗うつ薬の作用メカニズムに関わる転写因子ADRG701が制御する下流遺伝子の探索 (2007)
  • Author(s): 志田美子, 高橋弘, 山田美佐, 中野泰子, 戸部敞, 山田光彦
  • Organizer: 第30回日本分子生物学会年会, 第80回日本生化学会大会合同大会
  • Place of Presentation: パシフィコ横浜, 神奈川
• [Presentation] 抗うつ薬の作用メカニズムに関わる転写因子が制御する下流遺伝子の探索 (2007)
  • Author(s): 志田 美子, 高橋 弘, 山田 美佐, 中野 泰子, 戸部 敞, 山田 光彦
  • Organizer: 第30回日本分子生物学会年会, 第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: 横浜
• [Presentation] An antidepressant related transcription factor Math2 regulates Prg1 expression and induces neurite differentiation.
  • Author(s): Yamada, M., Yamada, M., Shida, Y., Takahashi, K., Tanioka, T., Nakano, Y, Tobe, T.
  • Organizer: The 1st Meeting of the Asian College of Neuropsychopharmacology
  • Place of Presentation: 京都国際会議場Kyoto, Japan