Creation and common use of Japanese standard databases for myocardial perfusion and function

• Project/Area Number: 19591403
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: NAKAJIMA Kenichi Kanazawa University, 医学系, 准教授 (00167545)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 心機能 / 心臓核医学 / データベース / 標準 / 多施設研究

Research Abstract

核医学的心筋イメージングは,心筋の血流,代謝,心機能,交感神経に関連した生理学的イメージングとして,循環器疾患の診断に利用されているが,日本人の標準データベースは構築されていなかった。そこで,国内の多施設研究により正常データベースを構築し,その特徴を解析した。また,その診断精度に関しても,多施設研究により検討を加え,コンピュータによる定量処理結果が診断上妥当であることを確認した。心筋脂肪酸代謝,交感神経イメージング,心機能のデータベースも作成した。これらの標準化データベースは定量の基礎となり臨床応用が期待できる。

Research Products

• [Journal Article] Normal values for nuclear cardiology: Japanese databases for myocardial perfusion, fatty acid and sympathetic imaging and left ventricular function. (2010)
  • Author(s): Nakajima K.
  • Journal Title: Ann Nucl Med 24(Invited review) Pages: 125-135
  • NAID: 10026390699
• [Journal Article] Normal values for nuclear cardiology : Japanese databases for myocardial perfusion, fatty acid and sympathetic imaging and left ventricular function (2010)
  • Author(s): Nakajima K
  • Journal Title: Ann Nucl Med 24(印刷中)
  • NAID: 10026390699
• [Journal Article] Standardization of the heart-to-mediastinum ratio of iodine-123-labeled-meta-iodobenzylguani dine uptake using dual energy window method: Feasibility of correction from different camera-collimator combinations. (2009)
  • Author(s): Matsuo S, Nakajima K, Okuda K, Kawano M, Ishikawa T, Hosoya T, Taki J, Kinuya S.
  • Journal Title: Eur J Nucl Med Mol Imaging 36 Pages: 560-566
  • Peer Reviewed
• [Journal Article] Attenuation correction of myocardial SPECT by scatter-photopeak window method in normal subjects. (2009)
  • Author(s): Okuda K, Nakajima K, Motomura N, Kubota M, Yamaki N, Maeda H, Matsuo S, Kinuya S.
  • Journal Title: Ann Nucl Med 23 Pages: 501-506
  • NAID: 10025136854
  • Peer Reviewed
• [Journal Article] Characterization of Japanese standards for myocardial sympathetic and metabolic imaging in comparison with perfusion imaging. (2009)
  • Author(s): Matsuo S, Nakajima K, Yamashina S, Sakata K, Momose M, Hashimoto J, Kumita S, Kawano M, Okuda K.
  • Journal Title: Ann Nucl Med 23 Pages: 517-522
  • NAID: 10026390175
  • Peer Reviewed
• [Journal Article] The importance of population-specific normal database for quantification of myocardial ischemia: Comparison between Japanese 360 and 180-degree databases and a US database. (2009)
  • Author(s): Nakajima K, Okuda K, Kawano M, Matsuo S, Slomka P, Germano G, Kinuya S
  • Journal Title: J Nucl Cardiol 16 Pages: 422-430
  • Peer Reviewed
• [Journal Article] Characterization of Japanese standards for myocardial sympathetic and metabolic imaging in comparison with perfusion imaging (2009)
  • Author(s): Matsuo S, Nakajima K, et al
  • Journal Title: Ann Nucl Med 23 Pages: 517-522
  • NAID: 10026390175
  • Peer Reviewed
• [Journal Article] The importance of population-specific normal database for quantification of myocardial ischemia : Comparison between Japanese 360 and 180-degree databases and a US database (2009)
  • Author(s): Nakajima K, Okuda K, et al
  • Journal Title: J Nucl Cardiol 16 Pages: 422-430
  • Peer Reviewed
• [Journal Article] Standardization of the heart-to-mediastinum ratio of iodine-123-labeled-meta-iodobenzylguanidine uptake using dual energy window method : Feasibility of correction from different camera-collimator combinations (2009)
  • Author(s): Matsuo S, Nakajima K, et al
  • Journal Title: Eur J Nucl Med 36 Pages: 560-566
  • Peer Reviewed
• [Journal Article] Attenuation correction of myocardial SPECT by scatter-photopeak window method in normal subjects (2009)
  • Author(s): Okuda K, Nakajima K, et al
  • Journal Title: Ann Nucl Med 23 Pages: 501-506
  • NAID: 10025136854
  • Peer Reviewed
• [Journal Article] The importance of population specific normal database for quantification of myocardial ischemia : Comparison between Japanese 360 and 180-degree databases and a US database (2009)
  • Author(s): Nakajima K, Okuda K, Kawano M, Matsuo S, Slomka P, Germano G, Kinuya S
  • Journal Title: J Nucl Cardiol 16(印刷中)
  • Peer Reviewed
• [Journal Article] Standardization of the heart-to-mediastinum ratio of iodine-123-labeled-meta-lodobenzylguanidine uptake using dual energy window method : Feasibility of correction from different camera-collimator combinations (2009)
  • Author(s): Matsuo S, Nakajima K, Okuda K, Kawano M, Ishikawa T. Hosoya T, Taki J, Kiniiya S
  • Journal Title: Eur J Nucl Med Mol Imaging 36(印刷中)
  • Peer Reviewed
• [Journal Article] Regional wall thickening in gated myocardial perfusion SPECT in a Japanese population: Effect of sex, radiotracer, rotation angles and frame rates. (2008)
  • Author(s): Akhter N, Nakajima K, Okuda K, Matsuo S, Yoneyama T, Taki J, Kinuya S.
  • Journal Title: Eur J Nucl Med Mol Imaging 35 Pages: 1608-1615
  • NAID: 120001130402
  • Peer Reviewed
• [Journal Article] Regional wall thickening in gated myocardial perfusion SPECT In a Japanese population : Effect of sex, radiotracer, rotation angles and frame rates. (2008)
  • Author(s): Akhter N, Nakajima K, Okuda K, Matsuo S, Yoneyama T, Taki J, Kinuya S
  • Journal Title: Eur J Nucl Med Mol Imaging 35 Pages: 1608-15
  • NAID: 120001130402
  • Peer Reviewed
• [Journal Article] Regional wall thickening in gated myocardial perfusion SPECT in a Japanese population:Effect of sex, radiotracer, rotation angles and frame rates (2008)
  • Author(s): Akhter N, Nakajma K, Okuda K, et. al.
  • Journal Title: Eur J Nucl Med Mol Imaging 35(webでの先行公開)
  • Peer Reviewed
• [Journal Article] Creation and characterization of Japanese standards for myocardial perfusion SPECT: Database from Japanese Society of Nuclear Medicine Working Group. (2007)
  • Author(s): Nakajima K, Kumita S, Ishida Y, Momose M, Hashimoto J, Morita K, Taki J, Yamashina S, Maruno H, Ogawa M, Kubota M, Takahashi M, Odagawa T, Yokozuka K.
  • Journal Title: Ann Nucl Med 21 Pages: 505-511
  • NAID: 10020001066
  • Peer Reviewed
• [Journal Article] Correction of I-123-labeled meta-iodobenzylguanidine uptake with multi-window methods for standardization of the heart to mediastinum ratio. (2007)
  • Author(s): Nakajima K, Matsubara K, Ishikawa T, Motomura N, Maeda R, Akhter N, Okuda K, Taki J, Kinuya S.
  • Journal Title: J Nucl Cardiol 14 Pages: 843-851
  • Peer Reviewed
• [Journal Article] Creation and characterization of Japanese standards fo rmyocardial perfusion SPECT:Database from Japanese Society of Nuclear Medicine working group (2007)
  • Author(s): Nakajima K, Kumita S, Ishida Y, et. al.
  • Journal Title: Ann Nucl Med 21 Pages: 505-511
  • Peer Reviewed
• [Journal Article] Correction of iodine-123-labeled meta-iodobenzylguanidine uptake withmulti-window methods for standardization of the heart-to-mediastinum ratio (2007)
  • Author(s): Nakajima K, Matsubara K, Ishikawa T, et. al.
  • Journal Title: J Nucl Cardiol 14 Pages: 843-51
  • NAID: 120000806372
  • Peer Reviewed
• [Presentation] 123I-MIBGにおけるH/M比の補正:2つのコリメータ特性補正法の比較. (2009)
  • Author(s): 奥田光一, 中嶋憲一, 松尾信郎, 細谷徹夫, 石川丈洋, 流俊介, 若林大志, 滝淳一, 絹谷清剛
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川市文化会館(北海道)
  • Year and Date: 2009-10-02
• [Presentation] 心筋SPECT(JSNM2007)の作成と臨床的検証. (2009)
  • Author(s): 中嶋憲一
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川市文化会館(北海道)
  • Year and Date: 2009-10-01
• [Presentation] for JSNM-working group. Characteristics of normal myocardial SPECT database created by Japanese multiple nuclear medicine centers. (2009)
  • Author(s): Nakajima K, Matsuo S, Okuda K, Kumita S, Ishida Y, Momose M, Yamashina S
  • Organizer: The 9th International Conference of Nuclear Cardiology
  • Place of Presentation: Palau de Congressos de Barcelona(Spain)
  • Year and Date: 2009-05-11
• [Presentation] Standardization of the heart-to-mediastinum ratio of iodine-123-labeled-meta-iodobenzylguani dine uptake using dual energy window method. (2009)
  • Author(s): Matsuo S, Nakajima K, Okuda K, Kawano M, Ishikawa T, Hosoya T, Taki J, Kinuya S.
  • Organizer: The 9th International Conference of Nuclear Cardiology
  • Place of Presentation: Palau de Congressos de Barcelona (Spain)
  • Year and Date: 2009-05-11
• [Presentation] Characteristics of normal myocardial SPECT database created by Japanese multiple nuclear medicine centers (2009)
  • Author(s): Nakajima K, Matsuo S, et al
  • Organizer: The 9th International Conference of Nuclear Cardiology(第9回国際心臓核医学会議)
  • Place of Presentation: (会場名)Palau de Congressosde Barcelona(開催都市)バルセロナ、スペイン
• [Presentation] Importance of population-specific normal database for quantification of myocardial ischemia: Comparison between Japanese 360°/180° and US databases. (2008)
  • Author(s): Nakajima K, Okuda K, Kawano M, Slomka P, Akhter N, Matsuo S, Taki J, Germano G.
  • Organizer: The 55th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: Ernest Morial Convention Center(USA)
  • Year and Date: 2008-06-16
• [Presentation] Effect of attenuation correction on normal myocardial perfusion SPECT database using SSPAC method. (2008)
  • Author(s): Okuda K, Nakajima K, Motomura N, Kubota M, Yamaki N, Maeda H, Taki J, Kinuya S.
  • Organizer: Annual Meeting of the Society of Nuclear Medicine, The 55th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: Ernest Morial Convention Center(USA)
  • Year and Date: 2008-06-16
• [Presentation] ワーキンググループ中間報告「心筋SPECT標準 (JSNM2007)の作成と臨床的検証) (2008)
  • Author(s): 中嶋憲一
  • Organizer: 日本核医学会学術総会
  • Place of Presentation: 千葉市幕張メッセ
• [Presentation] 123I-MIBG定量解析のためのH/M比自動算出ソフトウェア (2008)
  • Author(s): 奥田光一, 中嶋憲一, 松尾信郎, 細谷徹夫, 石川丈洋, 松原孝祐, 何野匡哉, 瀧淳一, 絹谷清剛
  • Organizer: 日本核医学会学術総会
  • Place of Presentation: 千葉市幕張メッセ
• [Presentation] 日米の標準データベースの違いが心筋SPECTの定量値に与える影響 (2008)
  • Author(s): 中嶋憲一, 松尾信郎, 奥田光一, 河野匡哉, Akhter Nasima, 滝淳一, 絹谷清剛, Slomka Piotr, Germano Guido
  • Organizer: 日本核医学会学術総会
  • Place of Presentation: 千葉市幕張メッセ
• [Presentation] SSPAC法により減弱補正された心筋正常データベースの特徴 (2008)
  • Author(s): 奥田光一, 中嶋憲一, 松尾信郎, 本村信篤, 久保田雅博, 山木範泰, 前田壽登, 瀧淳一, 絹谷清剛
  • Organizer: 日本核医学会学術総会
  • Place of Presentation: 千葉市幕張メッセ
• [Presentation] Importance of population-specific normal database for quantification of myocardial ischemia : Comparison between Japanese 360°/180°and US databases (2008)
  • Author(s): Nakajima K, Kuda K, Kawano M, Slomka P, Akhter N, Matsuo S. Taki J, Germano G
  • Organizer: Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: New Orleans, 米国
• [Presentation] Regional wall thickening in gated myocardial perfusion SPECT: effect of gender, radiotracer and frame rates. (2007)
  • Author(s): Akhter N, Nakajima K, Okuda K, Yoneyama T, Taki J, Michigishi T, Kinuya S.
  • Organizer: The 47th Annual Meeting of the Japanese Society of Nuclear Medicine
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2007-11-04
• [Presentation] MIBG取込の標準化に関する提案:2エネルギーウィンドウ法と自動処理ソフトウェアの検討。 (2007)
  • Author(s): 中嶋憲一, 松原孝祐, Akhter Nasima, 奥田光一, 米山達也, 滝淳一, 絹谷清剛, 石川丈洋, 細谷徹夫, 寺岡悟見, 本村信篤
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2007-11-04
• [Presentation] I-123 MIBG定量における2および3エネルギーウィンドウ法の補正効果ー心縦画比校正用ファントムによる検討. (2007)
  • Author(s): 松原孝祐, 中嶋憲一, 本村信篤, 石川丈洋, 前田遼, Akhter Nasima, 奥田光一, 山田正人, 絹谷清剛
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2007-11-04
• [Presentation] 日本人における心筋SPECTデータの標準化. (2007)
  • Author(s): 中嶋憲一
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2007-11-04
• [Presentation] 寺岡悟見.心筋SPECTにおける血流欠損の定量的スコアリング方法. (2007)
  • Author(s): 奥田光一, 中嶋憲一, 米山達也, 瀧淳一, 絹谷清剛, 細谷徹夫, 石川丈洋
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2007-11-04
• [Presentation] MIBG取込の標準化に関する提案:2エネルギーウィンドウ法と自動処理ソフトウェアの検討 (2007)
  • Author(s): 中嶋 憲一、松原 孝祐, 他
  • Organizer: 日本核医学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-04
• [Presentation] I-123MIBG定量における2および3エネルギーウィンドウ法の補正効果-心縦画比校正用ファントムによる検討 (2007)
  • Author(s): 松原 孝祐、中嶋 憲一, 他
  • Organizer: 日本核医学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-04
• [Presentation] Regional wall thickening in gated myocardial perfusion SPECT:effect of gender, radiotracer and frame rates (2007)
  • Author(s): Akther N, Nakajima K, 他
  • Organizer: Annual Meeting of the apanese Society of Nuclear Medicine
  • Place of Presentation: Sendai
  • Year and Date: 2007-11-04
• [Presentation] 心筋SPECTにおける血流欠損の定量的ス耳アリング方法 (2007)
  • Author(s): 奥田 光一、中嶋 憲一, 他
  • Organizer: 日本核医学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-04
• [Presentation] Gated SPECTにおける壁運動と壁厚肥厚率:正常な心機能患者による標準の作 (2007)
  • Author(s): 奥田 光一、中嶋 憲一, 他
  • Organizer: 日本核医学会中部地方会
  • Place of Presentation: 金沢
  • Year and Date: 2007-06-30
• [Presentation] Gated SPECTにおける壁運動と壁厚肥厚率の標準値 (2007)
  • Author(s): 奥田光一, 中嶋憲一, Akhter Nasima, 萱野大樹, 福岡誠, 米山達也, 瀧淳一, 絹谷清剛
  • Organizer: 日本心臓核医学会学術大会
  • Place of Presentation: 東京カンファレンスセンター(東京都)
  • Year and Date: 2007-06-16
• [Presentation] Gated SPECTにおける壁運動と壁厚肥厚率の標準値 (2007)
  • Author(s): 奥田 光一、中嶋 憲一, 他
  • Organizer: 日本心臓核医学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-16