| Project/Area Number |
19591390
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
YAMADA Misa National Center of Neurology and Psychiatry, 老人精神保健部, 科研費研究員 (10384182)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Mitsuhiko 国立精神・神経センター精神保健研究所, 老人精神保健部, 部長 (60240040)
TAKAHASHI Kou 国立精神・神経センター精神保健研究所, 老人精神保健部, 外来研究員 (20415582)
丸山 良亮 国立精神・神経センター, 精神保健研究所・老人精神保健部, 研究員 (70421831)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 精神薬理学 / 抗うつ薬 / 転写因子 / 大脳皮質初代培養神経細胞 / 網羅的探索 |
|---|
| Research Abstract |
In the present study, we identified the gene, plasticity-related gene 1 (Prg1), targeted by a transcription factor Math2 which is an antidepressant related gene. Our results may support the hypothesis that Math2-Prg1 mediated plastic changes of nervous system in frontal cortex are involved with therapeutic action of antidepressants.
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