Assessment of coronary endothelial function using positron emission tomography

• Project/Area Number: 19591395
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: YOSHINAGA Keiichiro Hokkaido University, 大学院・医学研究科, 特任講師 (30435961)
• Co-Investigator(Kenkyū-buntansha): NISHIJIMA Ken=ichi 北海道大学, 大学院・医学研究科分子イメージング講座, 特任講師 (60364254) ; ZHAO CHOKICHI 北海道大学, 大学院・医学研究科トレーサー情報学講座, 准教授 (80374239)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: PET / 血管内皮機能 / 心筋血流 / 冠危険因子 / 動脈硬化 / ポジトロン断層撮影法

Research Abstract

研究目的はポジトロン断層撮像法(PET)を用い、心筋血流量を定量評価する方法を確立することである。第2の目的はPETによる本計測法を冠血管動脈硬化危険因子保持者のリスク評価へ応用することである。
喫煙者では心筋血流増加率は有意に低下していた。よって心筋血流PETを用いることで早期の冠動脈硬化病変の検出が可能となった。従来までの計測法では非侵襲的に冠動脈の早期の動脈硬化性変化を定量的に評価することが不可能であった。PETを用いた計測法は非侵襲的であり単なるリスク評価にとどまらず治療介入の評価に応用しうる優れた診断法になる可能性がある。

Research Products

• [Journal Article] Repeatability of rest and hyperemic myocardial blood flow measurements with ^<82>Rubidium dynamic PET (2009)
  • Author(s): Manabe O, Yoshinaga K(他5名、2番目)
  • Journal Title: J Nucl Med 50 Pages: 68-71
  • Peer Reviewed
• [Journal Article] Repeatability of rest and hyperemic myocardial blood flow measurements with ^<82>Rubidium dynamic PET (2009)
  • Author(s): Manabe O
  • Journal Title: Journal of Nuclear Medicine 50 Pages: 68-71
  • Peer Reviewed
• [Journal Article] Cardiovascular drug development using radiopharmaceuticals (2009)
  • Author(s): Ukkonen H
  • Journal Title: Current Pharmaceutical Design 15 Pages: 935-942
  • Peer Reviewed
• [Journal Article] No reflow-like pattern in intramyocardial coronary artery suggests myocardial ischemia in patients with hypertrophic cardiomyopathy (2008)
  • Author(s): Kim WS, Yoshinaga K(他8名、5番目)
  • Journal Title: J Cardiol 52 Pages: 7-16
  • NAID: 10024019418
  • Peer Reviewed
• [Journal Article] Cardiovascular drug development using radiopharmaceuticals (2008)
  • Author(s): Ukkonen H, Yoshinaga K(他3名、2番目)
  • Journal Title: Curr Pharmceutical Design 15
  • Peer Reviewed
• [Journal Article] Is ventilatory efficiency (VE/VCO2 slope) associated with right ventricular oxidative metabolism in patients with heart failure ? (2008)
  • Author(s): Ukkonen H, Yoshinaga K(他8名、6番目)
  • Journal Title: Eur J Heart Failure 10(in press) Pages: 1117-22
  • Peer Reviewed
• [Journal Article] Effect of acute and chronic effect of CPAP therapy left ventricular systolic and diastolic function in patients with obstructive sleep apnea and congestive heart failure (2008)
  • Author(s): Johnson CB, Beanlands R, Yoshinaga K(他4名、3番目)
  • Journal Title: Can J Cardiol 24 Pages: 697-704
  • Peer Reviewed
• [Journal Article] Heterogenous reduction of myocardial oxidative metabolism in patients with ischemic and dilated cardiomyopathy using C-11 acetate PET (2008)
  • Author(s): Wu JW, Yoshinaga K, (他7名、6番目)
  • Journal Title: Circ J 72 Pages: 786-92
  • NAID: 110006680559
• [Journal Article] No reflow-like pattern in intramyocardial coronary artery suggests myocardial ischemia in patients with hypertrophic cardiomyopathy (2008)
  • Author(s): Kim WS
  • Journal Title: Journal of Cardiology 52 Pages: 7-16
  • Peer Reviewed
• [Journal Article] The effects of continuous positive airway pressure on myocardial energetics in patients with heart failure and obstructive sleep apnea (2007)
  • Author(s): Yoshinaga K, Beanlanlds R (他7名、1番目)
  • Journal Title: J Am Coll Cardiol 49 Pages: 450-8
  • Peer Reviewed
• [Journal Article] Quantification of Myocardial Blood Flow With 82Rb Dynamic PET Imaging (2007)
  • Author(s): Lortie M, Yoshinaga K (他3名、3番目)
  • Journal Title: Eur J Nucl Med Mol Imaging 34 Pages: 1765-74
  • Peer Reviewed
• [Journal Article] CCS/CAR/CANM/CNCS/Can SCMR Joint position statement on advanced non-invasive cardiac imaging using positron emission tomography, magnetic resonance imaging and multi-detector computed tomographic angiography in the diagnosis and evaluation of ischemic heart disease (2007)
  • Author(s): Beanlands RSB, Yoshinaga K(他16名、15番目)
  • Journal Title: Can J Cardiol 23 Pages: 107-19
  • Peer Reviewed
• [Journal Article] Imaging myocardial metabolism (2007)
  • Author(s): Yoshinaga K, Tamaki N
  • Journal Title: Curr Opin Biotechnol 18 Pages: 52-9
• [Journal Article] Will 3-dimentional PET-CT enable the routine quantification of myocardial blood flow? (2007)
  • Author(s): deKemp RA, Yoshinaga K, and Beanlands R.
  • Journal Title: J Nucl Cardiol 14 Pages: 380-97
• [Journal Article] Will 3-dimentional PET-CT enable the routine quantification of myocardial blood flow? (2007)
  • Author(s): deKemp RA, Yoshinaga K, Beanlands R.
  • Journal Title: Journal of Nuclear Cardiology 14 Pages: 380-397
  • Peer Reviewed
• [Journal Article] Quantification of Myocardial Blood Flow With 82Rb Dynamic PET Imaging. (2007)
  • Author(s): Lortie M, Beanlands RSB, Yoshinaga K, Klein R, deKemp R.
  • Journal Title: Eur J Nucl Med Mol Imaging 34 Pages: 1765-1774
  • Peer Reviewed
• [Journal Article] CCS/CAR/CANM/CNCS/CanSCMR Joint position statement on advanced non-invasive cardiac imaging using positron emission tomography, magnetic resonance imaging and multi-detector computed tomographic angiography in the diagnosis and evaluation of ischemic heart disease. (2007)
  • Author(s): Beanlands RSB, Chow BJW, Dick A, Friedrich MG, Gule nchyn KY, Kiess M, Leong-Poi H, Miller RM, Nichol G, Freeman M, Bogaty P, Honos G, Hudon G, Wisenberg G, Van Berkom J, Williams K, Yoshinaga K, Graham J.
  • Journal Title: Can J Cardiol 23 Pages: 107-119
  • Peer Reviewed
• [Journal Article] Comparison of 99m Tc-annexinA5 with 18F-FDG for the detection of atherosclerosis in Apo E-/- mice. (2007)
  • Author(s): Zhao Y, Kuge Y, Morita K, Inubushi M, Zhao S, Strauss HW, Blankenberg FG, Tamaki N.
  • Journal Title: Eur J Nucl Med Mol Imaging 34 Pages: 1747-1755
  • Peer Reviewed
• [Presentation] Development of Coronary Endothelial Function Measurements with Rubidium-82 PET-Comparison with Oxygen 15-Labeled Water PET (2009)
  • Author(s): Yoshinaga K
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Effect of smoking cessation on coronary endothelial dysfunction in young and middle-aged healthy smokers (2009)
  • Author(s): Naya M
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Development of Coronary Endothelial Function Measurements with Rubidium-82 PET-Comparison with Oxygen 15-Labeled Water PET- (2009)
  • Author(s): Yoshinaga K
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪大阪国際会議場
• [Presentation] Effect of smoking cessation on coronary endothelial dysfunction in young and middle-aged healthy smokers (2009)
  • Author(s): Naya M
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪大阪国際会議場
• [Presentation] ルビジウムPETを用いた心筋血流量値の再現性 (2008)
  • Author(s): 真鍋治
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 千葉幕張メッセ
  • Year and Date: 2008-10-26
• [Presentation] Measurement of Coronary Endothelial Function with Rubidium-82 PET-Comparison with Oxygen 15-Labeled Water PET (2008)
  • Author(s): Yoshinaga K
  • Organizer: -^<55th> Society of Nuclear Medicine Annual Meeting
  • Place of Presentation: New Orleans, LA
• [Presentation] Repeatability of rest and hyperemic myocardial blood flow measurements with ^<82>Rubidium dynamic PET (2008)
  • Author(s): Manabe O
  • Organizer: 55^<th> Society of Nuclear Medicine Annual Meeting
  • Place of Presentation: New Orleans, LA
• [Presentation] New Quantification Algorithm of Regional Myocardial Blood Flow with 82 Rubidium PET (2008)
  • Author(s): Katoh C
  • Organizer: 55^<th> Society of Nuclear Medicine Annual Meeting
  • Place of Presentation: New Orleans
• [Presentation] ルビジウムPETを用いた心筋血流量値の再現性 (2008)
  • Author(s): 真鍋治
  • Organizer: 第48回日本核医学会学術集会
  • Place of Presentation: 幕張
• [Presentation] ルビジウム82心筋PETにおける局所心筋血流量定量測定の安定化アルゴリズムの開発 (2008)
  • Author(s): 加藤千恵次
  • Organizer: 第48回日本核医学会学術集会
  • Place of Presentation: 幕張
• [Presentation] 中間報告1心筋SPECT標準(JSNM2007)の作成と臨床的検証 (2008)
  • Author(s): 中嶋憲一
  • Organizer: 第48回日本核医学会学術集会
  • Place of Presentation: 幕張
• [Presentation] ジェネレータ産生82Rubidiumを用いた新たな心筋血流PETによる定量的局所心筋血流計測の有用性 (2008)
  • Author(s): 吉永恵一郎
  • Organizer: 第56回日本心臓病学会学術集会
  • Place of Presentation: 東京
• [Presentation] ジェネレータ産生82-Rubidium PETによる新たな心筋血流イメージングの診断能および画像特性 (2008)
  • Author(s): 真鍋治
  • Organizer: 第67回日本医学放射線学会総会学術集会
  • Place of Presentation: 横浜
• [Presentation] ルビジウム82心筋PETにおける局所心筋血流定量法の開発 (2008)
  • Author(s): 加藤千恵次
  • Organizer: 第67回日本医学放射線学会総会学術集会
  • Place of Presentation: 横浜
• [Presentation] Measurement of Coronary Endothelial Function with Rubidium-82 PET - Comparison with Oxygen 15-Labeled Water PET (2008)
  • Author(s): Yoshinaga K
  • Organizer: 72^<nd> Japanese Circulation Society Annual Meeting
  • Place of Presentation: Fukuoka
• [Presentation] ジェネレータ産生^<82>Rubidium PETによる新たな心筋血流イメージング (2008)
  • Author(s): 吉永恵一郎
  • Organizer: 第18回日本心血管画像動態学会
  • Place of Presentation: 津
• [Presentation] Measurement of Coronary Endothelial Function with Rubidium-82 PET-Comparison with Oxynen 15-Labeled Water PET- (2008)
  • Author(s): Yoshinaga K
  • Organizer: 55^<th> Society of Nuclear Medicine Annual Mee tina
  • Place of Presentation: New Orleans, LA Exhibit Hall
• [Presentation] Repeatability of rest and hyperemic myocardial blood flow measurements with 82Rubidium dynamic PET (2008)
  • Author(s): Manabe O
  • Organizer: 55^<th> Society of Nuclear Medicine Annual Mee ting
  • Place of Presentation: New Orleans, LA Exhibit Hall
• [Presentation] New Quantification Algorithm of Regional Myocardial Blood Flow with 82Rubidium PET (2008)
  • Author(s): Katoh C
  • Organizer: 55^<th> Society of Nuclear Medicine Annual Mee ting
  • Place of Presentation: New Orleans, LA Exhibit Hall
• [Presentation] ジェネレータ産生82-Rubidium PETによる新たな心筋血流イメージングの診断能および画像特性 (2008)
  • Author(s): 真鍋治
  • Organizer: 第67回日本医学放射線学会総会学術集会
  • Place of Presentation: 横浜パシフィコ横浜
• [Presentation] ルビジウム82心筋PETにおける局所心筋血流定量法の開発 (2008)
  • Author(s): 加藤千恵次
  • Organizer: 第67回日本医学放射線学会総会学術集会
  • Place of Presentation: 横浜パシフィコ横浜
• [Presentation] ジェネレータ産生82Rubidiumを用いた新たな心筋血流PETによる定量的局所心筋血流計測の有用性 (2008)
  • Author(s): 吉永恵一郎
  • Organizer: 第56回日本心臓病学会学術集会
  • Place of Presentation: 東京東京国際フォーラム
• [Presentation] Effects of amlodipine and atenolol on myocardial perfusion assessed by PET imaging. (2007)
  • Author(s): Yoshinaga K, Beanlands R, deKemp R, Morin J, Aung M, Farncombe T, Gulenchyn KY, Nahmias C, Mckelvie R, Davies RF
  • Organizer: 第55回日本心臓病学会学術集会
  • Place of Presentation: 浦安、千葉シェラトン・グランデ・トーキョーベイ・ホテル
  • Year and Date: 2007-09-11
• [Presentation] FDG PET imaging in the PRKAG2 cardiac syndrome demonstrates altered myocardial glucose uptake (2007)
  • Author(s): Ha AC
  • Organizer: 79^<th> Annuai Meeting of American Heart Association
  • Place of Presentation: Orlando, Florida
• [Presentation] 11C-CGP-12177 PETで測定した心筋β受容体密度の低下と心不全の重症度との関連 (2007)
  • Author(s): 納谷昌直
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台
• [Presentation] Effects of amlodipine and atenolol on myocardial perfusion assessed by PET imaging (2007)
  • Author(s): Yoshinaga K
  • Organizer: 第55回日本心臓病学会学術総会
  • Place of Presentation: 千葉
• [Book] Philadelphia, PA Chapter11 (2009)
  • Author(s): Yoshinaga K, Tamaki N, Ruddy TD
  • Publisher: In Principles and practice of PET and PET/CT, 2^<nd> edition. Wahl RL,
• [Book] Evaluation of Myocardial perfusion. In Principles and practice of PET and PET/CT, 2^<nd> edition (2009)
  • Author(s): Yoshinaga K
  • Publisher: Lippincott Williams and Wilkins
• [Book] 新目で見る循環器シリーズ11 ; 狭心症、PET検査 (2009)
  • Author(s): 吉永恵一郎
  • Publisher: Medical View
• [Book] PET検査, 狭心症, 新目でみる循環器シリーズ11(鶴見由起夫,住吉徹也(編集)) (2008)
  • Author(s): 吉永恵一郎,玉木長良
  • Publisher: MEDICAL VIEW
• [Book] 核医学で迫る. 新・心臓病診療プラクティス(伊藤 浩, 吉川純一(編集)) (2008)
  • Author(s): 玉木長良,吉永恵一郎
  • Publisher: 文光堂
• [Book] 核医学, PET. 心筋症(松崎益徳(編集)) (2008)
  • Author(s): 吉永恵一郎,玉木長
  • Publisher: 最新医学社
• [Book] Salt Lake City UT (2007)
  • Author(s): Yoshinaga K, Beanlands R, Heston T. Myocardial ischemia
  • Publisher: In Diagnostic Imaging
• [Book] AMIRSYS : Salt Lake City UT (2007)
  • Author(s): Yoshinaga K, Beanlands R, Heston T. Myocardial infarction
  • Publisher: In Diagnostic Imaging
• [Book] Salt Lake City UT (2007)
  • Author(s): Yoshinaga K, Beanlands R, Heston T. Myocardial viability
  • Publisher: In Diagnostic Imaging
• [Book] PET検査. 目でみる循環器病シリーズ11 : 狭心症(鶴見由紀夫、住吉徹哉編集) (2007)
  • Author(s): 吉永恵一郎, 玉木長良
  • Publisher: MEDICAL VIEW
• [Book] 心筋虚血/再還流障害リスクとviability評価 PET検査. 目でみる循環器病シリーズ10(吉野秀朗編集) (2007)
  • Author(s): 玉木長良、吉永恵一郎
  • Publisher: MEDICAL VIEW