Evaluation of brain and whole-body micro-dosing pharmacokinetics of <11>^C-labeled donepezil in rats by means of planar positron imaging system

• Project/Area Number: 19591416
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: SHIMOSEGAWA Eku Osaka University, 医学系研究科, 准教授 (30370258)
• Co-Investigator(Kenkyū-buntansha): HATAZAWA Jun 大阪大学, 医学系研究科, 教授 (70198745) ; INOUE Osamu 大阪大学, 医学系研究科, 教授 (50159969) ; MURASE Kenya 大阪大学, 医学系研究科, 教授 (50157773)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 薬物動態 / ポジトロン / マイクロドージング / 脳

Research Abstract

対向型ポジトロンイメージング装置と陽電子放出核種標識放射性トレーサを用いて、医薬品の体内動態を解析する手法を確立することを目的として、認知症治療薬である医薬品(<11>^C-donepezil)の標識合成技術の開発およびマイクロドージング(100μg以下)における静脈投与時の動態解析を行う。

Research Products

• [Journal Article] Chronic middle cerebral artery occlusion : a hemodynamic and metabolic study with positron-emission tomography (2008)
  • Author(s): Tanaka M, Shimosegawa E, Kajimoto K, Kimura Y, Kato H, Oku N, Hori M, Kitagawa K, Hatazawa J
  • Journal Title: AJNR Am J Neuroradiol 29 Pages: 1841-1846
  • Peer Reviewed
• [Journal Article] Evaluation of brain and whole-body pharmacokinetics of <11>^C-labeled diphenylhydantoin in rats by means of planar positron imaging system (2008)
  • Author(s): Hasegawa Y, Kanai Y, Hasegawa S, Okamoto T, Matsui T, Shimosegawa E, Kurachi Y, Hatazawa J
  • Journal Title: Ann Nucl Med 22 Pages: 301-307
  • NAID: 10021281082
  • Peer Reviewed
• [Journal Article] Cerebral hemodynamics and oxygen metabolism in patients with moyamoya syndrome associated with atherosclerotic steno-occlusive arterial lesions (2008)
  • Author(s): Kato H, Shimosegawa E, Oku N, Kimura Y, Kajimoto K, Tanaka M, Hori M, Kitagawa K, Hatazawa J
  • Journal Title: Cerebrovasc Dis 26 Pages: 9-15
  • Peer Reviewed
• [Journal Article] MRI-based correction for partial-volume effect improves detectability of intractable epileptogenic foci on 123I-iomazenil brain SPECT images (2008)
  • Author(s): Kato H, Shimosegawa E, Oku N, Kitagawa K, Kishima H, Saitoh Y, Kato A, Yoshimine T, Hatazawa J
  • Journal Title: J Nucl Med 49 Pages: 383-289
  • Peer Reviewed
• [Journal Article] Effect of PK11195 on attenuating the enhancement of glucose utilization induced by quinolinic acid infusion in the rat brain (2008)
  • Author(s): Amitani M, Ohashi A, Hatazawa J, Gee A, Inoue O
  • Journal Title: Synapse 62 Pages: 253-258
  • Peer Reviewed
• [Journal Article] 18F-FDG-PET in patients with malignant lymphoma having long-term follow-up : staging and restaging, and evaluation of treatment response and recurrence. (2008)
  • Author(s): Isohashi K, et al.
  • Journal Title: Ann Nucl Med 22 Pages: 795-802
  • Peer Reviewed
• [Journal Article] (18)F-FDG accumulation in the oral cavity is associated with periodontal disease and apical periodontitis : aninitial demonstration on PET/CT. (2008)
  • Author(s): Shimamoto H, et al.
  • Journal Title: Ann Nucl Med 22 Pages: 587-593
  • Peer Reviewed
• [Journal Article] Chronic middle cerebral artery occlusion : a hemodynamic and metabolic study with positron-emission tomography. (2008)
  • Author(s): Tanaka M, et al.
  • Journal Title: AJNR Am J Neuroradiol 29 Pages: 1841-1846
  • Peer Reviewed
• [Journal Article] Evaluation of brain and whole-body pharmacokinetics of 11C-labeled diphenylhydantoin in rats by means of planar positron imaging system. (2008)
  • Author(s): Hasegawa Y, et al.
  • Journal Title: Ann Nucl Med 22 Pages: 301-307
  • Peer Reviewed
• [Journal Article] Cerebral hemodynamics and oxygen metabolism in patients with moyamoya syndrome associated with atherosclerotic steno-occlusive arterial lesions. (2008)
  • Author(s): Kato H, et al.
  • Journal Title: Cerebrovasc Dis 26 Pages: 9-15
  • Peer Reviewed
• [Journal Article] MRI-based correction for partial-volume effect improves detect ability of intractable epileptogenic foci on 123I-iomazenil brain SPECT images. (2008)
  • Author(s): Ka to H, et al.
  • Journal Title: J Nucl Med 49 Pages: 383-389
  • Peer Reviewed
• [Journal Article] Effect of PK11195 on attenuating the enhancement of glucose utilization induced by quinolinic acid infusion in the rat brain. (2008)
  • Author(s): Amitani M, et al.
  • Journal Title: Synapse 62 Pages: 253-258
  • Peer Reviewed
• [Journal Article] Evaluation of Brain and Whole-body Pharmacokinetics of^<11>C-labeled Diphenyl-hydantoin in Rats by Means of Planar Positron Imaging System (2008)
  • Author(s): Hasegawa Y, et. al.
  • Journal Title: Annals of Nuclear Medicine (In press)
  • Peer Reviewed
• [Presentation] ラットにおけるプラナーポジトロンイメージング装置による11C-Phenytoinの薬物動態評価 (2007)
  • Author(s): 長谷川 雪憲、他
  • Organizer: 日本核医学会
  • Place of Presentation: 仙台市
  • Year and Date: 2007-11-04